Table of Contents
Int. J. Mol. Sci., Volume 21, Issue 9 (May-1 2020) – 375 articles
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Cover Story (view full-size image) Novel cobalt coordination compounds based on bumetanide and indomethacin therapeutic agents have [...] Read more. Novel cobalt coordination compounds based on bumetanide and indomethacin therapeutic agents have been designed and synthesized. The anti-inflammatory effects of metal complexes with this ligand were assayed in lipopolysaccharide stimulated RAW 264.7 macrophages. Both compounds show anti-diabetic activity with low in vitro cell toxicities. The formation of metal complexes with bioactive ligands is a new and promising strategy to find new compounds with high and enhanced biochemical properties. View this paper