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Mar. Drugs 2018, 16(11), 458; https://doi.org/10.3390/md16110458

Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease

1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia
2
School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia
These authors contributed equally to the work.
*
Author to whom correspondence should be addressed.
Received: 25 October 2018 / Revised: 9 November 2018 / Accepted: 19 November 2018 / Published: 21 November 2018
(This article belongs to the Special Issue Selected Papers from the 3rd International Symposium on Life Science)
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Abstract

Four new oxysterols 14 along with previously known oxygenated sterols 514 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 14 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 114 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated. View Full-Text
Keywords: secondary metabolites; oxygenated steroids; marine sponge; Inflatella; NMR; ROS; Parkinson’s disease; structure-activity relationship secondary metabolites; oxygenated steroids; marine sponge; Inflatella; NMR; ROS; Parkinson’s disease; structure-activity relationship
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Kolesnikova, S.A.; Lyakhova, E.G.; Kalinovsky, A.I.; Popov, R.S.; Yurchenko, E.A.; Stonik, V.A. Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease. Mar. Drugs 2018, 16, 458.

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