Next Article in Journal
Two New Alginate Lyases of PL7 and PL6 Families from Polysaccharide-Degrading Bacterium Formosa algae KMM 3553T: Structure, Properties, and Products Analysis
Previous Article in Journal
Mining the Metabolome and the Agricultural and Pharmaceutical Potential of Sea Foam-Derived Fungi
Previous Article in Special Issue
Monarubins A–C from the Marine Shellfish-Associated Fungus Monascus ruber BB5
Open AccessArticle

Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae

Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
Institute of Physiological Chemistry, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany
Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, 420281 Awka, Nigeria
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(2), 129;
Received: 5 February 2020 / Revised: 19 February 2020 / Accepted: 20 February 2020 / Published: 23 February 2020
Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I–Q (19) and cytosporins O–W (1523), together with eight known analogs (1014 and 2426). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher’s method was applied to determine the absolute configuration of some compounds. Compound 23 showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC50 value of 3.0 μM. Furthermore, compounds 22 and 23 showed moderate antibacterial activity against drug-resistant Acinetobacter baumannii (ATCC BAA-1605) in combination with sublethal colistin concentrations. View Full-Text
Keywords: Pseudopestalotiopsis theae; endophytic fungus; polyketide; cytotoxicity Pseudopestalotiopsis theae; endophytic fungus; polyketide; cytotoxicity
Show Figures

Figure 1

MDPI and ACS Style

Yu, X.; Müller, W.E.G.; Meier, D.; Kalscheuer, R.; Guo, Z.; Zou, K.; Umeokoli, B.O.; Liu, Z.; Proksch, P. Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae. Mar. Drugs 2020, 18, 129.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop