Table of Contents
Sensors, Volume 20, Issue 5 (March-1 2020) – 303 articles
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Cover Story (view full-size image) Raman spectroscopy is a powerful optical detection technique widely used in biological research, [...] Read more. Raman spectroscopy is a powerful optical detection technique widely used in biological research, pharmaceutics, chemical sciences, and many other fields for material characterization. We introduce a freeform-segmented reflector design that works together with a microfluidic lab-on-chip for conventional and surface-enhanced Raman spectroscopy (SERS) analysis to reduce the size and cost compared to traditional bulky Raman equipment. The microfluidic chip consists of three layers: a polymer-based bottom and top sealing layer, and a channel layer for the fluidic sample under test. The maskless reactive ion etched nano-pillars with Au coating are used as the SERS substrate that is integrated inside the microfluidic chamber by UV curing adhesive. By tuning the height of the segmented reflector, we placed the focal point right on the surface of the SERS substrate to obtain the greatest enhancement. View this paper