Molecules, Volume 25, Issue 3 (February-1 2020) – 334 articles
Cover Story (view full-size image): Oligonucleotides, such as peptide nucleic acid (PNA), designed to block the synthesis of essential bacterial proteins, could be used as antibacterials. The limitation precluding PNA use is that bacterial cells do not uptake PNA. Thus, both PNA carriers and new targets in bacteria have been extensively searched for. The cover presents carriers of PNA to bacteria and possible targets for sequence-specific inhibition by PNA. The delivery strategies comprise covalent conjugation of PNA with cell-penetrating peptides (CPP) and with vitamin B12, as well as complementary base pairing between PNA and DNA to form a tetrahedral DNA nanostructure (TDN). PNA targets tested in Gram-negative bacteria include mRNA, ribosome (small 30S and large 50S subunit), and toxin–antitoxin (TA) systems. View this paper.
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