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Pharmaceuticals, Volume 18, Issue 9

September 2025 - 183 articles

Cover Story: The 1,3,4-thiadiazole scaffold has emerged as a privileged structure in medicinal chemistry due to its unique electronic features, balanced physicochemical properties, and broad pharmacological potential. Its ability to modulate enzymes, interact with receptors, and disrupt microbial pathways underlies diverse antibacterial and antifungal effects. In recent years, numerous 1,3,4-thiadiazole derivatives have been synthesized and evaluated, demonstrating high levels of activity against Gram-positive and Gram-negative bacteria as well as a wide range of fungal species. This review highlights recent advances in the design, synthesis, and biological evaluation of such compounds. View this paper
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Articles (183)

  • Article
  • Open Access
745 Views
24 Pages

18 September 2025

Background/Objectives: Prostate and bladder cancers are significant global health challenges with increasing incidence and limited treatment options in advanced stages. Drug repurposing offers a cost-effective strategy to accelerate the development o...

  • Article
  • Open Access
561 Views
12 Pages

Evaluation of Proliferative Activity of Hawaiian Plants on PC-12 and Neuro-2a Cells and Their Effect on the TPH and TH Genes

  • Pornphimon Meesakul,
  • Tyler Shea,
  • Xiaohua Wu,
  • Yutaka Kuroki,
  • Aya Wada and
  • Shugeng Cao

18 September 2025

Background/Objectives: Neurotransmitters such as dopamine and serotonin are critical regulators of mood, cognition, and neuronal homeostasis. This study aimed to evaluate the neuropharmacological potential of Hawaiian plants by investigating their ab...

  • Comment
  • Open Access
1 Citations
932 Views
5 Pages

18 September 2025

In response to the recent meta-analysis by Tassi et al. on hormonal contraception and bone metabolism, we raise critical concerns regarding the interpretation of bone turnover markers as surrogates for bone mineral density (BMD). While bone turnover...

  • Retraction
  • Open Access
465 Views
2 Pages

RETRACTED: Naamneh et al. Structure–Activity Relationship of Synthetic Linear KTS-Peptides Containing Meta-Aminobenzoic Acid as Antagonists of α1β1 Integrin with Anti-Angiogenic and Melanoma Anti-Tumor Activities. Pharmaceuticals 2024, 17, 549

  • Majdi Saleem Naamneh,
  • Tatjana Momic,
  • Michal Klazas,
  • Julius Grosche,
  • Johannes A. Eble,
  • Cezary Marcinkiewicz,
  • Netaly Khazanov,
  • Hanoch Senderowitz,
  • Amnon Hoffman and
  • Chaim Gilon
  • + 2 authors

18 September 2025

The journal retracts the article titled “Structure–Activity Relationship of Synthetic Linear KTS-Peptides Containing Meta-Aminobenzoic Acid as Antagonists of α1β1 Integrin with Anti-Angiogenic and Melanoma Anti-Tumor Activities...

  • Opinion
  • Open Access
2,461 Views
40 Pages

Cardiotoxicity Induced by Anticancer Therapies: A Call for Integrated Cardio-Oncology Practice

  • Giuliana Ciappina,
  • Luigi Colarusso,
  • Enrica Maiorana,
  • Alessandro Ottaiano,
  • Tindara Franchina,
  • Antonio Picone,
  • Gaetano Facchini,
  • Chiara Barraco,
  • Antonio Ieni and
  • Maurizio Cusmà Piccione
  • + 2 authors

17 September 2025

The introduction of novel oncologic therapies, including targeted agents, immunotherapies, and antibody–drug conjugates, has transformed the therapeutic landscape of cancer care. This evolution has resulted in a dual clinical scenario; while su...

  • Viewpoint
  • Open Access
952 Views
9 Pages

PROTACs and Glues: Striking Perspectives for Engineering Cancer Therapy À La Carte

  • Jean-Marc Ferrero,
  • Jocelyn Gal,
  • Baharia Mograbi and
  • Gérard Milano

17 September 2025

PROTACs are bifunctional small molecules that simultaneously bind a target protein and a component of the ubiquitin–proteasome system, thereby inducing selective degradation of the target. They represent a class of compounds capable of achievin...

  • Article
  • Open Access
834 Views
26 Pages

Design, Synthesis, and Biological Evaluation of Novel Multitarget 7-Alcoxyamino-3-(1,2,3-triazole)-coumarins as Potent Acetylcholinesterase Inhibitors

  • Nathalia F. Nadur,
  • Larissa de A. P. Ferreira,
  • Daiana P. Franco,
  • Luciana L. de Azevedo,
  • Lucas Caruso,
  • Thiago da S. Honório,
  • Priscila de S. Furtado,
  • Alice Simon,
  • Lucio M. Cabral and
  • Tobias Werner
  • + 2 authors

17 September 2025

Background: Multitarget-directed ligands (MTDLs), particularly those combining cholinesterase inhibition with additional mechanisms, are promising candidates for Alzheimer’s disease (AD) therapy. Based on our previous identification of a dual-a...

  • Article
  • Open Access
2,248 Views
18 Pages

Herbal Medicine and Lifestyle Modifications for People with Obesity: A Single-Center, Retrospective, Observational Study

  • Minwoo Bang,
  • Suyong Shin,
  • Jungsang Kim,
  • Minwhee Kang,
  • Donghun Lee,
  • Junho Kim,
  • Chunghee Kim,
  • Jiyoung Son,
  • Seungyeon Choi and
  • Seonghyeon Jeon
  • + 3 authors

17 September 2025

Objectives: Conventional Western treatments for obesity are associated with various adverse events (AEs). This study aimed to determine the treatment response and safety assessment of an integrative Korean medicine treatment (IKMT), consisting of her...

  • Article
  • Open Access
835 Views
23 Pages

Phlorizin Alleviates Depression-like Behaviors via Gut Microbiota Reprogramming-Induced Methionine to Inhibit Neuroinflammation in Mice Hippocampus

  • Lingling Li,
  • Jianxin Chen,
  • Xinyu Zhang,
  • Xuya Zhang,
  • Yan Fu,
  • Hong Jiang,
  • Tianxing Yin,
  • Yali Zhang,
  • Xue Li and
  • Mengyuan Hu
  • + 1 author

17 September 2025

Background: Depression is associated to gut microbiota imbalance. Our research examined the antidepressant potential of phlorizin (PHZ), a natural anti-inflammatory compound that influences gut microbiota, and explored its underlying mechanisms. Meth...

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Pharmaceuticals - ISSN 1424-8247