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Mar. Drugs 2018, 16(11), 456; https://doi.org/10.3390/md16110456

Cacolides: Sesterterpene Butenolides from a Southern Australian Marine Sponge, Cacospongia sp.

Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
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Received: 26 October 2018 / Revised: 15 November 2018 / Accepted: 15 November 2018 / Published: 20 November 2018
(This article belongs to the Special Issue Marine Natural Products Discovery: In Honor of Late Prof. Tatsuo Higa)
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Abstract

Chemical analysis of a marine sponge, Cacospongia sp. (CMB-03404), obtained during deep sea commercial fishing activities off the southern coast of Australia, yielded an unprecedented family of sesterterpene α-methyl-γ-hydroxybutenolides, cacolides A–L (112), together with biosynthetically related norsesterterpene carboxylic acids, cacolic acids A–C (1315). Structures were assigned on the basis of detailed spectroscopic analysis with comparisons to known natural products and biosynthetic considerations. In addition to revealing new chemical diversity, this study provided a valuable platform for comparing and contrasting the capabilities of the traditional dereplication technologies of HPLC-DAD, HPLC-MS and NMR, with those of the emerging HPLC-MS/MS approach known as global natural products social molecular networking (GNPS), as applied to marine sponge sesterterpene tetronic acids. View Full-Text
Keywords: Cacospongia sp.; sesterterpene butenolides; dereplication; GNPS; sesterterpene tetronic acids Cacospongia sp.; sesterterpene butenolides; dereplication; GNPS; sesterterpene tetronic acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Khushi, S.; Nahar, L.; Salim, A.A.; Capon, R.J. Cacolides: Sesterterpene Butenolides from a Southern Australian Marine Sponge, Cacospongia sp.. Mar. Drugs 2018, 16, 456.

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