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Special Issue "Microbiocides Chemistry"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Prof. Bogumil E. Brycki

Laboratory of Microbiocides Chemistry, Umultowska 89 b, 61-614 Poznan, Poznan, Poland
Website | E-Mail
Interests: Organic Synthesis, Molecular Interactions, Surface Chemistry, Microbiocide Chemistry, Smart Materials, Corrosion Inhibition, Environmental Chemistry

Special Issue Information

Dear Colleagues,

Biocides are chemical substances for the control of organisms that are harmful to human or animal health or that cause damage to natural or manufactured products. Biocides are in the same class as herbicides, insecticides, rodenticides, molluscicides, and miticides. A special group of biocides are microbiocides, which are intended to reduce the population of microorganisms to a level that does not pose a threat, and includes antibacterials, antivirials, antifungals, as well as antiprotozoals and antialgae agents. Biocidal products usually consist of one or more active substances and some builders and conditioning agents, to regulate pH, viscosity, colour, etc. The products can be applied as water solutions, non-aqueous solutions, aerosols, or in a solid state. Microbiocides are used in medicine, pharmacy, the cosmetics industry, the veterinary, agricultural, and food industry, the paper industry, the textile industry, petrochemistry, the army, public places, consumer products, the protection of humanity’s heritage, and in many other instances.

The constantly increasing consumption of microbiocides poses risks to humans, animals, and the environment due to their toxic properties and associated use patterns.

Therefore, modern microbiocides should be characterized by biostatic and biocidal activity at the lowest possible concentrations against a wide variety of microorganisms. They should also have low toxicity and be safe to the ecosystem. Moreover, they should be able to be immobilized in natural polymers or inorganic carriers to form smart microbiocide materials that can be activated on demand only by physicochemical factors like pH, humidity, or temperature.

This Special Issue aims to review the latest synthetic or natural antimicrobial compounds that have been demonstrated to have good biocidal activity, low toxicity, efficient biodegradability, and the ability to prepare smart antimicrobial materials.

Prof. Bogumil E. Brycki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Novel synthetic microbiocides, structural determination, in-silico/ab-initio antimicrobial discovery
  • Microbiocides from terrestrial and marine organisms, essential oils, bioactive phytochemicals
  • Safety, toxicological, and ecotoxicological profiles of novel microbiocides
  • Biodegradability of microbiocides
  • Biofilm control and eradication
  • Biocorrosion inhibitors
  • Antibiodeterioration microbiocides
  • Microbiocides in non-aqueous solutions
  • Antimicrobial anti-adhesive surfaces and coatings
  • Smart microbiocide materials
  • Antimicrobials in consumer products (textiles, paper towels, hygienic papers, working liquids)
  • Active packaging in the food industry
  • Bioinformatics, comparative genomics, and molecular docking for the identification of antimicrobial targets
  • Regulatory issues

Published Papers (1 paper)

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Research

Open AccessArticle
Derivatization of Rosmarinic Acid Enhances its in vitro Antitumor, Antimicrobial and Antiprotozoal Properties
Molecules 2019, 24(6), 1078; https://doi.org/10.3390/molecules24061078
Received: 6 March 2019 / Revised: 14 March 2019 / Accepted: 16 March 2019 / Published: 19 March 2019
PDF Full-text (791 KB) | HTML Full-text | XML Full-text
Abstract
On its own, rosmarinic acid possesses multiple biological activities such as anti-inflammatory, antimicrobial, cardioprotective and antitumor properties, and these are the consequence of its ROS scavenging and inhibitory effect on inflammation. In this study, two quaternary phosphonium salts of rosmarinic acid were prepared [...] Read more.
On its own, rosmarinic acid possesses multiple biological activities such as anti-inflammatory, antimicrobial, cardioprotective and antitumor properties, and these are the consequence of its ROS scavenging and inhibitory effect on inflammation. In this study, two quaternary phosphonium salts of rosmarinic acid were prepared for the purpose of increasing its penetration into biological systems with the aim of improving its antimicrobial, antifungal, antiprotozoal and antitumor activity. The synthetized molecules, the triphenylphosphonium and tricyclohexylphosphonium salts of rosmarinic acid, exhibited significantly stronger inhibitory effects on the growth of HCT116 cells with IC50 values of 7.28 or 8.13 μM in comparison to the initial substance, rosmarinic acid (>300 μM). For the synthesized derivatives, we detected a greater than three-fold increase of activity against Acanthamoeba quina, and a greater than eight-fold increase of activity against A. lugdunensis in comparison to rosmarinic acid. Furthermore, we recorded significantly higher antimicrobial activity of the synthetized derivatives when compared to rosmarinic acid itself. Both synthetized quaternary phosphonium salts of rosmarinic acid appear to be promising antitumor and antimicrobial agents, as well as impressive molecules for further research. Full article
(This article belongs to the Special Issue Microbiocides Chemistry)
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