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Pharmaceuticals, Volume 10, Issue 1 (March 2017) – 32 articles
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Cover Story (view full-size image) Radiotheranostics combining diagnostic imaging and radiotherapeutic treatment fulfil the criteria [...] Read more. Radiotheranostics combining diagnostic imaging and radiotherapeutic treatment fulfil the criteria of personalized medicine on molecular level. In particular, peptide receptor targeting mechanism has demonstrated strong potential in the clinical management of neuroendocrine neoplasms (NENs) wherein radiolabeled somatostatin analogs targeting somatostatin receptors (SSTR) has entered clinical practice. Other receptors expressed in various NENs such as Glucagon-Like Peptide-1 Receptor and Cholecystokinin-2 receptor approached clinical research, and Glucose-Dependent Insulinotropic Polypeptide (GIP) receptor has the potential for SSTR-negative and GLP-1R-negative NENs. The current status of radiotheranostics in NENs proves that peptide-receptor targeting nuclear imaging and therapy is an indispensable clinical tool in oncology. View this paper