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Open AccessArticle

Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae

1
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, 40225 Duesseldorf, Germany
2
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
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Institute of Physiological Chemistry, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany
4
Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, 420281 Awka, Nigeria
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(2), 129; https://doi.org/10.3390/md18020129
Received: 5 February 2020 / Revised: 19 February 2020 / Accepted: 20 February 2020 / Published: 23 February 2020
Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I–Q (19) and cytosporins O–W (1523), together with eight known analogs (1014 and 2426). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher’s method was applied to determine the absolute configuration of some compounds. Compound 23 showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC50 value of 3.0 μM. Furthermore, compounds 22 and 23 showed moderate antibacterial activity against drug-resistant Acinetobacter baumannii (ATCC BAA-1605) in combination with sublethal colistin concentrations. View Full-Text
Keywords: Pseudopestalotiopsis theae; endophytic fungus; polyketide; cytotoxicity Pseudopestalotiopsis theae; endophytic fungus; polyketide; cytotoxicity
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Yu, X.; Müller, W.E.G.; Meier, D.; Kalscheuer, R.; Guo, Z.; Zou, K.; Umeokoli, B.O.; Liu, Z.; Proksch, P. Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae. Mar. Drugs 2020, 18, 129.

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