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Gastroenterology Insights, Volume 17, Issue 4

2026 December - 11 articles

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Articles (11)

  • Article
  • Open Access

One-Year Real-World Outcomes of Biologic and Small-Molecule Therapy in Patients with Inflammatory Bowel Disease: A Single Healthcare System Experience from Bahrain

  • Ali Hussein,
  • Salman Kaladari,
  • Weqar Naser,
  • Aysha Albusaiteeni and ,
  • Nader Khawaja,
  • Naila Ahmed,
  • Amal Mohamed Almutawa,
  • Dana Alsharqi,
  • Omar Sharif and
  • Faisal Abubaker
  • + 5 authors+ 0 author

Background: Biologic and small-molecule therapies have transformed inflammatory bowel disease (IBD) management, yet real-world evidence from the Gulf region remains limited. This study evaluated 12-month clinical, biochemical, and endoscopic outcomes...

(This article belongs to the Special Issue Immunological Aspects of Gastrointestinal Diseases)
  • Review
  • Open Access
177 Views
36 Pages

Mucinous Colon Adenocarcinoma and Treatment Response: A Critical Review of Prognostic Associations and Emerging Predictive Evidence

  • Diana Maria Orzata,
  • Adrian-Iosif Moldoveanu,
  • Gabriel Veniamin Cozma,
  • Emil Florin Hut and ,
  • Radu Gheorghe Dan,
  • Ovidiu Alexandru Mederle and
  • Laurentiu Vasile Sima
  • + 2 authors+ 0 author

Mucinous adenocarcinoma (MAC) is a distinct colorectal cancer subtype characterized by specific clinicopathological and molecular features and a propensity for peritoneal dissemination. However, whether mucinous histology primarily represents a progn...

(This article belongs to the Section Alimentary Tract)
  • Article
  • Open Access
181 Views
14 Pages

Branch-Duct Intraductal Papillary Mucinous Neoplasms Measuring Less than 10 mm Exhibit a Significantly Lower Risk of Developing “Worrisome Features”

  • Frederik J. Hansen,
  • Peter Ewald,
  • Luis Sorncharoen,
  • Daniel R. Quast and ,
  • Maximilian Stögbauer,
  • Renate Schlottmann,
  • Christoph Zeidler,
  • Mousa Ayoub,
  • Bernadette Kaup and
  • Alanna Ebigbo
  • + 9 authors+ 4 authors

Background: Pancreatic carcinomas are among the malignant tumours with the highest mortality and remain associated with an extremely poor prognosis. Early identification and surveillance of premalignant lesions, such as intraductal papillary mucinous...

(This article belongs to the Special Issue Updates on Pancreatic Diseases)
  • Article
  • Open Access
445 Views
28 Pages

Background/Objectives: Transanal irrigation (TAI) is an established bowel-emptying strategy for selected patients with bowel dysfunction, whereas evidence on Colon Hydrotherapy (CHT) in chronic gastrointestinal disorders remains limited. This pilot s...

(This article belongs to the Section Gastrointestinal Disease)
  • Article
  • Open Access
232 Views
17 Pages

Background/Objectives: Contemporary data on active Helicobacter pylori infection among university students in Albania are limited. This study estimated urea breath test (UBT)-detected prevalence and described awareness, self-reported knowledge, gastr...

(This article belongs to the Section Gastrointestinal Disease)
  • Systematic Review
  • Open Access
301 Views
15 Pages

Gut Microbiome Alterations, Microbial Metabolites and Hepatobiliary Cancer: A Descriptive Systematic Review of the Microbial–Metabolic Axis

  • Christian A. Macias,
  • Aman Goyal,
  • Phillip Chehet,
  • Federico Maria Mongardini and ,
  • Nicolas Zucchini,
  • Michail Koutentakis,
  • Tushar Kanti Bhadra,
  • Qaviullah Mian,
  • Abhirami Babu and
  • Rodolfo J. Oviedo
  • + 7 authors+ 2 authors

Background: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are considered major causes of cancer-related mortality. Evidence suggests that gut microbiome dysbiosis and the microbial–metabolic axis and its metabolites in hepatic chr...

(This article belongs to the Section Liver)
  • Review
  • Open Access
565 Views
35 Pages

Early-Onset Colorectal Cancer: Molecular Features, Risk Stratification, Screening Gaps, and Personalized Prevention

  • Vanessa Lu,
  • Fiona Xu,
  • Giuliana Graziosi,
  • Elicca Rapisura and ,
  • Tanya Pai and
  • Micheal Tadros
  • + 1 author+ 0 author

Although overall colorectal cancer (CRC) incidence and mortality have declined with widespread screening, early-onset CRC (EOCRC), defined as diagnosis before age 50, continues to rise. EOCRC partially differs from late-onset CRC (LOCRC) in clinical...

(This article belongs to the Collection Advances in Gastrointestinal Cancer)
  • Review
  • Open Access
360 Views
28 Pages

Impact of Obesity and Its Treatment on Inflammatory Bowel Disease Outcomes: A Narrative Review

  • Carlo Redavid,
  • Pietro Pirro,
  • Luisa Bertin and
  • Edoardo V. Savarino

Obesity is a chronic inflammatory condition whose rising incidence has turned it into a global epidemic, a trend that also affects people living with inflammatory bowel diseases (IBD). Recent epidemiological data indicate that roughly 25 to 40% of pa...

(This article belongs to the Section Alimentary Tract)
  • Article
  • Open Access
261 Views
9 Pages

Background/Objectives: Amyloid deposition is an uncommon but clinically important complication of chronic inflammatory disorders, including inflammatory bowel disease (IBD). Because published estimates are heterogeneous and depend strongly on how tis...

(This article belongs to the Section Alimentary Tract)
  • Review
  • Open Access
408 Views
15 Pages

Pancreatic ductal adenocarcinoma (PDAC) is defined by significant desmoplastic reaction composed of cancer-associated fibroblasts (CAFs), pancreatic stellate cells (PSCs), extracellular matrix (ECM), immune cells, and abnormal vascularization. This s...

(This article belongs to the Special Issue Updates on Pancreatic Diseases)
  • Article
  • Open Access
250 Views
17 Pages

Background/Objectives: Adenoma detection rate (ADR) is a central colonoscopy quality indicator, but the extent to which annual procedural volume explains physician-level ADR remains uncertain. We evaluated the association of procedural volume with AD...

(This article belongs to the Section Gastrointestinal Disease)
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Gastroenterol. Insights - ISSN 2036-7422