Table of Contents
Molecules, Volume 25, Issue 12 (June-2 2020) – 235 articles
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Cover Story (view full-size image) Oxime ligation represents a form of post solid-phase diversification that is highly suited to [...] Read more. Oxime ligation represents a form of post solid-phase diversification that is highly suited to optimizing antagonists against therapeutically relevant protein–protein interactions (PPIs). Using as examples the tumor susceptibility gene 101 (Tsg101), protein tyrosine phosphatases (PTPases), and the polo-like kinase 1 (Plk1), we demonstrate how this technique provides a facile and empirical means of identifying protein–peptide interactions that may substantially increase binding affinities and selectivity. View this paper.