Table of Contents
Mar. Drugs, Volume 16, Issue 11 (November 2018)
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Cover Story (view full-size image) The white seabream Diplodus sargus, which is a native Mediterranean fish and a fishery resource, [...] Read more. The white seabream Diplodus sargus, which is a native Mediterranean fish and a fishery resource, has changed its alimentary habits consuming large amounts of the invasive alga Caulerpa cylindracea, and the novel diet correlates with metabolic and behavioral disorders in the fish. Here, we show that the C. cylindracea alkaloid caulerpin interacts with peroxisome proliferator-activated receptors involved in the regulation of a variety of biological processes, including metabolism and social behavior. This work could serve as a paradigmatic model in the study of biological invasions at the molecular level, disclosing molecular interactions likely to exert cascade effects from molecules to ecosystems, up to the sea-based economy. Our results are also of interest for the valorization of the biomasses from C. cylindracea into functional foods or drugs for treating human chronic diseases. View this paper.