Table of Contents
Nutrients, Volume 11, Issue 11 (November 2019) – 289 articles
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Cover Story (view full-size image) Phenolic compounds are promising molecules for the prevention of neurodegenerative disorders. [...] Read more. Phenolic compounds are promising molecules for the prevention of neurodegenerative disorders. However, little is known about the ability of their main circulating metabolites, derived by their interaction with the gut microbiota, to reach the brain. The present work investigated the ability of phenyl--valerolactones, the main flavan-3-ol metabolites, to cross the blood-brain barrier. Five experimental models were used, with increased realism, including in silico, in vitro and in vivo animal studies. Results highlighted the blood-brain barrier permeability to one of the main flavan-3-ol microbial metabolites, namely 5-(hydroxyphenyl)-γ-valerolactone-sulfate. Further research is needed to better understand the underlying mechanism and the biological effect of this metabolite on brain cells. Nevertheless, these results help support the neuroprotective effects of phenolic-rich foods in the frame of the “gut-brain axis”.View the paper