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188Re(V) Nitrido Radiopharmaceuticals for Radionuclide Therapy

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara 44121, Italy
Italy and Legnaro National Laboratories, Italian National Institute for Nuclear Physics (LNL-INFN), Legnaro (PD) 35020, Italy
Author to whom correspondence should be addressed.
Academic Editors: Klaus Kopka and Elisabeth Eppard
Pharmaceuticals 2017, 10(1), 12;
Received: 7 December 2016 / Revised: 9 January 2017 / Accepted: 16 January 2017 / Published: 19 January 2017
The favorable nuclear properties of rhenium-188 for therapeutic application are described, together with new methods for the preparation of high yield and stable 188Re radiopharmaceuticals characterized by the presence of the nitride rhenium core in their final chemical structure. 188Re is readily available from an 188W/188Re generator system and a parallelism between the general synthetic procedures applied for the preparation of nitride technetium-99m and rhenium-188 theranostics radiopharmaceuticals is reported. Although some differences between the chemical characteristics of the two metallic nitrido fragments are highlighted, it is apparent that the same general procedures developed for the labelling of biologically active molecules with technetium-99m can be applied to rhenium-188 with minor modification. The availability of these chemical strategies, that allow the obtainment, in very high yield and in physiological condition, of 188Re radiopharmaceuticals, gives a new attractive prospective to employ this radionuclide for therapeutic applications. View Full-Text
Keywords: rhenium-188; theranostics; radiopharmaceuticals; radionuclide therapy; peptides; bioconjugates rhenium-188; theranostics; radiopharmaceuticals; radionuclide therapy; peptides; bioconjugates
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MDPI and ACS Style

Boschi, A.; Martini, P.; Uccelli, L. 188Re(V) Nitrido Radiopharmaceuticals for Radionuclide Therapy. Pharmaceuticals 2017, 10, 12.

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