Int. J. Mol. Sci., Volume 21, Issue 10 (May-2 2020) – 334 articles
Cover Story (view full-size image): In the context of a cell infected by a coronavirus, a cartoon symbolizing a papain-like protease (PLP) is shown while interacting with other proteins to promote the infection and highlighted as a drug target. In our study, we review the cysteine protease, deubiquitinating and deISGylating activities of PLPs, involved in processing the viral polyprotein of the replication complex in its active elements and dysregulating the immune response of the host cell. Therefore, we also propose a list of PLP inhibitors, which may be a therapeutic option for coronavirus infections, including COVID-19. View this paper
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