Special Issue "Advances in Oral and Buccal Drug Delivery"
Deadline for manuscript submissions: closed (10 June 2020).
Recently, various types of medicines have been developed and become clinically available. Dosing routes of medicines are chosen based on their physico- and bio-pharmaceutical characteristics. They are often compelled to be used only via parenteral routes because of problems regarding their stabilities and biological membrane obstacles. Parenteral administration is followed by pain and stimulus, and sometimes causes toxic side effects due to inadequate drug concentration.
Oral administrations are the most patient-friendly due to ease-of-use and non-invasive dosing. However, oral administration is inadequate for drugs in which drug absorption is limited due to their physicochemical and/or biological features. In order to solve this problem of absorption efficiency (bioavailability), various physicochemical and biological approaches have been attempted, and the enhancement of the drug solubility and the modification of intestinal membrane permeability have been studied. The improvement of bioavailability or the overcoming of obstacles of intestinal absorption have been challenged a lot as essential subjects. Furthermore, recent advances in oral delivery are introduced in this Special Issue.
In addition, buccal delivery is one of the non-oral mucosal drug applications. Transmucosal delivery enables the rapid absorption and maintenance of systemic levels for a fairly long time. As buccal delivery is simpler compared with nasal, rectal, and pulmonary deliveries, it draws much attention as the second non-invasive administration. For drugs with the first pass effect and strong stimulus in injection, buccal delivery is highly advantageous to ensure such drawbacks can be avoided. Buccal delivery may be available as an alternative to parenteral dosing. Recent developments in buccal delivery are introduced in this content.
Prof. Dr. Hiraku Onishi
Manuscript Submission Information
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- oral delivery—amorphous and cocrystal
- oral delivery—transporter and absorption enhancer
- oral delivery—protein and peptide absorption
- oral delivery—colonic delivery
- oral delivery—prodrugs
- buccal delivery—droplets, emulsions, suspensions, and liposomes
- buccal delivery—buccal tablets, films, and ointments
- buccal delivery—absorption enhancers, and mucoadhesive polymers
- buccal delivery—prodrugs