Special Issue "Biogenesis and Functional Roles of Lysosomes: Their Implications for the Pathogenesis and Therapy of Human Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2020).
Interests: autophagy; cell death; cathepsins; proteolysis; cancer; neurodegeneration; nutraceuticals; epigenetics
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The Lysosome is the most acidic compartment ubiquitously present in eukaryotic cells. Christian De Duve was awarded the Nobel Prize for having discovered this organelle in the early sixties. Since then, we have learned lots about the biogenesis and function of this organelle and of its related companions. Initially defined as a ‘suicide bag’ or ‘waste bin’, the lysosome has gained a noble reputation in recent decades as an organelle playing critical roles in cell death and survival and, by extension, in tissue homeostasis. The array of acidic hydrolases present in the lysosome endows this organelle with the ability to digest almost all the biomolecules delivered into it. Accordingly, the lack of a lysosomal enzyme would result in the abnormal accumulation of undigested substrate and a consequent lack of downstream products. Lysosome and lysosome-related organelles, which comprise early and late endosomes, constitute a dynamic network of vesicles that traffic and process substrates coming from inside and outside through the connection with the autophagy and endocytosis processes, respectively. In addition, the endosomal-lysosomal system is also involved in cell-to-cell communication through the exocytosis pathway and the release of exosomes, which are generated within the late endosomes. Specialized lysosome-related organelles are present in highly differentiated cells where these organelles accomplish unique functions. From the above, it appears clear that defective biogenesis or malfunctioning of this organelle would negatively impact human health. This Special Issue will collect either research or review articles addressing the biogenesis and pathophysiological role of lysosome and lysosome-related organelles in human health and disease.
Topics include, but are not limited to, the following:
- Biogenesis of acidic compartments and their function in cells;
- Trafficking of molecules and membranes among endosomal-lysosomal organelles;
- Endocytosis and exocytosis in cell communication;
- Biogenesis and function of exosomes;
- Lysosomes in cell survival and cell death pathways;
- Lysosomes and autophagy;
- Lysosomes in development and embryomorphogenesis;
- Dysfunctional lysosomes in human pathologies, with a special focus on autoimmune diseases, neurodegenerative diseases, lysosomal storage diseases, and cancer;
- Lysosomes as a therapeutic target in human diseases;
- Replacement gene therapy for lysosome dysfunction.
Prof. Dr. Ciro Isidoro
Manuscript Submission Information
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- cell homeostasis
- cell death
- lysosomal enzymes