Neuropeptides: From Physiology to Therapeutic Applications

Dear Colleagues,

Neuropeptides are defined as small endogenous protein molecules that are synthesized and secreted by nerve cells generally through the regulated secretory route. Neuropeptides can act as neurohormones, neurotransmitters, neuromodulators, and neurotrophic or neuroprotective factors. Over one hundred neuropeptides have already been identified. They are involved in the control of a wide range of functions, including analgesia, reward, food intake, metabolism, reproduction, growth, stress response, sleep, social behaviors, learning, and memory. Many but not all neuropeptide receptors are members of the G protein-coupled receptor family, which represents one of the most important classes of drug targets. Therefore, a number of neuropeptides or neuropeptide-based compounds are in the pipeline of clinical trials for treatment of brain diseases, such as neurodegenerative pathologies, anxiety, pain, and other diseases like metabolic disorders, diabetes, and cancer. The scope of this Special Issue is to cover recent and promising research trends on neuropeptides. We welcome contributions—either original research or review articles—on fundamental and translational aspects of neuropeptides.

Prof. Dr. Jérôme Leprince
Prof. Dr. Hubert Vaudry
Prof. Dr. Billy KC Chow
Guest Editors