Updates on Pancreatic Diseases

A Special Issue of Gastroenterology Insights (ISSN 2036-7422) belonging to the section "Pancreas".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 527

Editor


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Guest Editor
Department of Nuclear Medicine, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
Interests: cell death; autophagy; solid cancer; neuro-endocrine; epigenetics
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Special Issue Information

Dear Colleagues, 

We are pleased to invite you to submit your research to a Special Issue entitled “Updates on Pancretic Disease”. Nowadays, diseases related to the pancreas present a significant challenge to patients. Cancers affecting the exocrine and neuroendocrine pancreas still require a therapy that is both effective and less toxic in order to benefit patient survival and prognosis. The molecular mechanisms characterizing tumorigenesis have been broadly depicted, yet much remains to be discovered. The development of personalized precision therapy could be promising for patients currently in need of treatment. 

This Special Issue aims to highlight the most recent discoveries related to pancreas tumorigenesis, neuroendocrine diseases associated with MEN1 and MEN2, and neoplasia.

For this Special Issue, original research articles, reviews, and short commentaries are welcome. Research areas may include (but are not limited to) pancreatic ductal adenocarcinoma, pancreatic neuroendocrine neoplasia, pancreatic neuroendocrine dieseases, MEN1 and MEN2, and pancreatic tumorigenesis and metastasis. Both clinical and pre-clinical studies are welcome.

We look forward to receiving your contributions

Dr. Pietro Di Fazio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gastroenterology Insights is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PDAC
  • PNEN
  • MEN1
  • MEN2
  • pancreatic disease
  • precision oncology
  • personalized therapy
  • research advancement and challenge
  • preclinical study

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Published Papers (1 paper)

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Research

21 pages, 23479 KB  
Article
Pancreatic Metastases Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Biopsy: A Retrospective Single-Center Study
by Gabriela Ivanov, Madalina Ilie, Oana-Mihaela Plotogea, Gabriel Constantinescu, Christopher Pavel, Bogdan-Valeriu Popa, Valentin Enache, Raluca-Ioana Dascalu, Mariana Mihaila, Alexandru Chiotoroiu, Kamel Earar, Dorin Ioan Cocoș and Mircea Beuran
Gastroenterol. Insights 2026, 17(3), 49; https://doi.org/10.3390/gastroent17030049 - 1 Sep 2026
Viewed by 260
Abstract
Background/Objectives: Pancreatic metastases are uncommon and may resemble primary pancreatic neoplasms on imaging, making tissue confirmation essential. This study aimed to characterize pancreatic metastases diagnosed by endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) and to describe tissue adequacy within the confirmed cohort and procedure-related [...] Read more.
Background/Objectives: Pancreatic metastases are uncommon and may resemble primary pancreatic neoplasms on imaging, making tissue confirmation essential. This study aimed to characterize pancreatic metastases diagnosed by endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) and to describe tissue adequacy within the confirmed cohort and procedure-related adverse events. Methods: This retrospective, single-center study included 21 patients with histologically confirmed pancreatic metastases diagnosed by EUS-FNB between January 2021 and November 2025. Clinical data, EUS features, procedural parameters, histopathological findings, management, and outcomes were reviewed. Results: The mean age was 60.9 ± 12.9 years, and 57.1% of patients were male. Lung carcinoma was the most frequent primary tumor (33.3%), followed by renal cell carcinoma (19.0%). Most lesions were solitary (66.7%) and hypoechoic (85.7%). All 21 patients included in the final cohort had histologically adequate EUS-FNB specimens; this finding reflects the selected cohort of confirmed metastatic cases and should not be interpreted as an overall adequacy rate or measure of diagnostic performance. The mean number of needle passes was 1.14 ± 0.36. One small, asymptomatic intrapancreatic hematoma occurred and resolved conservatively. Three selected patients underwent surgical resection and were alive without evidence of disease at last follow-up; however, no inference regarding a survival benefit from surgery can be made from this small, selected subgroup. Conclusions: In this cohort of histologically confirmed pancreatic metastases, EUS-FNB provided tissue suitable for pathological characterization, with immunohistochemical analysis performed when required to determine tumor origin. The present study was not designed to estimate overall diagnostic accuracy or adequacy. Surgical resection may be considered in carefully selected patients with isolated disease, as supported by the published literature; however, the present cohort does not permit assessment of a survival benefit associated with surgery. Full article
(This article belongs to the Special Issue Updates on Pancreatic Diseases)
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