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Mar. Drugs 2018, 16(11), 451; https://doi.org/10.3390/md16110451

Diphenyl Ethers from a Marine-Derived Aspergillus sydowii

1
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3
State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen 361102, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 24 October 2018 / Revised: 14 November 2018 / Accepted: 14 November 2018 / Published: 16 November 2018
(This article belongs to the Special Issue Isolation and Structure Elucidation of Marine Secondary Metabolites)
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Abstract

Six new diphenyl ethers (16) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 13 was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds 1, 5, 6, and 811 were found to exhibit selective cytotoxicity against different cancer cell lines. View Full-Text
Keywords: Aspergillus sydowii; fungal natural product; diphenyl ethers; structure elucidation; cytotoxicity Aspergillus sydowii; fungal natural product; diphenyl ethers; structure elucidation; cytotoxicity
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Wang, Y.-N.; Mou, Y.-H.; Dong, Y.; Wu, Y.; Liu, B.-Y.; Bai, J.; Yan, D.-J.; Zhang, L.; Feng, D.-Q.; Pei, Y.-H.; Hu, Y.-C. Diphenyl Ethers from a Marine-Derived Aspergillus sydowii. Mar. Drugs 2018, 16, 451.

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