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Special Issue "Sustainable Chemistry in the Organic Synthesis of Bioactive Compounds"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 1 September 2021.

Special Issue Editors

Dr. Paola Costanzo
E-Mail Website
Guest Editor
Università degli Studi, Catanzaro, Italy
Interests: green chemistry; MW-assisted reactions; biorenewable feedstocks; organic-synthesis; green solvents
Prof. Dr. Antonio De Nino
E-Mail Website
Guest Editor
Dipartimento di Chimica, Università della Calabria Cubo 12C, 87036 Arcavacata di Rende CS, Italy
Interests: green chemistry; homogeneous catalysis; lanthanide Lewis acid catalysis; non-conventional reaction media; organic synthesis; asymmetric synthesis; composite material
Prof. Dr. Loredana Maiuolo
E-Mail Website
Guest Editor
Dipartimento di Chimica, Università della Calabria Cubo 12C, 87036 Arcavacata di Rende CS, Italy
Interests: green chemistry; homogeneous catalysis; lanthanide Lewis acid catalysis; nonconventional reaction media; organic synthesis; asymmetric synthesis; MW-assisted chemistry

Special Issue Information

Dear Colleagues,

Sustainable development is the new goal of modern society, for achieving “a healthy and productive life in harmony with Nature”. Chemistry plays a pivotal role in maintaining and improving our quality of life, the competitiveness of the chemical industry, and the natural environment. Starting from this, the twelve principles of green chemistry serve as excellent guidance when considering the environmental impact of any chemistry. Among them, the integration of green chemistry and engineering principles into the pharmaceutical industry is encouraged. With this aim, a wider pool of clean technologies could be customized for the synthesis of key molecules with biological activity. This Special Issue welcomes original research on the development of ecofriendly processes useful not only for organic synthesis but especially for medicinal chemistry. The scope is broad and includes (1) the use of renewable feedstocks, (2) the employment of alternative energy sources, (3) the use of non-toxic solvents, (4) catalysis, and (5) hazard reduction and waste minimization

Dr. Paola Costanzo
Prof. Dr. Antonio De Nino
Prof. Dr. Loredana Maiuolo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Green chemistry
  • Biomasses
  • Renewable sources
  • Atom economy
  • Alternative reaction media
  • Solvent-free reaction
  • Medicinal chemistry
  • Bioactive compounds.

Published Papers (1 paper)

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Research

Article
Structure–Activity Relationship Assessment of Sophorolipid Ester Derivatives against Model Bacteria Strains
Molecules 2021, 26(10), 3021; https://doi.org/10.3390/molecules26103021 - 19 May 2021
Viewed by 423
Abstract
Sophorolipids (SLs) are glycolipids that consist of a hydrophilic sophorose head group covalently linked to a hydrophobic fatty acid tail. They are produced by fermentation of non-pathogenic yeasts such as Candida Bombicola. The fermentation products predominantly consist of the diacetylated lactonic form [...] Read more.
Sophorolipids (SLs) are glycolipids that consist of a hydrophilic sophorose head group covalently linked to a hydrophobic fatty acid tail. They are produced by fermentation of non-pathogenic yeasts such as Candida Bombicola. The fermentation products predominantly consist of the diacetylated lactonic form that coexists with the open-chain acidic form. A systematic series of modified SLs were prepared by ring opening of natural lactonic SL with n-alkanols of varying chain length under alkaline conditions and lipase-selective acetylation of sophorose primary hydroxyl groups. The antimicrobial activity of modified SLs against Gram-positive human pathogens was a function of the n-alkanol length, as well as the degree of sophorose acetylation at the primary hydroxyl sites. Modified SLs were identified with promising antimicrobial activities against Gram-positive human pathogens with moderate selectivity (therapeutic index, TI = EC50/MICB. cereus = 6–33). SL-butyl ester exhibited the best antimicrobial activity (MIC = 12 μM) and selectivity (TI = 33) among all SLs tested. Kinetic studies revealed that SL-ester derivatives kill B. cereus in a time-dependent manner resulting in greater than a 3-log reduction in cell number within 1 h at 2×MIC. In contrast, lactonic SL required 3 h to achieve the same efficiency. Full article
(This article belongs to the Special Issue Sustainable Chemistry in the Organic Synthesis of Bioactive Compounds)
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