Next Article in Journal
Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains
Previous Article in Journal
Extended Release Combination Antibiotic Therapy from a Bone Void Filling Putty for Treatment of Osteomyelitis
Communication

Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative

1
College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea
2
College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea
*
Authors to whom correspondence should be addressed.
The authors contribute equally to this work.
Pharmaceutics 2019, 11(11), 593; https://doi.org/10.3390/pharmaceutics11110593
Received: 24 September 2019 / Revised: 7 November 2019 / Accepted: 8 November 2019 / Published: 9 November 2019
P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUCinf as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative can increase PTX bioavailability by inhibiting P-gp existing in eliminating organs. View Full-Text
Keywords: ferulic acid derivatives; P-glycoprotein; elimination; pharmacokinetics; bioavailability; paclitaxel ferulic acid derivatives; P-glycoprotein; elimination; pharmacokinetics; bioavailability; paclitaxel
Show Figures

Graphical abstract

MDPI and ACS Style

Lee, J.; Chae, S.W.; Ma, L.; Lim, S.Y.; Alnajjar, S.; Park Choo, H.-Y.; Lee, H.J.; Rhie, S.J. Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative. Pharmaceutics 2019, 11, 593. https://doi.org/10.3390/pharmaceutics11110593

AMA Style

Lee J, Chae SW, Ma L, Lim SY, Alnajjar S, Park Choo H-Y, Lee HJ, Rhie SJ. Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative. Pharmaceutics. 2019; 11(11):593. https://doi.org/10.3390/pharmaceutics11110593

Chicago/Turabian Style

Lee, Jaeok, Song W. Chae, LianJi Ma, So Y. Lim, Sarah Alnajjar, Hea-Young Park Choo, Hwa J. Lee, and Sandy J. Rhie. 2019. "Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative" Pharmaceutics 11, no. 11: 593. https://doi.org/10.3390/pharmaceutics11110593

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop