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Special Issue "Drug Delivery in Regenerative Medicine"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (30 June 2019).
Delivery of instructive cues to the body is one of the instrumental pillars in regenerative medicine. Growth factors stimulating resident or exogenously added cells, or factors attracting native stem cells have shown promise in several tissues, including bone, nerve and skin tissue. Drug delivery can also help in modulating the environment of regenerating tissues e.g. small molecules inhibiting harmful factors such as proinflammatory cytokines, or by stimulating blood vessel ingrowth needed for regeneration. Usually the delivery system is applied locally, which allows for high local concentrations, saves on expensive biologicals and reduces systemic side effects. As delivery vehicles, biomaterial hydrogel and solid scaffolds or nano- and microspheres can be used either or not with targeting moieties for tissue-directed modulation in complex environments. Challenges are still many; the lack of correlation of in vitro with in vivo release profiles, drug stability, the effect of the local biomaterial response, other local factors in vivo that cannot be mimicked in simple in vitro systems. Also the lack of understanding of optimal duration and dosage is a considerable hurdle still not taken.
This special issue invites manuscripts on any of these subjects, or others in the context of regenerative medicine and drug delivery approaches.
Prof. Laura B. Creemers
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.