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Molecules, Volume 27, Issue 1

January-1 2022 - 330 articles

Cover Story: In this work we have studied jumping spider rhodopsin-1 (JSR1), a bistable rhodopsin due to the fact that the retinal chromophore has several stable forms which can be interconverted by light. This makes JSR1 an ideal candidate for applications such as optogenetics. To study this system we performed hybrid QM/MM simulations with the 9-cis, 11-cis and all-trans configurations of the retinal chromophore. The chromophore–protein interactions were analyzed using the electrostatic potential of the protein. We found that the distance between a nearby tyrosine (Y126) residue and the retinal chromophore plays a larger role in the predicted absorption maximum of the three isomers than the primary counterion (E194). Furthermore, there are structural changes in the polyene chain of the chromophore and the nearby hydrogen-bonding network. View this paper.
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Articles (330)

  • Review
  • Open Access
155 Citations
31,617 Views
13 Pages

Glutathione in Brain Disorders and Aging

  • Igor Y. Iskusnykh,
  • Anastasia A. Zakharova and
  • Dhruba Pathak

5 January 2022

Glutathione is a remarkably functional molecule with diverse features, which include being an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in proteins, a stabilizer of cell membranes, and a detoxifier of xenobioti...

  • Article
  • Open Access
26 Citations
3,667 Views
14 Pages

5 January 2022

Raw Ca-based montmorillonite (MMT) was treated by H2SO4, calcination and organic compounds (hexadecyltrimethyl ammonium bromide (HTAB), cetylpyridinium chloride (CPC) and chitosan (CTS)), respectively. The modified montmorillonites were characterized...

  • Article
  • Open Access
26 Citations
4,839 Views
18 Pages

Synthesis of High Performance Thiophene–Aromatic Polyesters from Bio-Sourced Organic Acids and Polysaccharide-Derived Diol: Characterization and Degradability Studies

  • Lesly Dasilva Wandji Djouonkep,
  • Arnaud Kamdem Tamo,
  • Ingo Doench,
  • Naomie Beolle Songwe Selabi,
  • Emmanuel Monga Ilunga,
  • Arnaud Regis Kamgue Lenwoue,
  • Mario Gauthier,
  • Zhengzai Cheng and
  • Anayancy Osorio-Madrazo

5 January 2022

In this work, the feasibility of replacing petroleum-based poly(ethylene terephthalate) (PET) with fully bio-based copolyesters derived from dimethyl 2,5-thiophenedicarboxylate (DMTD), dimethyl 2,5-dimethoxyterephthalate (DMDMT), and polysaccharide-d...

  • Review
  • Open Access
14 Citations
4,541 Views
18 Pages

5 January 2022

Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulati...

  • Communication
  • Open Access
6 Citations
3,257 Views
9 Pages

The Caenorhabditis elegans DEG-3/DES-2 Channel Is a Betaine-Gated Receptor Insensitive to Monepantel

  • Tina V. A. Hansen,
  • Heinz Sager,
  • Céline E. Toutain,
  • Elise Courtot,
  • Cédric Neveu and
  • Claude L. Charvet

5 January 2022

Natural plant compounds, such as betaine, are described to have nematocidal properties. Betaine also acts as a neurotransmitter in the free-living model nematode Caenorhabditis elegans, where it is required for normal motility. Worm motility is media...

  • Article
  • Open Access
23 Citations
4,763 Views
12 Pages

Tunisian Native Mentha pulegium L. Extracts: Phytochemical Composition and Biological Activities

  • Jed Jebali,
  • Hanene Ghazghazi,
  • Chedia Aouadhi,
  • Ines ELBini-Dhouib,
  • Ridha Ben Salem,
  • Najet Srairi-Abid,
  • Naziha Marrakchi and
  • Ghayth Rigane

5 January 2022

Mint species (Lamiaceae family) have been used as traditional remedies for the treatment of several diseases. In this work, we aimed to characterize the biological activities of the total phenolic and flavonoid contents of Mentha pulegium L. extracts...

  • Article
  • Open Access
34 Citations
4,171 Views
17 Pages

5 January 2022

Common “glanded” (Gd) cottonseeds contain the toxic compound gossypol that restricts human consumption of the derived products. The “glandless” (Gl) cottonseeds of a new cotton variety, in contrast, show a trace gossypol conte...

  • Article
  • Open Access
20 Citations
3,288 Views
13 Pages

5 January 2022

Ultrasound treatment is recognized as a potential technique for improvement in the nutritional values of fruit juices. This study was initiated with the objective of evaluating bioactive compounds and some important quality parameters of black (BC),...

  • Article
  • Open Access
9 Citations
6,487 Views
21 Pages

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

  • Farhana Islam,
  • Arpit Doshi,
  • Andrew J. Robles,
  • Tasdique M. Quadery,
  • Xin Zhang,
  • Xilin Zhou,
  • Ernest Hamel,
  • Susan L. Mooberry and
  • Aleem Gangjee

5 January 2022

A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines were designed and synthesized and their biological activities were evaluated. Synthesis involved the Gewald reaction to synthesize ethyl 2-amino-4,5,6,7-tetrahydrob...

  • Article
  • Open Access
9 Citations
4,220 Views
15 Pages

Different Fruit-Specific Promoters Drive AtMYB12 Expression to Improve Phenylpropanoid Accumulation in Tomato

  • Xiangyu Ding,
  • Ziyi Yin,
  • Shaoli Wang,
  • Haoqi Liu,
  • Xiaomeng Chu,
  • Jiazong Liu,
  • Haipeng Zhao,
  • Xinyu Wang,
  • Yang Li and
  • Xinhua Ding

5 January 2022

Tomato is an economically crucial vegetable/fruit crop globally. Tomato is rich in nutrition and plays an essential role in a healthy human diet. Phenylpropanoid, a critical compound in tomatoes, reduces common degenerative and chronic diseases risk...

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Molecules - ISSN 1420-3049