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Open AccessArticle

Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production

1
COSMAX BTI R&I Center, #902, Pangyo inno valley E, 255, Pangyo-ro, Bundang-gu, Seongnam-si 13486, Gyeonggi-do, Korea
2
CoSeedBioPharm Co. Ltd. 68, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28161, Chungbuk, Korea
*
Authors to whom correspondence should be addressed.
These authors equally contributed to this work.
Int. J. Mol. Sci. 2020, 21(9), 3383; https://doi.org/10.3390/ijms21093383
Received: 12 March 2020 / Revised: 29 April 2020 / Accepted: 4 May 2020 / Published: 11 May 2020
(This article belongs to the Special Issue Molecular Mechanisms of Skin Aging)
In this study, caviar (sturgeon eggs) was used to elucidate its roles in adiponectin production and skin anti-aging. Recently, caviar has been largely used not only as a nutritional food, but also in cosmetic products. In particular, it has been reported that docosahexaenoic acid (DHA), as one of the main phospholipid components of caviar extract, induces intracellular lipid accumulation and the expression of adiponectin in adipocytes. Although adipocytes are well known to be associated with the skin dermis by secreting various factors (e.g., adiponectin), the effects of caviar extract and DHA on the skin are not well studied. Here, we demonstrate the effects of caviar extract and DHA on adipocyte differentiation and adiponectin production, resulting in a preventive role in UV-irradiated skin aging. Caviar extract and DHA enhanced adipocyte differentiation and promoted the synthesis of transcription factors controlling adipocyte differentiation and adiponectin. In addition, the mRNA expression levels of matrix metalloproteinase-1 (MMP-1) were decreased in UVB-irradiated Hs68 fibroblasts that were cultured in conditioned medium from caviar extract or DHA-treated differentiated adipocytes. Taken together, these results indicate that caviar extract and DHA induce adipocyte differentiation and adiponectin production, thereby inhibiting UVB-induced premature skin aging via the suppression of MMP-1 production. View Full-Text
Keywords: caviar extract; DHA; adiponectin; adipocyte differentiation; skin aging; MMP caviar extract; DHA; adiponectin; adipocyte differentiation; skin aging; MMP
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MDPI and ACS Style

Lee, K.-E.; Nho, Y.-H.; Yun, S.K.; Park, S.-M.; Kang, S.; Yeo, H. Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production. Int. J. Mol. Sci. 2020, 21, 3383.

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