Special Issue "Nitrilases and Nitrile Hydratases"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 June 2020).
Interests: biotransformation, biocatalysis; gene expression; protein purification; immobilization; nitrilases; tyrosinases; laccases
Interests: biocatalysis; organic chemistry; protein overproduction; enzymology; nitrilases; nitrile hydratases; carboxylate reductases; hydroxynitrile lyases; CYP and non-CYP drug metabolizing enzymes; formation and biotransformation of nitriles; multistep reactions
The biotechnological impact of nitrilases and nitrile hydratases has become widely acknowledged since their discovery a few decades ago. The past 10 years or so have witnessed a tremendous increase in the number of the biochemically characterized enzymes of these types, but also in the number of sequences coding for their putative homologs. The long-lasting trend in the investigation of these enzymes is their improvement towards higher activities, selectivities, and stabilities, as well as exploring new resources of enzymes. Additionally, new biocatalytic uses are being constantly identified. All these approaches are necessary for a more intensive exploitation of the enzymes in the production of fine chemicals for the chemical, pharmaceutical, and food industries. This Special Issue will collect contributions on enhancing the biocatalytic potential of nitrilases and nitrile hydratases through, e.g., protein engineering, genome mining, metagenomic libraries screening, and new substrate and/or product identification.
We welcome submissions meeting the following criteria: (i) clear novelty; (ii) reproducibility; (iii) use of defined organisms and enzymes; (iv) focus on molecular aspects of the reactions. Papers which merely optimize known procedures or fail to clearly define the enzymes, substrates, and products will not be considered for publication. Publishing primary sequences of new enzymes is strongly encouraged.
Prof. Dr. Ludmila Martínková
Dr. Margit Winkler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Nitrile hydratase
- Genome mining
- Metagenomic libraries
- Protein engineering