Oral Squamous Cell Carcinoma—Pathogenetic, Diagnostic and Therapeutic Perspectives

Dear Colleagues, 

Oral Squamous Cell Carcinoma (OSCC), the most common form of head and neck cancer, remains one of the major challenges of modern medicine, despite all progressed made during the last decades in cancer control for other types of malignancies. Statistical data show that the incidence of OSCC is continuously rising, while the prognosis has not improved significantly, with important mortality rates, especially associated with advanced disease at the moment of diagnosis. Some aspects regarding the carcinogenesis process in OSCC have been elucidated. Today we know that lesions of OSCC imply multiple genetic alterations in combination with exposure to behaviour or environmental risk factors. However, the exact mechanisms leading to cancer development and, more importantly, the elements which influence the response to therapy are far from being unveiled. Several questions remain unanswered: Who will suffer from OSCC during their lifetime? or How to increase the response to therapy rate in OSCC patients?

This Special issue aims to gather the most recent research conducted in the complex domain of molecular mechanisms that impact carcinogenesis, response to therapy and prognosis in OSCC. Experimental studies, as well as clinical submissions with biomolecular experiments are within the scope of our Special issue and are welcomed for submission. All authors are invited to send their research related to the topic of our Special issue, both original and review articles, to be assessed and included in the peer review process of our journal. 

Prof. Dr. Ana Caruntu
Prof. Dr. Shun-Fa Yang
Dr. Julio Acero
Guest Editors

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