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International Journal of Molecular Sciences, Volume 24, Issue 12

June-2 2023 - 632 articles

Cover Story: Diabetes is a global health issue causing morbidity and mortality. Diabetic retinopathy (DR) leads to preventable blindness in developed nations. The ocular surface of diabetic eyes is often overlooked, despite being prone to injury. Inflammatory changes in the corneas of diabetic patients indicate that inflammation plays a significant role in diabetic complications, much like in DR. The eye's immune privilege normally maintains immune balance, but chronic inflammation from diabetes disrupts immune regulation. This review summarizes the impact of diabetes on the ocular immune system, including immune cells and inflammatory mediators. View this paper
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Articles (632)

  • Review
  • Open Access
10 Citations
4,897 Views
22 Pages

Osteopetrosis is a group of genetic bone disorders characterized by increased bone density and defective bone resorption. Osteopetrosis presents a series of clinical manifestations, including craniofacial deformities and dental problems. However, few...

  • Article
  • Open Access
5 Citations
2,410 Views
15 Pages

Identification and Functional Characterization of ZmSCYL2 Involved in Phytosterol Accumulation in Plants

  • Chenchen Zhang,
  • Wanlu Ma,
  • Minyan Xu,
  • Tao Li,
  • Guomin Han,
  • Longjiang Gu,
  • Meng Chen,
  • Mengting Zhang,
  • Beijiu Cheng and
  • Xin Zhang

Phytosterols are natural active substances widely found in plants and play an important role in hypolipidemia, antioxidants, antitumor, immunomodulation, plant growth, and development. In this study, phytosterols were extracted and identified from th...

  • Article
  • Open Access
2 Citations
2,349 Views
21 Pages

Primary bud necrosis of grape buds is a physiological disorder that leads to decreased berry yield and has a catastrophic impact on the double cropping system in sub-tropical areas. The pathogenic mechanisms and potential solutions remain unknown. In...

  • Review
  • Open Access
2 Citations
2,605 Views
16 Pages

Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives

  • Tiziana Ciarambino,
  • Pietro Crispino,
  • Gaetano Leto,
  • Giovanni Minervini,
  • Ombretta Para and
  • Mauro Giordano

The global prevalence of overweight and obesity has dramatically increased in the last few decades, with a significant socioeconomic burden. In this narrative review, we include clinical studies aiming to provide the necessary knowledge on the role o...

  • Article
  • Open Access
6 Citations
2,757 Views
18 Pages

Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease

  • Alessandra Fiorillo,
  • Juan-José Gallego,
  • Franc Casanova-Ferrer,
  • Carla Giménez-Garzó,
  • Amparo Urios,
  • Maria-Pilar Ballester,
  • Lucia Durbán,
  • Maria-Pilar Rios,
  • Javier Megías and
  • Teresa San Miguel
  • + 5 authors

Patients with nonalcoholic fatty liver disease (NAFLD) may show mild cognitive impairment (MCI). The mechanisms involved remain unclear. The plasma concentrations of several cytokines and chemokines were measured in 71 NAFLD patients (20 with and 51...

  • Article
  • Open Access
3 Citations
3,863 Views
21 Pages

Novel Molecular Vehicle-Based Approach for Cardiac Cell Transplantation Leads to Rapid Electromechanical Graft–Host Coupling

  • Aleria Aitova,
  • Serafima Scherbina,
  • Andrey Berezhnoy,
  • Mikhail Slotvitsky,
  • Valeriya Tsvelaya,
  • Tatyana Sergeeva,
  • Elena Turchaninova,
  • Elizaveta Rybkina,
  • Sergey Bakumenko and
  • Ilya Sidorov
  • + 8 authors

Myocardial remodeling is an inevitable risk factor for cardiac arrhythmias and can potentially be corrected with cell therapy. Although the generation of cardiac cells ex vivo is possible, specific approaches to cell replacement therapy remain unclea...

  • Article
  • Open Access
6 Citations
4,069 Views
18 Pages

The accurate diagnosis and treatment of oral squamous cell carcinoma (OSCC) requires an understanding of its genomic alterations. Liquid biopsies, especially cell-free DNA (cfDNA) analysis, are a minimally invasive technique used for genomic profilin...

  • Article
  • Open Access
8 Citations
2,819 Views
17 Pages

Genome-Wide Association Study of Lint Percentage in Gossypium hirsutum L. Races

  • Yuanyuan Wang,
  • Xinlei Guo,
  • Xiaoyan Cai,
  • Yanchao Xu,
  • Runrun Sun,
  • Muhammad Jawad Umer,
  • Kunbo Wang,
  • Tengfei Qin,
  • Yuqing Hou and
  • Yuhong Wang
  • + 5 authors

Lint percentage is one of the most essential yield components and an important economic index for cotton planting. Improving lint percentage is an effective way to achieve high-yield in cotton breeding worldwide, especially upland cotton (Gossypium h...

  • Review
  • Open Access
10 Citations
29,581 Views
12 Pages

Arrhythmias after COVID-19 Vaccination: Have We Left All Stones Unturned?

  • Nino Cocco,
  • Gregor Leibundgut,
  • Francesco Pelliccia,
  • Valeria Cammalleri,
  • Annunziata Nusca,
  • Fabio Mangiacapra,
  • Giulio Cocco,
  • Valerio Fanale,
  • Gian Paolo Ussia and
  • Francesco Grigioni

SARS-CoV-2 vaccination offered the opportunity to emerge from the pandemic and, thereby, worldwide health, social, and economic disasters. However, in addition to efficacy, safety is an important issue for any vaccine. The mRNA-based vaccine platform...

  • Review
  • Open Access
14 Citations
4,948 Views
21 Pages

Genetic and Epigenetic Mechanisms of Longevity in Forest Trees

  • Anastasia Y. Batalova and
  • Konstantin V. Krutovsky

Trees are unique in terms of development, sustainability and longevity. Some species have a record lifespan in the living world, reaching several millennia. The aim of this review is to summarize the available data on the genetic and epigenetic mecha...

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Int. J. Mol. Sci. - ISSN 1422-0067