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Molecules, Volume 25, Issue 3 (February-1 2020) – 334 articles
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Cover Story (view full-size image) Since the discovery of the anticancer potential of ruthenium-based complexes, several species were [...] Read more. Since the discovery of the anticancer potential of ruthenium-based complexes, several species were reported as promising candidates for the treatment of breast cancer, which accounts for the greatest number of new cases in women every year worldwide. This review of the literature aims at providing an overview of the rationally designed ruthenium-based complexes that have been reported to date for which ligands were carefully selected for the treatment of hormone-receptor-positive breast cancers (estrogen receptor (ER+) or progesterone receptor (PR+)). In addition, this brief survey highlights some of the most successful examples of ruthenium complexes reported for the treatment of triple-negative breast cancer (TNBC), a highly aggressive type of cancer. View this paper.