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Mar. Drugs 2018, 16(11), 454; https://doi.org/10.3390/md16110454

Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines

1
School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand
2
Department of Neurobiology, Tel-Aviv University, Ramat-Aviv 69978, Israel
3
School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand
4
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, Xinjiang, China
5
Key Laboratory of Medical Molecular Virology of MOE/MOH, Shanghai Medical College, Fudan University, 130 Dong An Road, Shanghai 200032, China
6
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, Shaanxi, China
7
College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, China
8
Institute of Biomedical Technology, Auckland University of Technology, Auckland 1010, New Zealand
9
College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518071, China
*
Author to whom correspondence should be addressed.
Received: 19 October 2018 / Revised: 13 November 2018 / Accepted: 15 November 2018 / Published: 18 November 2018
(This article belongs to the Special Issue Pre-Clinical Marine Drug Discovery)
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Abstract

Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various antioxidant, anticoagulant, antiviral, and anticancer functions. In this study, we focused on low molecular weight fucoidan (LMWF) which was extracted from New Zealand Undaria pinnatifida, and investigated its anti-proliferative effects, combined with a quadruplex-forming oligonucleotide aptamer (GroA, AS1411), a powerful cell surface Nucleolin inhibitor, in prostate cancer cells. We examined LMWF (<10 kDa) and compared it with laboratory grade Fucoidan purchased from Sigma (FS), all extracted from the same seaweed species U. pinnatifida. We found that LMWF significantly improved the anti-proliferative effect of GroA, as it decreased cancer cell growth and viability and increased cell death. This research may provide the foundation for LMWF to be used against prostate cancers as a supplement therapy in combination with other therapeutic agents. View Full-Text
Keywords: fucoidan; low molecular weight fucoidan; Nucleolin; GroA; prostate cancer; Undaria pinnatifida fucoidan; low molecular weight fucoidan; Nucleolin; GroA; prostate cancer; Undaria pinnatifida
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Yang, X.; Wang, S.; Trangle, S.S.; Li, Y.; White, W.L.; Li, J.; Ying, T.; Kong, Q.; Zhao, Y.; Lu, J. Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines. Mar. Drugs 2018, 16, 454.

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