Special Issue "Squamous Cell Cancer of the Head and Neck—Time to Arrive in the 21th Century of Oncology"
Deadline for manuscript submissions: 30 November 2020.
Interests: prostate cancer; lung cancer; head and neck cancer; molecular biology; molecular pathology; biomarker; immunoncology
Squamous cell carcinoma of the head and neck region (HNSCC) is the sixth most common cancer entity world-wide. However, despite achievements in other malignancies, the therapeutic options for HNSCC have still not been properly developed. Surgery or platin-based radiochemo therapy are incriminatory and often mutilating for patients. New therapeutic approaches such as immune check point inhibitors and kinase inhibitors do not have as much of an impact on HNSCC as on other tumor entities. This Issue focuses on deciphering the molecular basis of HNSCC in order to develop new alternative therapeutic options and biomarkers for early detection and risk stratification of primary and recurrent HNSCC. New therapeutic approaches are necessary, since the two-year survival of grade III and IV tumors is still only 30%. In particular, having reliable biomarkers to assess the risk for the clinically challenging existence of occult lymph node metastasis would be an important clinical tool to decide whether surgery or irradiation of the neck is necessary. The clinical follow-up of HNSCC patients is still based on clinical examination, ultrasound, and x-ray, while there is still no established biomarker for the detection of disease recurrence.
For this Issue, we would like to invite researchers and clinicians to submit their work in order to enlighten this heavily under researched field of HNSCC.
Prof. Dr. Sven Perner
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