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Volume 21
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Review

The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies

by
Sherien M. El-Daly
1,2,†,
Recep Bayraktar
1,†,
Simone Anfossi
1 and
George A. Calin
1,3,4,*
1
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2
Department of Medical Biochemistry, Medical Research Division, National Research Centre, Cairo 12622, Egypt
3
Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA
4
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
†
Contributed equally.
Int. J. Mol. Sci. 2020, 21(9), 3387; https://doi.org/10.3390/ijms21093387
Submission received: 16 March 2020 / Revised: 22 April 2020 / Accepted: 7 May 2020 / Published: 11 May 2020
(This article belongs to the Special Issue The Importance of Tumor-Host Interactions in Adult B-Cell Leukemias and Lymphomas)
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Abstract

An increased focus is being placed on the tumorigenesis and contexture of tumor microenvironment in hematopoietic and solid tumors. Despite recent clinical revolutions in adoptive T-cell transfer approaches and immune checkpoint blockade, tumor microenvironment is a major obstacle to tumor regression in B-cell malignancies. A transcriptional alteration of coding and non-coding RNAs, such as microRNAs (miRNAs), has been widely demonstrated in the tumor microenvironment of B-cell malignancies. MiRNAs have been associated with different clinical-biological forms of B-cell malignancies and involved in the regulation of B lymphocyte development, maturation, and function, including B-cell activation and malignant transformation. Additionally, tumor-secreted extracellular vesicles regulate recipient cell functions in the tumor microenvironment to facilitate metastasis and progression by delivering miRNA contents to neighboring cells. Herein, we focus on the interplay between miRNAs and tumor microenvironment components in the different B-cell malignancies and its impact on diagnosis, proliferation, and involvement in treatment resistance.
Keywords: B-cell malignancies; tumor microenvironment; stroma; microRNAs; cell-to-cell communication; exosomal miRNAs; immune cells; endothelial cells; cancer-associated fibroblasts B-cell malignancies; tumor microenvironment; stroma; microRNAs; cell-to-cell communication; exosomal miRNAs; immune cells; endothelial cells; cancer-associated fibroblasts
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MDPI and ACS Style

El-Daly, S.M.; Bayraktar, R.; Anfossi, S.; Calin, G.A. The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies. Int. J. Mol. Sci. 2020, 21, 3387. https://doi.org/10.3390/ijms21093387

AMA Style

El-Daly SM, Bayraktar R, Anfossi S, Calin GA. The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies. International Journal of Molecular Sciences. 2020; 21(9):3387. https://doi.org/10.3390/ijms21093387

Chicago/Turabian Style

El-Daly, Sherien M., Recep Bayraktar, Simone Anfossi, and George A. Calin. 2020. "The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies" International Journal of Molecular Sciences 21, no. 9: 3387. https://doi.org/10.3390/ijms21093387

APA Style

El-Daly, S. M., Bayraktar, R., Anfossi, S., & Calin, G. A. (2020). The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies. International Journal of Molecular Sciences, 21(9), 3387. https://doi.org/10.3390/ijms21093387

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