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Special Issue "A Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Prof. Dr. Mauro Maccarrone
Guest Editor
1. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
2. European Center for Brain Research, Santa Lucia Foundation IRCCS, Rome, Italy
Interests: arachidonate cascade; bioactive lipids; biomarkers; cell membranes; endocannabinoids; resolvins; signal transduction
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

During the last 50 years, the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 years later, the molecular reasons for the biological activity of these plant extracts were made clearer by the discovery of endocannabinoids, which are endogenous lipids able to bind to the same cannabinoid receptors activated by THC. Besides endocannabinoids, which include several N-acylethanolamines and acylesters, a complex array of receptors, metabolic enzymes, transporters (transmembrane, intracellular, and extracellular carriers) were also discovered, and together they form a so-called “endocannabinoid system,” which has been shown to finely tune the manifold biological activities of these lipid signals.

Both plant-derived cannabinoids and endocannabinoids were first discovered by the group of Dr. Raphael Mechoulam, who has just celebrated his 90th birthday, and clearly stands out as a giant of modern science. The many implications of his seminal work for chemistry, biochemistry, biology, pharmacology, and medicine are described in this Special Issue by the scientists who in the past 20 years have reached the highest recognition in the field of (endo)cannabinoid research, receiving the Mechoulam Award for their major contributions. I thank them for having accepted my invitation to be part of this honorary issue of Molecules, and Raphi for continuing to illuminate our field with his always inspiring investigations and new ideas.

Prof. Dr. Mauro Maccarrone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cannabinoids
  • Drug Discovery
  • Endocannabinoids
  • Human Health
  • Lipid Biochemistry
  • Metabolism
  • Signal Tranduction
  • Therapeutics

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Mechoulam Award recipients, acting as confirmed contributors

Allyn Howlett           
Roger Pertwee         
George Kunos         
John Huffman         
Vincenzo Di Marzo   
Ken Mackie              
Patti Reggio           
Daniela Parolaro 
Cecilia Hillard
Ben Cravatt
Aron Lichtman
Beat Lutz
Mary Abood
Mauro Maccarrone
Andreas Zimmer
Natsuo Ueda      


Title: Potential therapeutic uses of certain cannabis-derived and synthetic cannabinoids revealed by their pharmacological properties
Authors: Roger G. Pertwee
Affiliation: University of Aberdeen, Scotland, UK

Title: Involvement of cPLA2 family members in N-acylethanolamine biosynthesis
Authors: Yiman Guo1,2; Toru Uyama1; S. M. Khaledur Rahman1,3; Mohammad Mamun Sikder1; Zahir Hussain1; Kazuhito Tsuboi4; Minoru Miyake2; Natsuo Ueda1
Affiliation: Departments of 1Biochemistry and 2Oral and Maxillofacial Surgery, Kagawa University School of Medicine, 1750-1, Ikenobe, Miki, Kagawa, 761-0793, Japan, 3Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore-7408, Bangladesh, and 4Department of Pharmacology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan

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