Dear Colleagues,

Prostaglandins are products of polyunsaturated fatty acid metabolism, particularly arachidonic acid released from membrane phospholipids through the action of phospholipase A2 in response to a variety of chemical, physical, and neurohormonal factors. Arachidonic acid is rapidly metabolized to oxygenated products by two distinct enzymatic pathways: cyclooxygenase and lipoxygenase. The intermediate cyclooxygenase products are converted to primary prostaglandins. The generation of various prostaglandins varies from tissue to tissue and exerts a broad spectrum of effects, including cardiovascular, respiratory, gastrointestinal and neuromodulatory. In addition, prostaglandins regulate pain, uterus and urinary bladder contraction, fever, and important physiopathological processes, including inflammation and cancer progression. Many diseases result from the imbalanced or increased production of prostaglandins. Pharmacological modulation of prostaglandin levels represents a fundamental weapon in the treatment of several pathological conditions, and the development of new specific and selective drugs with low side effects is a goal of pharmacological research.

Suitable topics include but are not limited to the development of new cyclooxygenase inhibitors, the discovery of cyclooxygenase inhibitors, the pharmacological modulation of prostaglandins levels, the identification of prostaglandin synthase inhibitors, and the pharmacological characterization of specific prostaglandin receptor agonists or antagonists.

Dr. Federica Finetti
Dr. Lorenza Trabalzini
Guest Editors

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• anti-inflammatory drugs
• prostaglandin level modulators
• agonists and antagonists of prostaglandin receptors
• chronic inflammatory diseases
• cardiovascular diseases
• neuroinflammation
• autoimmune diseases
• gastrointestinal diseases
• respiratory tract
• cancer