Nutrients

14 pages, 583 KiB

Open AccessArticle

From Childhood Interpersonal Trauma to Binge Eating in Adults: Unraveling the Role of Personality and Maladaptive Regulation

by Lily Bellehumeur-Béchamp, Maxime Legendre and Catherine Bégin

Nutrients 2024, 16(24), 4427; https://doi.org/10.3390/nu16244427 - 23 Dec 2024

Viewed by 999

Abstract

Background/Objectives: Binge eating (BE) is associated with physical and psychological consequences, such as obesity and reduced quality of life. The relationship between binge eating and childhood experiences of interpersonal trauma has been explored, yet few studies focus on the processes that may [...] Read more.

Background/Objectives: Binge eating (BE) is associated with physical and psychological consequences, such as obesity and reduced quality of life. The relationship between binge eating and childhood experiences of interpersonal trauma has been explored, yet few studies focus on the processes that may explain this association. In this regard, some personality traits and maladaptive cognitive-emotional regulation may help explain this relationship, as they have been associated, respectively, with BE and childhood interpersonal trauma. The purpose of this study is to explore the complex processes that link childhood interpersonal trauma and BE in a French-Canadian clinical adult population with obesity (BMI ≥ 30 kg/m²). Methods: This cross-sectional study included 148 participants aged 21 to 72, predominantly women of White ethnic background with a university degree, who were seeking treatment for eating or weight-related issues. They completed self-report questionnaires assessing maltreatment and bullying, BE, maladaptive cognitive-emotional regulation, and personality. Two multiple mediation models were tested to examine the indirect effects of personality and maladaptive regulation in the relationship between bullying and BE, as well as between maltreatment and BE. Results: The results revealed a significant indirect relationship between maltreatment and binge eating (BE), with personality traits and maladaptive cognitive-emotional regulation partially explaining this association. No direct effect was found for bullying, but a significant total indirect effect indicated that personality traits and maladaptive cognitive-emotional regulation play a mediating role in the relationship between bullying and BE. Finaly, self-directedness was found as a unique and significant contributor in both mediation models. Conclusions: This study draws attention to the multiple contributing factors in the relationship between interpersonal trauma and BE in adults with obesity. Further research is needed to gain a deeper understanding of the role of personality and maladaptive cognitive-emotional regulation in this relationship by focusing on individuals’ experiences. Full article

(This article belongs to the Section Nutrition and Public Health)

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14 pages, 1182 KiB

Open AccessArticle

Time-Restricted Eating in Real-World Healthcare Settings: Utilisation and Short-Term Outcomes Evaluation

by Hilmi S. Rathomi, Judith Katzenellenbogen, Nahal Mavaddat, Kirsty Woods and Sandra C. Thompson

Nutrients 2024, 16(24), 4426; https://doi.org/10.3390/nu16244426 - 23 Dec 2024

Viewed by 902

Abstract

Background: Time-restricted eating (TRE) shows promise for managing weight and metabolic issues, yet its application in real-world healthcare settings remains underexplored. This study aims to assess the real-world utilisation and short-term outcomes of TRE in clinical practice. Methods: This observational study used a [...] Read more.

Background: Time-restricted eating (TRE) shows promise for managing weight and metabolic issues, yet its application in real-world healthcare settings remains underexplored. This study aims to assess the real-world utilisation and short-term outcomes of TRE in clinical practice. Methods: This observational study used a retrospective chart review of 271 adults who attended a metabolic specialist clinic between 2019 and 2023. Descriptive statistics and multivariable logistic regression were used to identify factors associated with TRE adoption, while paired sample t-tests evaluated changes in outcomes among those who received TRE advice. Results: Among the 271 patients, 76% were female, 90% Caucasian, and 94% overweight/obese. Of all patients, 47.2% received TRE advice, mainly using the 16:8 method, alongside additional dietary guidance for 60% of patients. Working status and baseline metabolic profiles were the only factors significantly associated with TRE adoption. Among those who followed TRE, 81% experienced modest but significant reductions in weight (−1.2 kg, p < 0.01), BMI (−0.4 kg/m², p < 0.01), and waist circumference (−3.7 cm, p < 0.01). Conclusions: This study highlights TRE as a feasible and practical dietary strategy for improving metabolic health in healthcare settings. However, further research and improved data capture are needed to explore long-term adherence, potential adverse effects, and the effectiveness of TRE across diverse patient populations. Full article

(This article belongs to the Section Clinical Nutrition)

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23 pages, 10675 KiB

Open AccessArticle

The Effects of Novel Co-Amorphous Naringenin and Fisetin Compounds on a Diet-Induced Obesity Murine Model

by Sarai Vásquez-Reyes, Miranda Bernal-Gámez, Jorge Domínguez-Chávez, Karina Mondragón-Vásquez, Mónica Sánchez-Tapia, Guillermo Ordaz, Omar Granados-Portillo, Diana Coutiño-Hernández, Paulina Barrera-Gómez, Nimbe Torres and Armando R. Tovar

Nutrients 2024, 16(24), 4425; https://doi.org/10.3390/nu16244425 - 23 Dec 2024

Viewed by 1190

Abstract

Background/Objective: In recent studies, it has been shown that dietary bioactive compounds can produce health benefits; however, it is not known whether an improvement in solubility can enhance their biological effects. Thus, the aim of this work was to study whether co-amorphous (CoA) [...] Read more.

Background/Objective: In recent studies, it has been shown that dietary bioactive compounds can produce health benefits; however, it is not known whether an improvement in solubility can enhance their biological effects. Thus, the aim of this work was to study whether co-amorphous (CoA) naringenin or fisetin with enhanced solubility modify glucose and lipid metabolism, thermogenic capacity and gut microbiota in mice fed a high-fat, high-sucrose (HFSD) diet. Methods: Mice were fed with an HFSD with or without CoA-naringenin or CoA-fisetin for 3 months. Body weight, food intake, body composition, glucose tolerance, hepatic lipid composition and gut microbiota were assessed. Results: CoA-naringenin demonstrated significant reductions in fat-mass gain, improved cholesterol metabolism, and enhanced glucose tolerance. Mice treated with CoA-naringenin gained 45% less fat mass and exhibited improved hepatic lipid profiles, with significant reductions seen in liver triglycerides and cholesterol. Additionally, both CoA-flavonoids increased oxygen consumption (VO₂), contributing to enhanced energy expenditure and improved metabolic flexibility. Thermogenic activation, indicated by increased UCP1 and PGC-1α levels, was observed with CoA-fisetin, supporting its role in fat oxidation and adipocyte size reduction. Further, both CoA-flavonoids modulated gut microbiota, restoring diversity and promoting beneficial bacteria, such as Akkermansia muciniphila, which has been linked to improved metabolic health. Conclusions: These findings suggest that co-amorphous naringenin or fisetin offers promising applications in improving solubility, metabolic health, and thermogenesis, highlighting the potential of both as therapeutic agents against obesity and related disorders. Full article

(This article belongs to the Section Nutrition and Obesity)

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20 pages, 2125 KiB

Open AccessReview

Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan

by Hye-Yeon Lee and Kyung-Jin Min

Nutrients 2024, 16(24), 4424; https://doi.org/10.3390/nu16244424 - 23 Dec 2024

Viewed by 954

Abstract

Dietary restriction (DR) has been reported to be a significant intervention that influences lipid metabolism and potentially modulates the aging process in a wide range of organisms. Lipid metabolism plays a pivotal role in the regulation of aging and longevity. In this review, [...] Read more.

Dietary restriction (DR) has been reported to be a significant intervention that influences lipid metabolism and potentially modulates the aging process in a wide range of organisms. Lipid metabolism plays a pivotal role in the regulation of aging and longevity. In this review, we summarize studies on the significant role of lipid metabolism in aging in relation to DR. As a potent intervention to slow down aging, DR has demonstrated promising effects on lipid metabolism, influencing the aging processes across various species. The current review focuses on the relationships among DR-related molecular signaling proteins such as the sirtuins, signaling pathways such as the target of rapamycin and the insulin/insulin-like growth factor (IGF)-1, lipid metabolism, and aging. Furthermore, the review presents research results on diet-associated changes in cell membrane lipids and alterations in lipid metabolism caused by commensal bacteria, highlighting the importance of lipid metabolism in aging. Overall, the review explores the interplay between diet, lipid metabolism, and aging, while presenting untapped areas for further understanding of the aging process. Full article

(This article belongs to the Special Issue Dietary Strategies for Prevention of Geriatric Diseases and Exploring the Mechanism of Aging)

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14 pages, 1864 KiB

Open AccessArticle

by Jieun Shin, Inhae Kang and Myoungsook Lee

Nutrients 2024, 16(24), 4423; https://doi.org/10.3390/nu16244423 - 23 Dec 2024

Viewed by 599

Abstract

This study investigated how the DNACJ6 gene variation related to RMR alteration affects risk factors of obese environments in children with obesity aged 8–9. Methods: Over a three-year follow-up period, 63.3% of original students participated. Changes in the variables (anthropometrics, blood biochemistry, and [...] Read more.

This study investigated how the DNACJ6 gene variation related to RMR alteration affects risk factors of obese environments in children with obesity aged 8–9. Methods: Over a three-year follow-up period, 63.3% of original students participated. Changes in the variables (anthropometrics, blood biochemistry, and dietary intakes) were analyzed and compared between those without obesity (non-OB) and with obesity (OB) classified at the study endpoint. Result: The average MAF of nine SNPs (D-1 to D-IX) was defined as 18.1%. The OB group showed greater increases in RMR, BMI, WC, and SBP, while the non-OB group had significantly greater increases in HDL and intakes of nutrients (e.g., total calories, vitamins B2, C, folate, A, retinol, iron, and zinc). Increased RMR, BMI, BW, and RMR/BW changes were observed with mutant allele of D-I SNP, which was also associated with a higher prevalence of obesity. Greater increases in animal fat intake, including saturated fatty acids and retinol, were noted in the minor alleles of D-VI, D-VII, D-VIII, and D-IX SNPs compared to those of the major alleles. The odds ratio for BMI risk was significantly higher in the mutant alleles of D-I (rs17127601), D-VII (rs1334880), and D-VIII (rs7354899) compared to the wild type, with increases of 2.59 times (CI; 1.068–6.274), 1.86 times (CI; 1.012–3.422), and 1.85 times (CI; 1.008–3.416), respectively. RMR was a mild risk factor in minors of the D-1, D-VII, and D-VIII; however, a higher RMR/BW ratio significantly correlated with decreased BMI risk, and this effect was found in only the major alleles of D-I, D-VII, and D-VIII SNPs, not in the minor alleles. High retinol intake appeared to reduce obesity risk in the minor alleles of the D-I, D-VII, and D-VIII SNPs, even though intake of animal fats and retinol remained higher among minors over the three years. Conclusions: These findings suggest that the RMR/BW ratio and dietary fat/retinol intake should be considered in DNACJ6-gene-based precision medicine approaches for pediatric obesity prevention, particularly for boys. Full article

(This article belongs to the Section Pediatric Nutrition)

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10 pages, 1156 KiB

Open AccessArticle

Efficiency of Skeletal Muscle Mass/Weight Measurement for Distinguishing Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Analysis Using InBody Bioimpedance Devices

by Miwa Tatsuta, Tsutomu Masaki, Shungo Kimura, Yudai Sato, Akemi Tomida, Ichiro Ishikawa, Yu Nakamura, Kei Takuma, Mai Nakahara, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Asahiro Morishita, Takashi Himoto, Shinjiro Miyazaki, Tsuyoshi Maeta, Yoshihiro Mori, Fumikazu Kohi and Hideki Kobara

Nutrients 2024, 16(24), 4422; https://doi.org/10.3390/nu16244422 - 23 Dec 2024

Viewed by 581

Abstract

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is diagnosed when hepatic steatosis is proven by imaging and one of the five cardiometabolic criteria is present. The relationship between MASLD and body composition components has recently received increased research attention. However, the five cardiometabolic [...] Read more.

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is diagnosed when hepatic steatosis is proven by imaging and one of the five cardiometabolic criteria is present. The relationship between MASLD and body composition components has recently received increased research attention. However, the five cardiometabolic criteria do not include components of body composition. This study aimed to identify significant body composition factors associated with MASLD in patients undergoing health checkups. Methods: This study included a cohort of 6599 examinees who participated in a health check-up conducted between 2022 and 2023, and their data were prospectively analyzed. The inclusion criteria were undergoing abdominal ultrasonography, alcohol consumption <30 g/day for males or <20 g/day for females, and one of the five cardiometabolic criteria. Results: Finally, 3864 examinees were enrolled. In total, 1133 (51.8%) males and 454 (27.1%) females had MASLD. Sarcopenia was present in only 0.62% of males and 0.66% of females with MASLD. The MASLD group had significantly lower skeletal muscle mass/weight (SMM/WT) values than the non-MASLD group. Multivariate analysis revealed that SMM/WT was independently associated with MASLD. Conclusions: SMM/WT was significantly associated with MASLD. Therefore, muscle mass assessment using SMM/WT may be a potential marker for diagnosing MASLD. Full article

(This article belongs to the Special Issue Relationship Between Diet and Lifestyle and Liver Health: From the Latest Perspective)

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18 pages, 753 KiB

Open AccessArticle

Short-Term Supplementation of Sauerkraut Induces Favorable Changes in the Gut Microbiota of Active Athletes: A Proof-of-Concept Study

by Andrija Karačić, Jadran Zonjić, Ena Stefanov, Katja Radolović, Antonio Starčević, Ira Renko, Željko Krznarić, Matija Ivančić, Zvonimir Šatalić and Ana-Marija Liberati Pršo

Nutrients 2024, 16(24), 4421; https://doi.org/10.3390/nu16244421 - 23 Dec 2024

Viewed by 1343

Abstract

Background: Since the gut microbiota is important for athlete health and performance, its optimization is increasingly gaining attention in sports nutrition, for example, with whole fermented foods. Sauerkraut is a traditional fermented food rich in pro-, pre-, and postbiotics, which has not yet [...] Read more.

Background: Since the gut microbiota is important for athlete health and performance, its optimization is increasingly gaining attention in sports nutrition, for example, with whole fermented foods. Sauerkraut is a traditional fermented food rich in pro-, pre-, and postbiotics, which has not yet been investigated in the field of sports nutrition. Methods: To determine whether sauerkraut could be used for gut microbiota optimization in sports nutrition, a proof-of-concept study was conducted. The microbiota composition of organic pasteurized sauerkraut was analyzed, and then healthy active athletes were provided with the same sauerkraut for 10 days as an intervention. The effects of sauerkraut on the athlete’s gut microbiota, laboratory parameters, and bowel function were assessed. Results: Significant changes in the gut microbiota composition were seen on taxonomic and functional levels, independent of baseline microbiota composition, even after short-term supplementation. Most notably, there was an increase in several health-promoting genera of the family Lachnospiraceae, as well as significant alterations in metabolic pathways regarding cell wall synthesis and the metabolism of nucleotide bases. An increase in the proportion of lymphocytes and a decrease in B12 vitamin levels was observed, as well as a risk of indigestion in certain athletes, which significantly resolved after seven days of supplementation in all athletes. It is unclear whether the observed effects are attributable to the sauerkraut’s own microbiome or its pre- and postbiotics since it is a whole food. Conclusions: Our study has demonstrated that the concept of whole fermented foods, such as sauerkraut, could potentially be feasible and effective in sports nutrition for gut microbiota optimization. Full article

(This article belongs to the Special Issue Nutrition–Microbiome Interaction in Healthy Metabolism)

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3 pages, 161 KiB

Open AccessEditorial

Editorial for the Special Issue: Geriatric Nursing Nutrition

by Edda Cava and Mauro Lombardo

Nutrients 2024, 16(24), 4420; https://doi.org/10.3390/nu16244420 - 23 Dec 2024

Viewed by 467

Abstract

Malnutrition, a significant risk factor for mortality and morbidity in the elderly, poses a huge threat in the geriatric population, showing a high prevalence, especially in people affected by chronic non-communicable age-related diseases [...] Full article

(This article belongs to the Special Issue Geriatric Nursing Nutrition)

13 pages, 2146 KiB

Open AccessArticle

Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer’s Disease Patients

by Serena Rustichelli, Cristina Lanni, Marta Zarà, Gianni Francesco Guidetti, Mauro Torti and Ilaria Canobbio

Nutrients 2024, 16(24), 4419; https://doi.org/10.3390/nu16244419 - 23 Dec 2024

Viewed by 712

Abstract

Background/Objectives: Amyloid peptides, whose accumulation in the brain as senile plaques is associated with the onset of Alzheimer’s disease, are also found in cerebral vessels and in circulation. In the bloodstream, amyloid peptides promote platelet adhesion, activation, oxidative stress, and thrombosis, contributing to [...] Read more.

Background/Objectives: Amyloid peptides, whose accumulation in the brain as senile plaques is associated with the onset of Alzheimer’s disease, are also found in cerebral vessels and in circulation. In the bloodstream, amyloid peptides promote platelet adhesion, activation, oxidative stress, and thrombosis, contributing to the cardiovascular complications observed in Alzheimer’s disease patients. Natural compounds, such as curcumin, are known to modulate platelet activation induced by the hemostatic stimuli thrombin and convulxin. In this study, we investigated the ability of curcumin to modulate platelet activation triggered by amyloid peptides, and we compared its effects with those displayed on platelet activation induced by physiological agonists. Methods: Commercial ultrapure curcumin was used, and platelet aggregation, granule secretion, phosphorylation of selected signaling proteins, and reactive oxygen species production were analyzed on isolated human platelets. Results: Our results demonstrate that curcumin effectively suppressed platelet aggregation induced by fibrillar amyloid peptides. This effect was associated with the reduction in intracellular signaling pathways involving PKC, PI3K, and MAPK. By contrast, platelet aggregation and activation induced by thrombin and convulxin were only partially reduced by preincubation with curcumin. Moreover, curcumin completely suppressed granule secretion only when platelets were stimulated with hemostatic agonists, but it had no effects upon stimulation with amyloid peptides. Additionally, curcumin reduced the production of reactive oxygen species induced by amyloid peptides with a stronger efficiency compared to platelets stimulated with thrombin. Conclusions: These results indicate that curcumin displays selective and potent inhibitory activity on platelet responses to pathological stimuli, such as fibrillar amyloid peptides. Full article

(This article belongs to the Section Nutrition and Metabolism)

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27 pages, 421 KiB

Open AccessReview

A Narrative Review on the Neurocognitive Profiles in Eating Disorders and Higher Weight Individuals: Insights for Targeted Interventions

by Isabel Krug, An Binh Dang, Evonne Lu, Wenn Lynn Ooi, Jade Portingale and Stephanie Miles

Nutrients 2024, 16(24), 4418; https://doi.org/10.3390/nu16244418 - 23 Dec 2024

Viewed by 701

Abstract

Background/Objectives: Recent research has increasingly explored the cognitive processes underlying eating disorders (EDs), including anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), other specified feeding or eating disorders (OSFEDs), and individuals with higher weight (HW). This critical narrative review focuses [...] Read more.

Background/Objectives: Recent research has increasingly explored the cognitive processes underlying eating disorders (EDs), including anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), other specified feeding or eating disorders (OSFEDs), and individuals with higher weight (HW). This critical narrative review focuses on neurocognitive findings derived from mainly experimental tasks to provide a detailed understanding of cognitive functioning across these groups. Where experimental data are lacking, we draw on self-report measures and neuroimaging findings to offer supplementary insights. Method: A search of major databases that prioritized meta-analyses and recent publications (last 10 years) was conducted. Using comprehensive search terms related to EDs, HW, and neurocognition, eligible studies focused on human neurocognitive outcomes (e.g., cognitive flexibility, attentional bias, etc.) published in English were selected. Results: We found that some neurocognitive characteristics, such as cognitive rigidity, impulsivity, emotion processing difficulties, and dysregulated reward processing, appear transdiagnostic, spanning multiple ED subtypes and HW populations. We also revealed neurocognitive features specific to ED subtypes and HW. For instance, individuals with AN demonstrate an enhanced focus on detail, and BN and BED are characterized by a pronounced attentional bias toward food-related stimuli. In individuals with HW, cognitive processes underpin behaviours associated with overeating and weight gain. Conclusions: These findings highlight the critical importance of understanding both the unique and shared neurocognitive patterns across ED subtypes and HW populations. By identifying transdiagnostic factors, such as cognitive rigidity and reward processing, alongside ED subtype/HW-specific vulnerabilities, researchers and clinicians can develop more nuanced, evidence-based interventions that address the core mechanisms driving disordered eating behaviours. Full article

(This article belongs to the Special Issue Nutrition and Dietary Patterns: Effects on Brain Function)

14 pages, 2192 KiB

Open AccessArticle

Heat-Killed Lactobacillus delbrueckii subsp. lactis 557 Extracts Protect Chondrocytes from Osteoarthritis Damage by Reducing Inflammation: An In Vitro Study

by Yu-Chen Hu, Tzu-Ching Huang, Bau-Shan Hsieh, Li-Wen Huang, Jin-Seng Lin, Han-Yin Hsu, Chia-Chia Lee and Kee-Lung Chang

Nutrients 2024, 16(24), 4417; https://doi.org/10.3390/nu16244417 - 23 Dec 2024

Viewed by 1074

Abstract

Background: Osteoarthritis (OA) is a chronic condition characterized by joint pain and disability, driven by excessive oxidative stress and inflammatory cytokine production in chondrocytes, resulting in cell death and cartilage matrix breakdown. Our previous study showed that in monosodium iodoacetate (MIA)-induced OA rats, [...] Read more.

Background: Osteoarthritis (OA) is a chronic condition characterized by joint pain and disability, driven by excessive oxidative stress and inflammatory cytokine production in chondrocytes, resulting in cell death and cartilage matrix breakdown. Our previous study showed that in monosodium iodoacetate (MIA)-induced OA rats, oral administration of heat-killed Lactobacillus delbrueckii subsp. lactis 557 (LDL557) could significantly decrease OA progression. Methods: Accordingly, we designed an in vitro cell culture study aimed at investigating the effects of heat-killed LDL557 extracts on chondrocytes using SW1353 cells (a human chondrosarcoma cell line) challenged with 5 μM MIA to mimic OA conditions. Results: The results showed that the 10 μg/mL LDL557 extracts protected SW1353 cells from MIA-induced death and reduced extracellular matrix (ECM) loss, as evaluated by toluidine blue O staining and extracellular matrix component synthesis with RT-qPCR measurement. This was achieved by decreasing the expression of MIA-induced pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, while slightly increasing the MIA-suppressed expression of the anti-inflammatory cytokine IL-10, which were evidenced by RT-qPCR analysis. Moreover, the RT-qPCR evaluation also indicated that the LDL557 extracts slightly reduced the expression of COX-2 compared with the control, while it did not reduce the MIA-increased expression of microsomal prostaglandin E synthase-1 (mPGES-1). In addition, the LDL557 extracts influenced neither the matrix-degrading protease expressions measured via RT-qPCR nor the oxidative stress measured via fluorescence flow cytometry in the cells with or without the MIA challenge. Conclusions: This study demonstrates that LDL557 extracts may protect chondrocytes from OA damage by reducing inflammation-related factors and thus mitigating cartilage matrix loss, suggesting LDL557 extracts are attractive alternatives for OA applications. Full article

(This article belongs to the Special Issue Functional Foods and Sustainable Health (2nd Edition))

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3 pages, 172 KiB

Open AccessEditorial

Update on Fatty Acids and the Brain

by Andrew J. Sinclair

Nutrients 2024, 16(24), 4416; https://doi.org/10.3390/nu16244416 - 23 Dec 2024

Viewed by 618

Abstract

The brain is a lipid-rich organ, mainly due to the very high lipid content of myelin, but in addition to this, all the neuronal cell membranes, of which there are over 80 billion in the human brain [...] Full article

(This article belongs to the Special Issue Update on Fatty Acids and the Brain)

17 pages, 4931 KiB

Open AccessArticle

Caryophylli Cortex Suppress PD-L1 Expression in Cancer Cells and Potentiates Anti-Tumor Immunity in a Humanized PD-1/PD-L1 Knock-In MC-38 Colon Cancer Mouse Model

by Aeyung Kim, Eun-Ji Lee, Jung Ho Han and Hwan-Suck Chung

Nutrients 2024, 16(24), 4415; https://doi.org/10.3390/nu16244415 - 23 Dec 2024

Viewed by 609

Abstract

Background/Objectives: Immune checkpoints are essential for regulating excessive autoimmune responses and maintaining immune homeostasis. However, in the tumor microenvironment, these checkpoints can lead to cytotoxic T cell exhaustion, allowing cancer cells to evade immune surveillance and promote tumor progression. The expression of programmed [...] Read more.

Background/Objectives: Immune checkpoints are essential for regulating excessive autoimmune responses and maintaining immune homeostasis. However, in the tumor microenvironment, these checkpoints can lead to cytotoxic T cell exhaustion, allowing cancer cells to evade immune surveillance and promote tumor progression. The expression of programmed death-ligand 1 (PD-L1) in cancer cells is associated with poor prognoses, reduced survival rates, and lower responses to therapies. Consequently, downregulating PD-L1 expression has become a key strategy in developing immune checkpoint inhibitors (ICIs). Caryophylli cortex (CC), derived from the bark of the clove tree Syzygium aromaticum, possesses antioxidant and cytotoxic properties against cancer cells, yet its potential as an ICI remains unclear. Methods: In this study, we aimed to investigate whether CC extract modulates PD-L1 expression in cancer cells and activates T cell immunity through a co-culture system of cancer cells and T cells, as well as in hPD-L1/MC-38 tumor-bearing animal models. Results: Our findings indicate that CC extract significantly downregulated both constitutive and inducible PD-L1 expression at non-toxic concentrations for cancer cells while simultaneously enhancing cancer cell mortality and T cell activity in the co-culture system. Furthermore, the administration of CC extract to hPD-L1/MC-38 tumor-bearing mice resulted in a greater than 70% reduction in tumor growth and increased infiltration of CD8+ T cells within the tumor microenvironment. Principal component analysis identified bergenin, chlorogenic acid, and ellagic acid as active ICIs. Conclusions: These findings suggest that CC extract exerts a potent antitumor effect as an immune checkpoint blocker by inhibiting PD-L1 expression in cancer cells and disrupting the PD-1/PD-L1 interaction. Full article

(This article belongs to the Special Issue Therapeutic Potential and Mechanisms of Phytochemical Extracts in Cancer Treatment)

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3 pages, 154 KiB

Open AccessEditorial

The Critical Role of Lipid Metabolism in Health and Diseases

by Yucheng Zhu, Fangyan Wan, Jie Liu, Zhihao Jia and Tongxing Song

Nutrients 2024, 16(24), 4414; https://doi.org/10.3390/nu16244414 - 23 Dec 2024

Viewed by 844

Abstract

Lipids make up 10–20% of the human body and serve as crucial energy storage substances as well as essential components of cell membranes [...] Full article

(This article belongs to the Special Issue Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and Diseases)

19 pages, 1017 KiB

Open AccessSystematic Review

A Systematic Review and Meta-Analysis of Type 2 Diabetes Prevention Through Lifestyle Interventions in Women with a History of Gestational Diabetes—A Summary of Participant and Intervention Characteristics

by Gebresilasea Gendisha Ukke, Jacqueline A. Boyle, Ahmed Reja, Wai Kit Lee, Mingling Chen, Michelle Shi Min Ko, Chelsea Alycia, Jane Kwon and Siew Lim

Nutrients 2024, 16(24), 4413; https://doi.org/10.3390/nu16244413 - 23 Dec 2024

Viewed by 849

Abstract

Objectives: We aimed to review the effect of lifestyle interventions in women with a history of gestational diabetes mellitus (GDM) based on the participants and intervention characteristics. Methods: We systematically searched seven databases for RCTs of lifestyle interventions published up to [...] Read more.

Objectives: We aimed to review the effect of lifestyle interventions in women with a history of gestational diabetes mellitus (GDM) based on the participants and intervention characteristics. Methods: We systematically searched seven databases for RCTs of lifestyle interventions published up to 24 July 2024. We included 30 studies that reported the incidence of type 2 diabetes mellitus (T2DM) or body weight. A random effects model was used to calculate the relative risk and mean difference with a 95% confidence interval. Subgroup analyses were conducted for participants’ characteristics (age, body mass index (BMI)) and intervention characteristics according to the Template for Intervention Description and Replication (TIDieR). Results: A greater T2DM risk reduction was seen in trials that started within one year postpartum, in participants with a mean baseline BMI of 30 kg/m² or more, or based on behavioral change theory. For body weight reduction, studies on participants with a mean baseline BMI of 25 kg/m² or more or ones that included electronic/mobile delivery (text message, web, phone call) were more effective. Conclusions: Diabetes prevention trials in women with a history of GDM are more effective when commencing within one year postpartum, underpinned by behavior change theory, and in participants with overweight or obesity. Full article

(This article belongs to the Special Issue Dietary and Exercise Interventions to Target Obesity and Chronic Diseases)

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19 pages, 3847 KiB

Open AccessArticle

The Effect of Ingesting Alginate-Encapsulated Carbohydrates and Branched-Chain Amino Acids During Exercise on Performance, Gastrointestinal Symptoms, and Dental Health in Athletes

by Lotte L. K. Nielsen, Max Norman Tandrup Lambert, Jørgen Jensen and Per Bendix Jeppesen

Nutrients 2024, 16(24), 4412; https://doi.org/10.3390/nu16244412 - 23 Dec 2024

Viewed by 878

Abstract

Background: This study aimed to compare the effects of a carbohydrate (CHO) hydrogel with (ALG-CP) or without (ALG-C) branched-chain amino acids, and a CHO-only non-hydrogel (CON), on cycling performance. The hydrogels, encapsulated in an alginate matrix, are designed to control CHO release, potentially [...] Read more.

Background: This study aimed to compare the effects of a carbohydrate (CHO) hydrogel with (ALG-CP) or without (ALG-C) branched-chain amino acids, and a CHO-only non-hydrogel (CON), on cycling performance. The hydrogels, encapsulated in an alginate matrix, are designed to control CHO release, potentially optimising absorption, increasing substrate utilisation, and reducing gastrointestinal distress as well as carious lesions. Methods: In a randomised, double-blinded, crossover trial, 10 trained male cyclists/triathletes completed three experimental days separated by ~6 days. During the experimental days, participants completed a standardised 2 h cycling bout (EX1), followed by a time-to-exhaustion (TTE) performance test at W_75%. Supplements were ingested during EX1. Results: Participants cycled ~8.8 (29.6%) and ~5.4 (29.1%) minutes longer during TTE with ALG-CP compared to ALG-C and CON, respectively. TTE was 65.28 ± 2.8 min with ALG-CP, 56.46 ± 10.92 min with ALG-C, and 59.89 ± 11.89 min with CON. Heart rate (HR) was lower during EX1 with ALG-CP (p = 0.03), and insulin levels increased more significantly during the first 45 min with ALG-CP. Plasma glucose and glucagon levels remained consistent across supplements, although glucagon was higher with ALG-CP before TTE. Post-exercise myoglobin levels were lower with ALG-CP compared to ALG-C (p = 0.02), indicating reduced muscle damage. Conclusions: While ALG-CP improved performance duration compared to ALG-C and CON, the difference did not reach statistical significance. Additionally, there was a lower HR during the cycling session, alongside a significantly lower level of myoglobin with ALG-CP. These findings suggest that ALG-CP may offer advantages in cycling performance and recovery. Full article

(This article belongs to the Special Issue Nutrition and Supplements for Athletic Training and Racing)

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12 pages, 301 KiB

Open AccessReview

Importance of Fecal Microbiota Transplantation and Molecular Regulation as Therapeutic Strategies in Inflammatory Bowel Diseases

by Olga Brusnic, Adrian Boicean, Sorin-Radu Fleacă, Blanca Grama, Florin Sofonea, Corina Roman-Filip, Iulian Roman-Filip, Adelaida Solomon, Sabrina Bîrsan, Horatiu Dura, Corina Porr, Cristian Adrian and Danusia Maria Onisor

Nutrients 2024, 16(24), 4411; https://doi.org/10.3390/nu16244411 - 23 Dec 2024

Viewed by 829

Abstract

Noncoding RNAs, particularly microRNAs (miRNAs) and small interfering RNAs (siRNAs), have emerged as key players in the pathogenesis and therapeutic strategies for inflammatory bowel disease (IBD). MiRNAs, small endogenous RNA molecules that silence target mRNAs to regulate gene expression, are closely linked to [...] Read more.

Noncoding RNAs, particularly microRNAs (miRNAs) and small interfering RNAs (siRNAs), have emerged as key players in the pathogenesis and therapeutic strategies for inflammatory bowel disease (IBD). MiRNAs, small endogenous RNA molecules that silence target mRNAs to regulate gene expression, are closely linked to immune responses and inflammatory pathways in IBD. Notably, miR-21, miR-146a, and miR-155 are consistently upregulated in IBD, influencing immune cell modulation, cytokine production, and the intestinal epithelial barrier. These miRNAs serve as biomarkers for disease progression and severity, as well as therapeutic targets for controlling inflammation. This comprehensive review highlights the intricate interplay between the gut microbiota, fecal microbiota transplantation (FMT), and miRNA regulation. It concludes that microbiota and FMT influence miRNA activity, presenting a promising avenue for personalized IBD treatment. Full article

(This article belongs to the Special Issue Diet–Microbiome Interaction in Gastrointestinal Disorders)

14 pages, 695 KiB

Open AccessArticle

Adipokines and Gamma-Glutamyl Transferase as Biomarkers of Metabolic Syndrome Risk in Mexican School-Aged Children

by Elizabeth Solís-Pérez, Ana Marina Mar-Buruato, Alexandra Tijerina-Sáenz, Maria Alejandra Sánchez-Peña, Blanca Edelia González-Martínez, Fernando Javier Lavalle-González, Jesús Zacarías Villarreal-Pérez, Gerardo Sánchez-Solís and Manuel López-Cabanillas Lomelí

Nutrients 2024, 16(24), 4410; https://doi.org/10.3390/nu16244410 - 23 Dec 2024

Viewed by 624

Abstract

Background/Objectives: The prevalence of metabolic syndrome in children has been increasing, raising concerns about early detection and clinical management. Adipokines, which are secreted by adipose tissue, play a critical role in metabolic regulation and inflammation, while gamma-glutamyl transferase (GGT), as a liver [...] Read more.

Background/Objectives: The prevalence of metabolic syndrome in children has been increasing, raising concerns about early detection and clinical management. Adipokines, which are secreted by adipose tissue, play a critical role in metabolic regulation and inflammation, while gamma-glutamyl transferase (GGT), as a liver enzyme, is linked to oxidative stress and metabolic disorders. The objective was to examine the association of circulating adipokines and GGT with metabolic syndrome risk in school-aged children from Northeast Mexico. Methods: A total of 140 children from 6 to 12 years of age in the state of Nuevo León, Mexico, participated in this study. Obesity was classified according to the BMI z-score by the World Health Organization (WHO, 2007), and metabolic syndrome was classified according to the International Diabetes Federation (IDF, 2007). Serum levels of leptin, adiponectin, TNF-α, IL-6, and GGT were measured. Statistical analysis was performed using the Student’s t-test, simple linear regression analysis, and receiver operating characteristic (ROC) curve analysis. Results: Among the 140 participants, 60 children (43%) were classified as obese, and of those children with obesity, 55% were diagnosed with metabolic syndrome. Leptin was significantly associated with waist circumference (WC), systolic blood pressure (SBP), serum glucose, triglycerides, and HDL cholesterol (HDL-c). Adiponectin also showed significant associations with WC, SBP, serum triglycerides, and HDL-c. GGT was significantly correlated with WC and HDL-c, while IL-6 and TNF-α did not indicate significance. Associations were observed among leptin, adiponectin, and GGT, highlighting their combined role as potential markers for metabolic syndrome in children. The ROC curve analysis and Youden’s index provided cut-off points for these biomarkers: leptin: 8.3665 ng/mL, adiponectin: 9.87 µg/mL, GGT: 17.8 U/L, IL-6 2.77 pg/mL, and TNF-α: 6.68 pg/mL; Conclusions: These findings emphasize the utility of leptin, adiponectin, and GGT as early biomarkers for identifying children with obesity who are at risk of developing metabolic syndrome. Full article

(This article belongs to the Section Pediatric Nutrition)

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23 pages, 10531 KiB

Open AccessArticle

Investigation into the Potential Mechanism of Radix Paeoniae Rubra Against Ischemic Stroke Based on Network Pharmacology

by Tingyu Wen, Guang Xin, Qilong Zhou, Tao Wang, Xiuxian Yu, Yanceng Li, Shiyi Li, Ying Zhang, Kun Zhang, Ting Liu, Beiwei Zhu and Wen Huang

Nutrients 2024, 16(24), 4409; https://doi.org/10.3390/nu16244409 - 23 Dec 2024

Viewed by 679

Abstract

Background: Radix Paeoniae Rubra (RPR), an edible and medicinal Traditional Chinese Medicine (TCM), is extensively employed in therapeutic interventions of cardiovascular and cerebrovascular diseases. However, the curative effect of RPR on ischemic stroke remains ambiguous. This work integrated network pharmacology, molecular docking, and [...] Read more.

Background: Radix Paeoniae Rubra (RPR), an edible and medicinal Traditional Chinese Medicine (TCM), is extensively employed in therapeutic interventions of cardiovascular and cerebrovascular diseases. However, the curative effect of RPR on ischemic stroke remains ambiguous. This work integrated network pharmacology, molecular docking, and experimental validation to explore the mechanisms of RPR in treating ischemic stroke. Methods: In this study, we preliminarily elucidated the therapeutic effect and mechanism of RPR on ischemic stroke through network pharmacology, molecular docking analysis, and experimental verification. Results: The results indicated that RPR improved the neurological deficit scores, decreased the size of infarcts, and reduced brain edema symptoms in the tMCAO mice model. Furthermore, through network pharmacology and molecular docking, four core targets (MAPK3, TNF-α, MAPK14, and JNK) closely related to RPR’s treatment of ischemic stroke were identified, exhibiting strong affinity with two key active components of RPR: albiflorin (AF) and β-sitosterol (BSS). The Western blot showed the potential mechanism of RPR treatment for ischemic stroke by regulating the MAPK signaling pathway. Moreover, RPR and its main active ingredients exhibited a significant inhibitory effect on platelets. Conclusion: In conclusion, this study revealed that RPR alleviates ischemic injury by activating the MAPK signaling pathway, and its protective effect may partly stem from inhibiting platelet activation. This work may provide a scientific basis for the development and utilization of RPR as a natural edible material to prevent ischemic stroke and anti-platelet therapy. Full article

(This article belongs to the Special Issue Medicinal Plants and Natural Products for Human Health)

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10 pages, 215 KiB

Open AccessArticle

Evaluating the Impact of a Novel Program to Address Acute Food Insecurity Among Cancer Patients

by Elliott M. Sina, Michael Rowe, Gina Mancuso, Gregory Garber, W. Kevin Kelly and Amy E. Leader

Nutrients 2024, 16(24), 4408; https://doi.org/10.3390/nu16244408 - 23 Dec 2024

Viewed by 548

Abstract

Introduction: Acute food insecurity (FI) significantly impacts cancer patients’ health, exacerbating physical and psychological burdens. While current interventions address chronic FI, acute cases remain undermanaged. Legacy of Hope, a Philadelphia-based non-profit, addresses this gap through its Emergency Patient Support Network (EPSN), offering free [...] Read more.

Introduction: Acute food insecurity (FI) significantly impacts cancer patients’ health, exacerbating physical and psychological burdens. While current interventions address chronic FI, acute cases remain undermanaged. Legacy of Hope, a Philadelphia-based non-profit, addresses this gap through its Emergency Patient Support Network (EPSN), offering free bi-weekly groceries to patients facing acute FI. Materials and Methods: The pilot study evaluated EPSN’s impact utilizing the Legacy of Hope Acute Food Insecurity (LOHAFI) survey, which was performed at baseline and two weeks post-intervention. The survey combines the Functional Assessment of Cancer Therapy—General (FACT-G7) and questions on food and financial security. Mean scores and frequencies were calculated. Results: Fifty patients (n = 50) completed the LOHAFI survey. The mean age was 55.1 years; 70% were female; 33 (66%) identified as Black. Two weeks after receiving groceries, patients reported a decrease in nausea (pre: 1.34; post: 1.18) and anxiety related to their cancer (pre: 2.49; post: 2.41) and an increase in the availability (pre: 1.70; post: 1.84) and consumption (pre: 2.26; post: 2.30) of healthy food. However, patient overall quality of life did not improve (pre: 13.14; post: 12.76). Conclusions: Legacy of Hope’s EPSN shows potential in alleviating acute FI among cancer patients, although larger studies are needed to fully assess its impact. Full article

(This article belongs to the Section Nutrition and Public Health)

33 pages, 5885 KiB

Open AccessArticle

Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management

by Mats I. Nilsson, Donald Xhuti, Nicoletta Maria de Maat, Bart P. Hettinga and Mark A. Tarnopolsky

Nutrients 2024, 16(24), 4407; https://doi.org/10.3390/nu16244407 - 23 Dec 2024

Viewed by 1947

Abstract

Background: Anabolic resistance accelerates muscle loss in aging and obesity, thus predisposing to sarcopenic obesity. Methods: In this retrospective analysis of a randomized clinical trial, we examined baseline predictors of the adaptive response to three months of home-based resistance exercise, daily physical activity, [...] Read more.

Background: Anabolic resistance accelerates muscle loss in aging and obesity, thus predisposing to sarcopenic obesity. Methods: In this retrospective analysis of a randomized clinical trial, we examined baseline predictors of the adaptive response to three months of home-based resistance exercise, daily physical activity, and protein-based, multi-ingredient supplementation (MIS) in a cohort of free-living, older males (n = 32). Results: Multiple linear regression analyses revealed that obesity and a Global Risk Index for metabolic syndrome (MetS) were the strongest predictors of Δ% gains in lean mass (TLM and ASM), LM/body fat ratios (TLM/%BF, ASM/FM, and ASM/%BF), and allometric LM (ASMI, TLM/BW, TLM/BMI, ASM/BW), with moderately strong, negative correlations to the adaptive response to polytherapy r = −0.36 to −0.68 (p < 0.05). Kidney function, PA level, and chronological age were only weakly associated with treatment outcomes (p > 0.05). Next, we performed a subgroup analysis in overweight/obese participants with at least one other MetS risk factor and examined their adaptive response to polytherapy with two types of protein-based MIS (PLA; collagen peptides and safflower oil, n = 8, M5; whey/casein, creatine, calcium, vitamin D₃, and fish oil, n = 12). The M5 group showed greater improvements in LM (ASM; +2% vs. −0.8%), LM/body fat ratios (ASM/FM; +3.8% vs. −5.1%), allometric LM (ASM/BMI; +1.2% vs. −2.5%), strength (leg press; +17% vs. −1.4%), and performance (4-Step-Stair-Climb time; −10.5% vs. +1.1%) vs. the PLA group (p < 0.05). Bone turnover markers, indicative of bone accretion, were increased pre-to-post intervention in the M5 group only (P1NP; p = 0.036, P1NP/CTX ratio; p = 0.088). The overall anabolic response, as indicated by ranking low-to-high responders for Δ% LM (p = 0.0079), strength (p = 0.097), and performance (p = 0.19), was therefore significantly higher in the M5 vs. PLA group (p = 0.013). Conclusions: Our findings confirm that obesity/MetS is a key driver of anabolic resistance in old age and that a high-quality, whey/casein-based MIS is more effective than a collagen-based alternative for maintaining musculoskeletal health in individuals at risk for sarcopenic obesity, even when total daily protein intake exceeds current treatment guidelines. Full article

(This article belongs to the Special Issue Diet and Nutrition Approaches in Obesity Treatment)

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12 pages, 1563 KiB

Open AccessArticle

Efficacy of Oral Probiotic Supplementation in Preventing Vulvovaginal Infections During Pregnancy: A Randomized and Placebo-Controlled Clinical Trial

by Enav Yefet, Abeer Suleiman, Raul Colodner, Shlomo Battino, Malak Wattad, Olga Kuzmin and Zohar Nachum

Nutrients 2024, 16(24), 4406; https://doi.org/10.3390/nu16244406 - 22 Dec 2024

Viewed by 980

Abstract

Background/Objective: This study aimed to investigate the efficacy of oral probiotic supplementation in preventing vulvovaginal infections (VVIs) in pregnant women, specifically focusing on abnormal vaginal flora (AVF), bacterial vaginosis (BV), and vulvovaginal candidiasis (VVC). Methods: A multicenter-prospective-randomized, double-blind, placebo-controlled trial was conducted during [...] Read more.

Background/Objective: This study aimed to investigate the efficacy of oral probiotic supplementation in preventing vulvovaginal infections (VVIs) in pregnant women, specifically focusing on abnormal vaginal flora (AVF), bacterial vaginosis (BV), and vulvovaginal candidiasis (VVC). Methods: A multicenter-prospective-randomized, double-blind, placebo-controlled trial was conducted during 2016–2019. Women with normal vaginal flora (Nugent score < 4 and no candida) were divided into a research group, receiving 2 capsules/day of oral probiotic formula containing Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus, Lacticaseibacillus paracasei, Lacticaseibacillus rhamnosus, and Streptococcus thermophilus, or a control group, receiving a placebo until delivery. Once a month and following complaints, a vaginal smear was taken to assess vaginal flora. Vaginal colonization with the specific lactobacilli from the probiotic capsules was detected using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The primary outcome was the rate of women who developed VVI. Results: Forty-nine and fifty-one women were analyzed in the probiotic and placebo cohorts, respectively. There was no difference in the rate of VVI between probiotic and placebo groups (14 (29%) versus 14 (27%), respectively; p = 0.80). No woman had vaginal colonization with lactobacilli from the probiotic capsule. Conclusions: The tested oral probiotic product did not reduce the rate of VVI in pregnant women with normal vaginal flora. Full article

(This article belongs to the Section Prebiotics and Probiotics)

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21 pages, 1130 KiB

Open AccessReview

Gut Microbiome Modulation of Glutamate Dynamics: Implications for Brain Health and Neurotoxicity

by Benjamin F. Gruenbaum, Kiran S. Merchant, Alexander Zlotnik and Matthew Boyko

Nutrients 2024, 16(24), 4405; https://doi.org/10.3390/nu16244405 - 22 Dec 2024

Viewed by 1255

Abstract

The gut–brain axis plays an integral role in maintaining overall health, with growing evidence suggesting its impact on the development of various neuropsychiatric disorders, including depression. This review explores the complex relationship between gut microbiota and glutamate (Glu) regulation, highlighting its effect on [...] Read more.

The gut–brain axis plays an integral role in maintaining overall health, with growing evidence suggesting its impact on the development of various neuropsychiatric disorders, including depression. This review explores the complex relationship between gut microbiota and glutamate (Glu) regulation, highlighting its effect on brain health, particularly in the context of depression following certain neurological insults. We discuss how microbial populations can either facilitate or limit Glu uptake, influencing its bioavailability and predisposing to neuroinflammation and neurotoxicity. Additionally, we examine the role of gut metabolites and their influence on the blood–brain barrier and neurotransmitter systems involved in mood regulation. The therapeutic potential of microbiome-targeted interventions, such as fecal microbiota transplantation, is also highlighted. While much research has explored the role of Glu in major depressive disorders and other neurological diseases, the contribution of gut microbiota in post-neurological depression remains underexplored. Future research should focus on explaining the mechanisms linking the gut microbiota to neuropsychiatric outcomes, particularly in conditions such as post-stroke depression, post-traumatic brain-injury depression, and epilepsy-associated depression. Systematic reviews and human clinical studies are needed to establish causal relationships and assess the efficacy of microbiome-targeted therapies in improving the neuropsychiatric sequalae after neurological insults. Full article

(This article belongs to the Special Issue Diet and Microbiota–Gut–Brain Axis: A Novel Nutritional Therapy)

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23 pages, 2016 KiB

Open AccessArticle

The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders

by Ioannis Alexandros Charitos, Angelo Michele Inchingolo, Laura Ferrante, Francesco Inchingolo, Alessio Danilo Inchingolo, Francesca Castellaneta, Antonella Cotoia, Andrea Palermo, Salvatore Scacco and Gianna Dipalma

Nutrients 2024, 16(24), 4404; https://doi.org/10.3390/nu16244404 - 22 Dec 2024

Viewed by 1518

Abstract

Aim: This article aims to explore the role of the human gut microbiota (GM) in the pathogenesis of neurological, psychiatric, and neurodevelopmental disorders, highlighting its influence on health and disease, and investigating potential therapeutic strategies targeting GM modulation. Materials and Methods: A comprehensive [...] Read more.

Aim: This article aims to explore the role of the human gut microbiota (GM) in the pathogenesis of neurological, psychiatric, and neurodevelopmental disorders, highlighting its influence on health and disease, and investigating potential therapeutic strategies targeting GM modulation. Materials and Methods: A comprehensive analysis of the gut microbiota’s composition and its interaction with the human body, particularly, its role in neurological and psychiatric conditions, is provided. The review discusses factors influencing GM composition, including birth mode, breastfeeding, diet, medications, and geography. Additionally, it examines the GM’s functions, such as nutrient absorption, immune regulation, and pathogen defense, alongside its interactions with the nervous system through the gut–brain axis, neurotransmitters, and short-chain fatty acids (SCFAs). Results: Alterations in the GM are linked to various disorders, including Parkinson’s disease, multiple sclerosis, depression, schizophrenia, ADHD, and autism. The GM influences cognitive functions, stress responses, and mood regulation. Antibiotic use disrupts GM diversity, increasing the risk of metabolic disorders, obesity, and allergic diseases. Emerging therapies such as probiotics, prebiotics, and microbiota transplantation show promise in modulating the GM and alleviating symptoms of neurological and psychiatric conditions. Conclusions. The modulation of the GM represents a promising approach for personalized treatment strategies. Further research is needed to better understand the underlying mechanisms and to develop targeted therapies aimed at restoring GM balance for improved clinical outcomes. Full article

(This article belongs to the Special Issue Implications of Diet and the Gut Microbiome in Neuroinflammation)

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14 pages, 622 KiB

Open AccessArticle

Validity of a Short Food Frequency Questionnaire for Toddlers of NELA Birth Cohort Study

by Sandra Gonzalez-Palacios, Carolina Ojeda-Belokon, Alejandro Oncina-Canovas, Laura-María Compañ-Gabucio, María-Teresa Pastor-Fajardo, Adrian Pérez, Antonio Gázquez, Elvira Larqué, Eva Morales, Jesús Vioque and on behalf of the NELA Study Group

Nutrients 2024, 16(24), 4403; https://doi.org/10.3390/nu16244403 - 22 Dec 2024

Viewed by 699

Abstract

Background/Objectives: Our aim was to evaluate the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) for the assessment of usual nutrient and food intakes in children of 18 months old. Methods: We included 103 toddlers aged 18 months from the Nutrition [...] Read more.

Background/Objectives: Our aim was to evaluate the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) for the assessment of usual nutrient and food intakes in children of 18 months old. Methods: We included 103 toddlers aged 18 months from the Nutrition in Early Life and Asthma (NELA) birth cohort study. A 47-item FFQ was administered twice to parents with a 3-month interval. During that period, we also performed three non-consecutive 24 h dietary recalls (24hDRs) and oral mucosa samples for determining the fatty acid profile (glycerophospholipids). We estimated correlation coefficients of reproducibility for nutrient and food group intakes by comparing both FFQs and validity coefficients by comparing nutrient intakes between the second FFQ and the average of the three 24hDRs. We also explored biochemical validity by comparing the intake of fish from the FFQ with the percentage of fatty acids in oral mucosa cells. Results: The average of correlation coefficients for FFQ reproducibility was r = 0.48 for energy-adjusted nutrient intakes (ranging from r = 0.28 for Na to r = 0.62 for Mg and Zn) and r = 0.35 for the intake of energy-adjusted food groups. The average correlation coefficient for FFQ validity on nutrient intakes was r = 0.48, ranging from r = 0.16 for α-carotene to r = 0.75 for vitamin E. We also found a positive correlation between total omega-3 fatty acids and docosahexaenoic acid percentages in oral mucosa cells and the intake of total and white fish, r = 0.31 and r = 0.34, respectively. Conclusions: This study shows that our short FFQ demonstrated moderate reproducibility (mean r = 0.48) and validity (mean r = 0.48) for dietary assessment of most nutrients and foods in 18-month-old children in Spain. This FFQ provides an efficient and minimally invasive method for evaluating toddler dietary intake, particularly in Mediterranean contexts. Full article

(This article belongs to the Section Nutritional Epidemiology)

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15 pages, 934 KiB

Open AccessArticle

Factors Associated with the Prolonged Use of Donor Human Milk at the Da Nang Hospital for Women and Children in Vietnam

by Hoang Thi Tran, Tuan Thanh Nguyen, Oanh Thi Xuan Nguyen, Le Thi Huynh and Roger Mathisen

Nutrients 2024, 16(24), 4402; https://doi.org/10.3390/nu16244402 - 22 Dec 2024

Viewed by 889

Abstract

Background and Objectives: Donor human milk (DHM) from a human milk bank (HMB) is used to feed low-birthweight (LBW) and preterm infants when mothers cannot provide their own breastmilk. The misuse of DHM could interfere with mothers’ breastmilk and weaken breastfeeding efforts. This [...] Read more.

Background and Objectives: Donor human milk (DHM) from a human milk bank (HMB) is used to feed low-birthweight (LBW) and preterm infants when mothers cannot provide their own breastmilk. The misuse of DHM could interfere with mothers’ breastmilk and weaken breastfeeding efforts. This study aimed to identify factors behind prolonged DHM usage during the first six years of Vietnam’s first HMB. Methods: Data were extracted from the Da Nang HMB’s digital monitoring system. We defined prolonged DHM use as four or more days in the neonatal unit and two or more days in postnatal wards. Results: Over six years, 25,420 infants received DHM, with 45.3% of the infants being female, 54.7% being male, 70.0% being born via cesarean section, and 77.2% being full-term. In the neonatal unit (n = 7001), 38.0% of infants used DHM for ≥4 days. Adjusted odds ratios (aORs) for prolonged use were 0.14 for infants weighing <1000 g, 0.78 for infants weighing 1000–<1500 g, and 0.67 for infants weighing ≥2000 g (p < 0.01), compared to those weighing 1500–<2000 g. Compared to gestational ages of 32–<34 weeks, the aORs were 0.26 for <28 weeks, 0.71 for 34–<37 weeks, and 0.35 for ≥37 weeks (p < 0.01). In postnatal wards (n = 18,419), 53.1% of infants used DHM for ≥2 days. Compared to term, normal-weight infants, the aORs were 1.25 for LBW–preterm, 1.17 for LBW–term, and 1.21 for normal-weight–preterm infants (p < 0.05). Prolonged DHM use was associated with cesarean births in neonatal units (aOR 2.24, p < 0.01) and postnatal wards (aOR 1.44, p < 0.01). Conclusions: DHM is used briefly to bridge nutritional gaps and transition to mothers’ breastmilk, but LBW, preterm births, and cesarean births are linked to prolonged use. Healthcare providers should support those at risk of prolonged DHM use and prioritize reducing unnecessary cesarean births. Full article

(This article belongs to the Special Issue Own or Donated Human Milk: Its Role in Today's Society)

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14 pages, 611 KiB

Open AccessArticle

Nutritional Status of Very Elderly Outpatients with Heart Failure and Its Influence on Prognosis

by Sonia González-Sosa, Pablo Santana-Vega, Alba Rodríguez-Quintana, Jose A. Rodríguez-González, José M. García-Vallejo, Alicia Puente-Fernández and Alicia Conde-Martel

Nutrients 2024, 16(24), 4401; https://doi.org/10.3390/nu16244401 - 21 Dec 2024

Viewed by 834

Abstract

Background/Objectives: Malnutrition has been associated with increased morbidity and mortality in elderly patients diagnosed with heart failure (HF). However, nutritional problems are underdiagnosed in these patients. This study aimed to analyse malnutrition prevalence in elderly HF patients and its impact on survival. Methods: [...] Read more.

Background/Objectives: Malnutrition has been associated with increased morbidity and mortality in elderly patients diagnosed with heart failure (HF). However, nutritional problems are underdiagnosed in these patients. This study aimed to analyse malnutrition prevalence in elderly HF patients and its impact on survival. Methods: We conducted a retrospective observational study including patients aged ≥85 years diagnosed with HF followed up by a specific HF unit between 2015 and 2023. All patients underwent a nutritional assessment at the start of follow-up. Demographic characteristics, comorbidities, functional, cognitive and frailty status, heart disease characteristics and laboratory data, as well as admissions, emergency department visits and survival, were collected. The sample was categorised according to nutritional status into normonutrition and impaired nutritional status, and differences were evaluated. Results: Of a total of 413 patients, 52.8% were female, and the mean age was 88.4 ± 2.9 years. A total of 25.4% were at risk of malnutrition and 2.2% malnourished. Dementia [OR = 3.99, 95%CI (2.32–6.86); p < 0.001], hip fracture [OR = 3.54, 95%CI (1.75–7.16); p < 0.001)], worse Barthel index score [OR = 5.44, 95%CI (3.15–9.38); p < 0.001), worse Pfeiffer test [OR = 5.45; 95%CI (3.29–9.04); p < 0.001), worse Frail index [OR = 6.19; 95%CI (2.45–15.61); p < 0.001] and higher Charlson index [OR = 1.95; 95%CI (1.21–3.15); p = 0.006] were associated with worse nutritional status. In addition, patients with poor nutritional status lived 16.69 months less (p < 0.001) than normonutrited patients. Conclusions: At least one in four elderly patients with HF under outpatient follow-up has an impaired nutritional status. This is associated with hip fracture and greater functional and cognitive decline. Patients who are malnourished or at risk of malnutrition survive less than those who are not malnourished. Full article

(This article belongs to the Section Clinical Nutrition)

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12 pages, 730 KiB

Open AccessArticle

Macronutrient Intake and Food Categories’ Contribution to Daily Energy Intake According to BMI in Primary School Children in Croatia

by Lidija Šoher, Daniela Čačić Kenjerić, Martina Pavlić, Ivana Rumbak, Nataša Šarlija, Ana Ilić and Darja Sokolić

Nutrients 2024, 16(24), 4400; https://doi.org/10.3390/nu16244400 - 21 Dec 2024

Viewed by 744

Abstract

Background: Nutritional status in childhood is associated with a number of short- and long-term health effects. The rising prevalence of childhood obesity highlights the necessity of understanding dietary patterns in children. The study provides an assessment of energy and macronutrient intake and food [...] Read more.

Background: Nutritional status in childhood is associated with a number of short- and long-term health effects. The rising prevalence of childhood obesity highlights the necessity of understanding dietary patterns in children. The study provides an assessment of energy and macronutrient intake and food categories’ contribution to energy intake in Croatian primary school children, according to BMI status. Methods: To assess dietary habits, results of the National Food Consumption Survey on Infants and Children based on EU Menu methodology (OC/EFSA/DATA/2016/02 CT3) were used. The sample included 476 children, aged 6 to under 10 years. Results: Results indicated that one in four children was overweight or obese (27.7%). In total, the mean energy intake was 1598.4 ± 380.3 kcal/day, with 30.7% of the children above the recommended energy intake. Cereals, cereal products, and potato food category were the primary sources of energy, which is in line with the recommendations, with protein and fat intakes exceeding recommended levels. Substantial contribution of sweets and low contribution of fruits and vegetables were observed across all BMI categories, with the difference in energy contribution of fruits (p = 0.041) and vegetables (p = 0.033). The meat, poultry, fish, and eggs category were the contributors to energy intake from protein and fat, in the majority of BMI groups. Conclusions: In the obese group, higher energy intake from certain food subgroups was recorded, stressing the need for a more detailed dietary assessment. The study’s cross-sectional design limits causal inferences, indicating a need for future longitudinal research to better understand the dynamics of dietary patterns and BMI status in primary school children. Full article

(This article belongs to the Section Pediatric Nutrition)

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32 pages, 11226 KiB

Open AccessReview

Long-Term Follow-Up After Bariatric Surgery: Key to Successful Outcomes in Obesity Management

by Aleksandra Budny, Agata Janczy, Michal Szymanski and Adriana Mika

Nutrients 2024, 16(24), 4399; https://doi.org/10.3390/nu16244399 - 21 Dec 2024

Viewed by 1232

Abstract

Background/Objectives: Bariatric surgery (BS) is considered one of the most effective interventions for the treatment of obesity. To achieve optimal long-term results, continuous follow-up (FU) within a multidisciplinary treatment team is essential to ensure patient compliance and maximize the benefits of BS. [...] Read more.

Background/Objectives: Bariatric surgery (BS) is considered one of the most effective interventions for the treatment of obesity. To achieve optimal long-term results, continuous follow-up (FU) within a multidisciplinary treatment team is essential to ensure patient compliance and maximize the benefits of BS. However, many patients find it difficult to maintain regular FU, which can affect the quality of care and lead to postoperative complications. This review aims to highlight factors that may hinder compliance with FU after BS, examine potential causes and consequences of inadequate FU, and identify strategies to improve patient participation in long-term FU. Methods: The literature search was conducted between October 2023 and June 2024 in Medline (PubMed) and the Cochrane Library datasets. Studies were selected for their relevance to adherence to FU, multidisciplinary approaches, and long-term bariatric outcomes. Results: The pre- and postoperative period is critical for educating patients and healthcare team members about the importance of FU, addressing potential barriers (e.g., logistical, psychological, and social challenges), and highlighting the risk of relapse to obesity after surgery. The lack of a standardized FU protocol leads to differences between medical centers, further impacting patient adherence. Conclusions: Tailored and regularly updated strategies are essential to address individual patient needs and improve adherence to FU. Further research is needed to identify the specific factors that influence variability in long-term BS outcomes, highlighting the need for a patient-centered approach to obesity treatment. Full article

(This article belongs to the Section Nutrition and Obesity)

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19 pages, 4067 KiB

Open AccessArticle

A Meal with Ultra-Processed Foods Leads to a Faster Rate of Intake and to a Lesser Decrease in the Capacity to Eat When Compared to a Similar, Matched Meal Without Ultra-Processed Foods

by Maria Bárbara Galdino-Silva, Karine Maria Moreira Almeida, Ana Debora Santos de Oliveira, João Victor Laurindo dos Santos, Mateus de Lima Macena, Dafiny Rodrigues Silva, Micnéias Roberth Pereira, André Eduardo Silva-Júnior, Débora Cavalcante Ferro, Déborah Tenório da Costa Paula, Guilherme César de Oliveira Carvalho, Marianna Victória Cerqueira Rocha, Juliane Pereira da Silva, Emiliano de Oliveira Barreto and Nassib Bezerra Bueno

Nutrients 2024, 16(24), 4398; https://doi.org/10.3390/nu16244398 - 21 Dec 2024

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Abstract

Background/Objectives: It is unknown whether the negative health effects associated with ultra-processed foods (UPFs) are due to their nutritional composition or to the extent of food processing itself. We evaluated the impact of a test meal composed only of UPF, according to [...] Read more.

Background/Objectives: It is unknown whether the negative health effects associated with ultra-processed foods (UPFs) are due to their nutritional composition or to the extent of food processing itself. We evaluated the impact of a test meal composed only of UPF, according to the NOVA classification, compared to a similar meal without UPF in adults with obesity. Methods: This is a parallel, randomized trial. Adult individuals with obesity, according to BMI, % body fat, and/or waist circumference were included. Individuals ate one out of two test meals, matched for energy density, macronutrients, sodium, and fiber, differing in NOVA classification, as a breakfast after a 12-h fast. The rate of intake, appetite, satiety hormones, energy expenditure, and autonomic function were measured. Data were analyzed using mixed analysis of variance. Results: Forty-two individuals were included. We found a significantly faster intake rate (07:52 ± 3:00 vs. 11:07 ± 03:16 min), with less chewing and bites, and greater capacity to eat (39.68 ± 22.69 vs. 23.95 ± 18.92 mm) after the UPF meal, without observed differences in the metabolic outcomes. In an exploratory analysis, after adjusting by sex, leptin levels showed a greater decrease after the test meal in the control group. Conclusions: Although we found a faster intake rate in the UPF meal, only marginal effects were found on the participants’ capacity to eat after the UPF meal. The high similarity between meals, despite differences according to the NOVA classification, may explain these results. As our study was small, these findings require further investigation. Full article

(This article belongs to the Special Issue Clinical Relevance of Ultra-Processed Food Consumption)

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Nutrients, Volume 16, Issue 24 (December-2 2024) – 175 articles

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