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Open AccessArticle

Diphenyl Ethers from a Marine-Derived Aspergillus sydowii

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen 361102, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2018, 16(11), 451;
Received: 24 October 2018 / Revised: 14 November 2018 / Accepted: 14 November 2018 / Published: 16 November 2018
(This article belongs to the Special Issue Isolation and Structure Elucidation of Marine Secondary Metabolites)
Six new diphenyl ethers (16) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 13 was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds 1, 5, 6, and 811 were found to exhibit selective cytotoxicity against different cancer cell lines. View Full-Text
Keywords: Aspergillus sydowii; fungal natural product; diphenyl ethers; structure elucidation; cytotoxicity Aspergillus sydowii; fungal natural product; diphenyl ethers; structure elucidation; cytotoxicity
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Wang, Y.-N.; Mou, Y.-H.; Dong, Y.; Wu, Y.; Liu, B.-Y.; Bai, J.; Yan, D.-J.; Zhang, L.; Feng, D.-Q.; Pei, Y.-H.; Hu, Y.-C. Diphenyl Ethers from a Marine-Derived Aspergillus sydowii. Mar. Drugs 2018, 16, 451.

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