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28 Results Found

  • Article
  • Open Access
7 Citations
3,776 Views
24 Pages

Amoxicillin and sulbactam are widely used compound drugs in animal food. The amoxicillin–sulbactam hybrid molecule can achieve better curative effects through the combination of the two drugs. However, its pharmacokinetic behavior needs to be e...

  • Article
  • Open Access
25 Citations
5,086 Views
11 Pages

19 November 2019

An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of lactoferrin in camel milk based on the signature peptide. The camel lactoferrin was purified by heparin affinity chrom...

  • Article
  • Open Access
12 Citations
4,579 Views
12 Pages

Qualitative and Quantitative Analysis of the Major Constituents in WLJ Herbal Tea Using Multiple Chromatographic Techniques

  • Chao-Zhan Lin,
  • Run-Jing Zhang,
  • Yu-Feng Yao,
  • Xiao-Dan Huang,
  • Rong-Bo Zheng,
  • Bo-Jian Wu and
  • Chen-Chen Zhu

12 October 2018

Quality control of Chinese herbal tea remains a challenge due to our poor knowledge of their complex chemical profile. This study aims to investigate the chemical composition of one of the best-selling and famous brand of beverage in China, Wanglaoji...

  • Article
  • Open Access
33 Citations
7,690 Views
12 Pages

Morinda officinalis is an important herbal medicine and functional food, and its main constituents include anthraquinone and iridoid glycosides. Quantification of the main compounds is a necessary step to understand the quality and therapeutic proper...

  • Article
  • Open Access
23 Citations
3,394 Views
12 Pages

The Potential of Alternaria Toxins Production by A. alternata in Processing Tomatoes

  • Qiaomei Qin,
  • Yingying Fan,
  • Qinlan Jia,
  • Shuaishuai Duan,
  • Fengjuan Liu,
  • Binxin Jia,
  • Guangquan Wang,
  • Wanhui Guo and
  • Cheng Wang

24 November 2022

As a filamentous and spoilage fungus, Alternaria spp. can not only infect processing tomatoes, but also produce a variety of mycotoxins which harm the health of human beings. To explore the production of Alternaria toxins in processing tomatoes durin...

  • Article
  • Open Access
30 Citations
5,495 Views
20 Pages

Microbiological and Toxicological Hazards in Sewage Treatment Plant Bioaerosol and Dust

  • Justyna Szulc,
  • Małgorzata Okrasa,
  • Katarzyna Majchrzycka,
  • Michael Sulyok,
  • Adriana Nowak,
  • Tomasz Ruman,
  • Joanna Nizioł,
  • Bogumiła Szponar and
  • Beata Gutarowska

28 September 2021

Despite the awareness that work in the sewage treatment plant is associated with biological hazards, they have not been fully recognised so far. The research aims to comprehensively evaluate microbiological and toxicological hazards in the air and se...

  • Article
  • Open Access
15 Citations
6,789 Views
16 Pages

Ultrahigh Pressure Processing Produces Alterations in the Metabolite Profiles of Panax ginseng

  • Mee Youn Lee,
  • Digar Singh,
  • Sung Han Kim,
  • Sang Jun Lee and
  • Choong Hwan Lee

Ultrahigh pressure (UHP) treatments are non-thermal processing methods that have customarily been employed to enhance the quality and productivity of plant consumables. We aimed to evaluate the effects of UHP treatments on ginseng samples (white gins...

  • Article
  • Open Access
71 Citations
5,915 Views
16 Pages

17 January 2020

Dalbergia odorifera, a traditional Chinese medicine, has been used to treat cardio- and cerebrovascular diseases in China for thousands of years. Flavonoids are major active compounds in D. odorifera. In this paper, a rapid and sensitive ultra-high p...

  • Article
  • Open Access
5 Citations
2,826 Views
17 Pages

6-Oxofurostane and (iso)Spirostane Types of Saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-Molecular Networking Approach for the Rapid Dereplication and Biodistribution of Specialized Metabolites

  • Bharathi Avula,
  • Ji-Yeong Bae,
  • Jongmin Ahn,
  • Kumar Katragunta,
  • Yan-Hong Wang,
  • Mei Wang,
  • Yongsoo Kwon,
  • Ikhlas A. Khan and
  • Amar G. Chittiboyina

Identifying novel phytochemical secondary metabolites following classical pharmacognostic investigations is tedious and often involves repetitive chromatographic efforts. During the past decade, Ultra-High Performance Liquid Chromatography-Quadrupole...

  • Article
  • Open Access
8 Citations
8,507 Views
14 Pages

Comprehensive Quantitative Analysis of SQ Injection Using Multiple Chromatographic Technologies

  • Siu-Leung Chau,
  • Zhi-Bing Huang,
  • Yan-Gang Song,
  • Rui-Qi Yue,
  • Alan Ho,
  • Chao-Zhan Lin,
  • Wen-Hua Huang and
  • Quan-Bin Han

19 August 2016

Quality control of Chinese medicine injections remains a challenge due to our poor knowledge of their complex chemical profile. This study aims to investigate the chemical composition of one of the best-selling injections, Shenqi Fuzheng (SQ) injecti...

  • Article
  • Open Access
19 Citations
4,896 Views
12 Pages

Anti-Inflammatory Activity of Four Triterpenoids Isolated from Poriae Cutis

  • Lijia Zhang,
  • Mengzhou Yin,
  • Xi Feng,
  • Salam A. Ibrahim,
  • Ying Liu and
  • Wen Huang

20 December 2021

In this study, triterpenoid compounds from Poriae Cutis were separated by high-speed countercurrent chromatography (HSCCC) and identified using ultra-high performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTO...

  • Feature Paper
  • Article
  • Open Access
17 Citations
5,392 Views
16 Pages

18 October 2018

Proanthocyanidins are complex polymers of flavan-3-ol monomers and play a key sensory and health role in foods and beverages. We describe here a novel method for characterizing wine proanthocyanidins using a theoretical database comprised of the chem...

  • Article
  • Open Access
104 Citations
16,090 Views
15 Pages

Metabolomic Profiles of Aspergillus oryzae and Bacillus amyloliquefaciens During Rice Koji Fermentation

  • Da Eun Lee,
  • Sunmin Lee,
  • Eun Seok Jang,
  • Hye Won Shin,
  • Byoung Seok Moon and
  • Choong Hwan Lee

Rice koji, used early in the manufacturing process for many fermented foods, produces diverse metabolites and enzymes during fermentation. Using gas chromatography time-of-flight mass spectrometry (GC-TOF-MS), ultrahigh-performance liquid chromatogra...

  • Article
  • Open Access
35 Citations
4,606 Views
14 Pages

25 August 2018

Linarin, a flavone glycoside, is considered to be a promising natural product due to its diverse pharmacological activities, including analgesic, antipyretic, anti-inflammatory and hepatoprotective activities. In this research, the metabolites of lin...

  • Article
  • Open Access
2 Citations
1,332 Views
21 Pages

26 March 2025

Agrimonia pilosa Ledeb. (APL), a traditional Chinese herb frequently employed by Professor Zhou Zhongying, a master of traditional Chinese medicine, for colorectal cancer treatment, is rich in polyphenols with potential anti-tumor properties. To eluc...

  • Article
  • Open Access
7 Citations
3,401 Views
17 Pages

6 April 2022

Lotus seed epicarp, a byproduct of lotus, is commonly discarded directly or burned in the cropland, resulting in waste of resources and environmental pollution. In this work, a green ultrasonic-assisted extraction method with ethyl lactate as the ext...

  • Article
  • Open Access
31 Citations
51,876 Views
15 Pages

29 November 2018

Sinisan has been widely used to treat depression. However, its pharmacologically-effective constituents are largely unknown, and the pharmacological effects and clinical efficacies of Sinisan-containing processed medicinal herbs may change. To addres...

  • Proceeding Paper
  • Open Access
1 Citations
1,780 Views
6 Pages

Characterization of Functional Proteins from Edible Bird’s Nest Using Proteomic Techniques in Combination with Bioinformatics Analyses

  • Chia Hau Lee,
  • Norfadilah Hamdan,
  • Bemgba Bevan Nyakuma,
  • Haryati Jamaluddin,
  • Syie Luing Wong,
  • Keng Yinn Wong and
  • Ting Hun Lee

Edible bird’s nest (EBN) is a valuable and nutritious food tonic made from the saliva of swiftlet birds. EBN has been consumed for centuries due to its high nutritional value. Proteins are the main nutrient in EBN. However, studies investigatin...

  • Article
  • Open Access
9 Citations
2,624 Views
14 Pages

31 August 2022

Quinoa (Chenopodium quinoa Willd.) has a high nutritional value and it contains a high number and high amounts of specialized metabolites. These metabolites include, for example, phenolic acids, flavonoids, terpenoids and steroids. In addition, it is...

  • Article
  • Open Access
45 Citations
5,173 Views
20 Pages

15 January 2020

Ganpu tea is an emerging tea drink produced from Pu-erh tea and the pericarp of Citrus reticulate Chachi (GCP). Recently, it has been increasingly favored by consumers due to the potential health effects and special taste. However, information concer...

  • Article
  • Open Access
59 Citations
9,847 Views
27 Pages

Microwave-assisted extraction was applied to extract rutin; quercetin; genistein; kaempferol; and isorhamnetin from Flos Sophorae Immaturus. Six independent variables; namely; solvent type; particle size; extraction frequency; liquid-to-solid ratio;...

  • Article
  • Open Access
16 Citations
3,688 Views
19 Pages

Comprehensive Vitamer Profiling of Folate Mono- and Polyglutamates in Baker’s Yeast (Saccharomyces cerevisiae) as a Function of Different Sample Preparation Procedures

  • Lena Gmelch,
  • Daniela Wirtz,
  • Michael Witting,
  • Nadine Weber,
  • Lisa Striegel,
  • Philippe Schmitt-Kopplin and
  • Michael Rychlik

Folates are a group of B9 vitamins playing an important role in many metabolic processes such as methylation reactions, nucleotide synthesis or oxidation and reduction processes. However, humans are not able to synthesize folates de novo and thus rel...

  • Article
  • Open Access
124 Citations
15,200 Views
25 Pages

Accurate Dereplication of Bioactive Secondary Metabolites from Marine-Derived Fungi by UHPLC-DAD-QTOFMS and a MS/HRMS Library

  • Sara Kildgaard,
  • Maria Mansson,
  • Ina Dosen,
  • Andreas Klitgaard,
  • Jens C. Frisvad,
  • Thomas O. Larsen and
  • Kristian F. Nielsen

20 June 2014

In drug discovery, reliable and fast dereplication of known compounds is essential for identification of novel bioactive compounds. Here, we show an integrated approach using ultra-high performance liquid chromatography-diode array detection-quadr...

  • Article
  • Open Access
4 Citations
4,477 Views
19 Pages

Mining Small Molecules from Teredinibacter turnerae Strains Isolated from Philippine Teredinidae

  • Jamaine B. Villacorta,
  • Camille V. Rodriguez,
  • Jacquelyn E. Peran,
  • Jeremiah D. Batucan,
  • Gisela P. Concepcion,
  • Lilibeth A. Salvador-Reyes and
  • Hiyas A. Junio

21 November 2022

Endosymbiotic relationship has played a significant role in the evolution of marine species, allowing for the development of biochemical machinery for the synthesis of diverse metabolites. In this work, we explore the chemical space of exogenous comp...

  • Article
  • Open Access
20 Citations
3,349 Views
20 Pages

Dynamic Analysis of Physicochemical Properties and Polysaccharide Composition during the Pile-Fermentation of Post-Fermented Tea

  • Yan Luo,
  • Zhenjun Zhao,
  • Hujiang Chen,
  • Xueli Pan,
  • Risheng Li,
  • Dewen Wu,
  • Xianchun Hu,
  • Lingling Zhang,
  • Huawei Wu and
  • Xinghui Li

26 October 2022

Ultra-high performance liquid chromatography-quadrupole-time of flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) was used to study the diversity of tea polysaccharides and the dynamic changes in the physicochemical indexes of tea samples. FT-IR sp...

  • Article
  • Open Access
1,441 Views
25 Pages

26 September 2025

Background/Objectives: Allergic diseases (e.g., asthma, chronic urticaria) are increasing globally, but current anti-allergic drugs exhibit limitations in efficacy and safety. Traditional Chinese Medicine (TCM) emphasizes constitutional regulation fo...

  • Article
  • Open Access
1 Citations
2,168 Views
12 Pages

Influence of Citrus sunki and Poncirus trifoliata Root Extracts on Metabolome of Phytophthora parasitica

  • Héros José Maximo,
  • Francisca Diana da Silva Araújo,
  • Carolina Clepf Pagotto,
  • Leonardo Pires Boava,
  • Ronaldo José Durigan Dalio,
  • Gustavo Henrique Bueno Duarte,
  • Marcos Nogueira Eberlin and
  • Marcos Antonio Machado

Phytophthora parasitica is an oomycete pathogen that infects a broad range of crops of worldwide economic interest; among them are citrus species. In general, some Citrus and the rootstocks of related genera offer considerable resistance against P. p...

  • Article
  • Open Access
11 Citations
4,344 Views
16 Pages

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS

  • Yu-Feng Yao,
  • Chao-Zhan Lin,
  • Fang-Le Liu,
  • Run-Jing Zhang,
  • Qiu-Yu Zhang,
  • Tao Huang,
  • Yuan-Sheng Zou,
  • Mei-Qi Wang and
  • Chen-Chen Zhu

25 December 2018

The metabolic and pharmacokinetic studies on complanatuside, a quality marker of a Chinese materia medicatonic, Semen Astragali Complanati, were carried out. The UHPLC-Q-TOF/MS (ultra-high performance liquid chromatography coupled with electrospray i...