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Inhibitory Effects of Eriodictyol-7-O-β-d-glucuronide and 5,7-Dihydroxy-4-chromene Isolated from Chrysanthemum zawadskii var. latilobum in FcεRI-Mediated Human Basophilic KU812F Cell Activation

by Mina Lee 1 and Sun-Yup Shim 2,*
1
College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon-si, Jeonnam 57922, Korea
2
Department of Aqualife Science, College of Fisheries and Ocean Sciences, Chonnam National University, 50 Daehak-Ro, Yeosu, Jeonnam 59626, Korea
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(4), 994; https://doi.org/10.3390/molecules25040994
Received: 23 January 2020 / Revised: 17 February 2020 / Accepted: 20 February 2020 / Published: 23 February 2020
Chrysanthemum zawadskii var. latilobum (CZL) has been used in Eastern medicine for the treatment of various diseases, such as pneumonia, bronchitis, cough, the common cold, pharyngitis, bladder-related disorders, gastroenteric disorders, and hypertension. In the present study, we isolated two strong antiallergic compounds from CZL, namely, eriodictyol-7-O-β-d-glucuronide (EDG) and 5,7-dihydroxy-4-chromene (DC), and investigated their antiallergic effects in FcεRI-mediated human basophilic KU812F cells. EDG and DC downregulated the protein and messenger RNA (mRNA) expression of FcεRI on the cell surface. Moreover, Western blotting analysis showed that EDG and DC inhibited the expression of protein tyrosine kinases such as Syk and Lyn, and extracellular-regulated kinases (ERK) 1/2. These results suggested that EDG and DC, antiallergic constituents of CZL, are potential therapeutic candidates for protection against and for the treatment of allergic disorders. View Full-Text
Keywords: Chrysanthemum zawadskii var. latilobum; eriodictyol-7-O-β-d-glucuronide; 5,7-dihydroxy-4-chromene; FcεRI; histamine; extracellular regulated kinases 1/2 Chrysanthemum zawadskii var. latilobum; eriodictyol-7-O-β-d-glucuronide; 5,7-dihydroxy-4-chromene; FcεRI; histamine; extracellular regulated kinases 1/2
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Lee, M.; Shim, S.-Y. Inhibitory Effects of Eriodictyol-7-O-β-d-glucuronide and 5,7-Dihydroxy-4-chromene Isolated from Chrysanthemum zawadskii var. latilobum in FcεRI-Mediated Human Basophilic KU812F Cell Activation. Molecules 2020, 25, 994.

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