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Open AccessArticle

Plasma versus Erythrocyte Vitamin E in Renal Transplant Recipients, and Duality of Tocopherol Species

1
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
2
Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, CP 8380453 Santiago, Chile
3
Clínica Alemana de Santiago, Universidad del Desarrollo, 7610658 Santiago, Chile
4
Division of Transplantation Surgery, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
5
Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
6
Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2821; https://doi.org/10.3390/nu11112821
Received: 1 October 2019 / Revised: 12 November 2019 / Accepted: 14 November 2019 / Published: 19 November 2019
(This article belongs to the Special Issue Vitamin E: Uses, Benefits, Emerging Aspects, and RDA)
Redox imbalance is an adverse on-going phenomenon in renal transplant recipients (RTR). Vitamin E has important antioxidant properties that counterbalance its deleterious effects. However, plasma vitamin E affinity with lipids challenges interpretation of its levels. To test the hypothesis that erythrocyte membranes represent a lipids-independent specimen to estimate vitamin E status, we performed a cross-sectional study in a cohort of adult RTR (n = 113) recruited in a university setting (2015–2018). We compared crude and total lipids-standardized linear regression-derived coefficients of plasma and erythrocyte tocopherol species in relation to clinical and laboratory parameters. Strongly positive associations of fasting lipids with plasma tocopherol became inverse, rather than absent, in total lipids-standardized analyses, indicating potential overadjustment. Whilst, no variables from the lipids domain were associated with the tocopherol species measured from erythrocyte specimens. In relation to inflammatory status and clinical parameters with antioxidant activity, we found associations in directions that are consistent with either beneficial or adverse effects concerning α- or γ-tocopherol, respectively. In conclusion, erythrocytes offer a lipids-independent alternative to estimate vitamin E status and investigate its relationship with parameters over other biological domains. In RTR, α- and γ-tocopherol may serve as biomarkers of relatively lower or higher vulnerability to oxidative stress and inflammation, noticeably in opposite directions. View Full-Text
Keywords: vitamin E; α-tocopherol; γ-tocopherol; erythrocyte; inflammation; oxidative stress; cardiovascular disease; renal transplantation; renal transplant recipients vitamin E; α-tocopherol; γ-tocopherol; erythrocyte; inflammation; oxidative stress; cardiovascular disease; renal transplantation; renal transplant recipients
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Sotomayor, C.G.; Rodrigo, R.; Gomes-Neto, A.W.; Gormaz, J.G.; Pol, R.A.; Minović, I.; Eggersdorfer, M.L.; Vos, M.; Riphagen, I.J.; de Borst, M.H.; Nolte, I.M.; Berger, S.P.; Navis, G.J.; Bakker, S.J.L. Plasma versus Erythrocyte Vitamin E in Renal Transplant Recipients, and Duality of Tocopherol Species. Nutrients 2019, 11, 2821.

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