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Special Issue "Nitrilases and Nitrile Hydratases"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 October 2019

Special Issue Editors

Guest Editor
Prof. Dr. Ludmila Martínková

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
Website | E-Mail
Phone: +420 296 442 569
Interests: biocatalysis; bioremediation; protein overproduction; genome mining; enzymology; enzyme immobilization; nitrilases; nitrile hydratases; aldoxime hydratases; tyrosinases; nitrile metabolism in bacteria and fungi; biotransformation of nitriles; biotransformation of phenols
Co-Guest Editor
Dr. Margit Winkler

Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria
Website | E-Mail
Interests: biocatalysis; organic chemistry; protein overproduction; enzymology; nitrilases; nitrile hydratases; carboxylate reductases; hydroxynitrile lyases; CYP and non-CYP drug metabolizing enzymes; formation and biotransformation of nitriles; multistep reactions

Special Issue Information

Dear Colleagues,

The biotechnological impact of nitrilases and nitrile hydratases has become widely acknowledged since their discovery a few decades ago. The past 10 years or so have witnessed a tremendous increase in the number of the biochemically characterized enzymes of these types, but also in the number of sequences coding for their putative homologs. The long-lasting trend in the investigation of these enzymes is their improvement towards higher activities, selectivities, and stabilities, as well as exploring new resources of enzymes. Additionally, new biocatalytic uses are being constantly identified. All these approaches are necessary for a more intensive exploitation of the enzymes in the production of fine chemicals for the chemical, pharmaceutical, and food industries. This Special Issue will collect contributions on enhancing the biocatalytic potential of nitrilases and nitrile hydratases through, e.g., protein engineering, genome mining, metagenomic libraries screening, and new substrate and/or product identification.

We welcome submissions meeting the following criteria: (i) clear novelty; (ii) reproducibility; (iii) use of defined organisms and enzymes; (iv) focus on molecular aspects of the reactions. Papers which merely optimize known procedures or fail to clearly define the enzymes, substrates, and products will not be considered for publication. Publishing primary sequences of new enzymes is strongly encouraged.

Prof. Dr. Ludmila Martínková
Dr. Margit Winkler
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nitrilase
  • Nitrile hydratase
  • Genome mining
  • Metagenomic libraries
  • Protein engineering
  • Biocatalysis

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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