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19 Results Found

  • Article
  • Open Access
9 Citations
3,282 Views
11 Pages

26 November 2022

A novel clinical workflow utilizing a direction modulated brachytherapy (DMBT) tandem applicator in combination with a patient-specific, 3D printed vaginal needle-track template for an advanced image-guided adaptive interstitial brachytherapy of the...

  • Review
  • Open Access
74 Citations
12,305 Views
22 Pages

17 December 2010

Deleted in Malignant Brain Tumors-1 protein (DMBT1), salivary agglutinin (DMBT1SAG), and lung glycoprotein-340 (DMBT1GP340) are three names for glycoproteins encoded by the same DMBT1 gene. All these proteins belong to the scavenger receptor cysteine...

  • Article
  • Open Access
1 Citations
2,329 Views
14 Pages

Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study

  • Aleksandra Glapa-Nowak,
  • Mariusz Szczepanik,
  • Aleksandra Banaszkiewicz,
  • Barbara Iwańczak,
  • Jarosław Kwiecień,
  • Anna Szaflarska-Popławska,
  • Urszula Grzybowska-Chlebowczyk,
  • Marcin Osiecki,
  • Jarosław Kierkuś and
  • Marcin Banasiuk
  • + 3 authors

21 October 2021

Deleted in malignant brain tumours 1 protein (DMBT1) and surfactant protein D (SFTPD) are antimicrobial peptides previously linked to inflammatory bowel disease (IBD) susceptibility. This study attempts to link the most potential IBD-associated polym...

  • Review
  • Open Access
10 Citations
3,631 Views
12 Pages

12 November 2021

Human saliva is a complex body fluid with more than 3000 different identified proteins. Besides rheological and lubricating properties, saliva supports wound healing and acts as an antimicrobial barrier. TFF peptides are secreted from the mucous acin...

  • Article
  • Open Access
32 Citations
4,019 Views
10 Pages

Different Forms of TFF3 in the Human Saliva: Heterodimerization with IgG Fc Binding Protein (FCGBP)

  • Till Houben,
  • Sönke Harder,
  • Harmut Schlüter,
  • Hubert Kalbacher and
  • Werner Hoffmann

10 October 2019

The peptide TFF3 is a member of a family of secretory lectins, and is typically synthesized by mucous epithelia together with mucins. It is mainly released from intestinal goblet cells as a high-molecular mass heterodimer with IgG Fc binding protein...

  • Article
  • Open Access
6 Citations
3,031 Views
16 Pages

Pre-Treatment of Swine Oviductal Epithelial Cells with Progesterone Increases the Sperm Fertilizing Ability in an IVF Model

  • Costanza Cimini,
  • Fadl Moussa,
  • Angela Taraschi,
  • Marina Ramal-Sanchez,
  • Alessia Colosimo,
  • Giulia Capacchietti,
  • Samia Mokh,
  • Luca Valbonetti,
  • Israiel Tagaram and
  • Nicola Bernabò
  • + 1 author

6 May 2022

Mammalian spermatozoa are infertile immediately after ejaculation and need to undergo a functional modification, called capacitation, in order to acquire their fertilizing ability. Since oviductal epithelial cells (SOECs) and progesterone (P4) are tw...

  • Article
  • Open Access
8 Citations
3,386 Views
18 Pages

6 December 2022

The polypeptide TFF3 belongs to the trefoil factor family (TFF) of lectins. TFF3 is typically secreted from mucous epithelia together with mucins. Both intestinal and salivary TFF3 mainly exist as disulfide-linked heterodimers with IgG Fc binding pro...

  • Article
  • Open Access
21 Citations
8,357 Views
31 Pages

Associations between Circulating IGF-1 Concentrations, Disease Status and the Leukocyte Transcriptome in Early Lactation Dairy Cows

  • D. Claire Wathes,
  • Frank Becker,
  • Laura Buggiotti,
  • Mark A. Crowe,
  • Conrad Ferris,
  • Leslie Foldager,
  • Clément Grelet,
  • Miel Hostens,
  • Klaus L. Ingvartsen and
  • Cinzia Marchitelli
  • + 6 authors

25 November 2021

Peripartum dairy cows commonly experience negative energy balance (EB) and immunosuppression together with high incidences of infectious and metabolic disease. This study investigated mechanisms linking EB status with immune defense in early lactatio...

  • Article
  • Open Access
498 Views
14 Pages

31 October 2025

The performance of Multimodal Sentiment Analysis (MSA) is commonly hindered by two major bottlenecks: the complexity and redundancy associated with supervised feature disentanglement and the coarse granularity of static fusion mechanisms. To systemat...

  • Article
  • Open Access
1,483 Views
13 Pages

Electronically Coupled Heterojunctions Based on Graphene and Cu2−xS Nanocrystals: The Effect of the Surface Ligand

  • Ju Y. Shang,
  • Mariangela Giancaspro,
  • Adriana Grandolfo,
  • Rafique A. Lakho,
  • Elisabetta Fanizza,
  • Suraj K. Patel,
  • Giuseppe Valerio Bianco,
  • Marinella Striccoli,
  • Chiara Ingrosso and
  • Oscar Vazquez-Mena
  • + 1 author

27 December 2024

Optoelectronic devices combining single-layer graphene (SLG) and colloidal semiconducting nanocrystal (NC) heterojunctions have recently gained significant attention as efficient hybrid photodetectors. While most research has concentrated on systems...

  • Article
  • Open Access
8 Citations
4,255 Views
17 Pages

A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis

  • Carla Reale,
  • Filomena Russo,
  • Sara Carmela Credendino,
  • Danila Cuomo,
  • Gabriella De Vita,
  • Massimo Mallardo,
  • Francesca Pennino,
  • Immacolata Porreca,
  • Maria Triassi and
  • Mario De Felice
  • + 1 author

Epidemiological and experimental studies emphasize the link between environmental chemicals exposure and thyroid cancer. However, this association is strongly debated and the mechanisms of action of environmental thyroid carcinogens still need to be...

  • Article
  • Open Access
8 Citations
5,332 Views
13 Pages

Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients

  • Guangchun Han,
  • Ansam Sinjab,
  • Kieko Hara,
  • Warapen Treekitkarnmongkol,
  • Patrick Brennan,
  • Kyle Chang,
  • Elena Bogatenkova,
  • Beatriz Sanchez-Espiridion,
  • Carmen Behrens and
  • Luisa M. Solis
  • + 21 authors

12 March 2021

The novel coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Severely symptomatic COVID-19 is associated with lung inflammation, pneumonia, and respiratory failure, thereby raising concerns of elevated risk of COVID-19-associated...

  • Short Communication
  • Open Access
4 Citations
5,748 Views
9 Pages

Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice

  • Woon Yong Choi,
  • Ji Seon Kim,
  • Sung Jin Park,
  • Choong Je Ma and
  • Hyeon Yong Lee

8 April 2014

In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were...

  • Article
  • Open Access
1 Citations
1,872 Views
15 Pages

Genetic Analysis and Predictive Modeling of COVID-19 Severity in a Hospital-Based Patient Cohort

  • Iraide Alloza-Moral,
  • Ane Aldekoa-Etxabe,
  • Raquel Tulloch-Navarro,
  • Ainhoa Fiat-Arriola,
  • Carmen Mar,
  • Eloisa Urrechaga,
  • Cristina Ponga,
  • Isabel Artiga-Folch,
  • Naiara Garcia-Bediaga and
  • Patricia Aspichueta
  • + 8 authors

10 March 2025

The COVID-19 pandemic has had a devastating impact, with more than 7 million deaths worldwide. Advanced age and comorbidities partially explain severe cases of the disease, but genetic factors also play a significant role. Genome-wide association stu...

  • Article
  • Open Access
25 Citations
6,763 Views
29 Pages

Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic Inflammation

  • María Fernanda Suarez,
  • José Echenique,
  • Juan Manuel López,
  • Esteban Medina,
  • Mariano Irós,
  • Horacio M. Serra and
  • M. Elizabeth Fini

8 November 2021

Solar damage due to ultraviolet radiation (UVR) is implicated in the development of two proliferative lesions of the ocular surface: pterygium and pinguecula. Pterygium and pinguecula specimens were collected, along with adjacent healthy conjunctiva...

  • Article
  • Open Access
5 Citations
2,632 Views
11 Pages

Copy Number Variation Discovery in South African Nguni-Sired and Bonsmara-Sired Crossbred Cattle

  • Bhaveni B. Kooverjee,
  • Pranisha Soma,
  • Magrieta A. van der Nest,
  • Michiel M. Scholtz and
  • Frederick W. C. Neser

3 August 2023

Crossbreeding forms part of Climate-Smart beef production and is one of the strategies to mitigate the effects of climate change. Two Nguni-sired and three Bonsmara-sired crossbred animals underwent whole genome sequencing. Following quality control...

  • Article
  • Open Access
9 Citations
3,812 Views
21 Pages

Dietary Erythrodiol Modifies Hepatic Transcriptome in Mice in a Sex and Dose-Dependent Way

  • Roubi Abuobeid,
  • Luis Herrera-Marcos,
  • María A. Navarro,
  • Carmen Arnal,
  • Roberto Martínez-Beamonte,
  • Joaquín Surra and
  • Jesús Osada

4 October 2020

Erythrodiol is a terpenic compound found in a large number of plants. To test the hypotheses that its long-term administration may influence hepatic transcriptome and this could be influenced by the presence of APOA1-containing high-density lipoprote...

  • Case Report
  • Open Access
3 Citations
3,902 Views
12 Pages

Discovering Genotype Variants in an Infant with VACTERL through Clinical Exome Sequencing: A Support for Personalized Risk Assessment and Disease Prevention

  • Gloria Pelizzo,
  • Luigi Chiricosta,
  • Emanuela Mazzon,
  • Gian Vincenzo Zuccotti,
  • Maria Antonietta Avanzini,
  • Stefania Croce,
  • Mario Lima,
  • Placido Bramanti and
  • Valeria Calcaterra

5 January 2021

Congenital anomalies may have an increased risk of noncommunicable diseases (NCDs) We performed a clinical exome analysis in an infant affected by “Vertebral, Anorectal, Cardiac, Tracheoesophageal, Genitourinary, and Limb” (VACTERL) malfo...

  • Article
  • Open Access
19 Citations
4,192 Views
11 Pages

An MRI-Based Radiomic Prognostic Index Predicts Poor Outcome and Specific Genetic Alterations in Endometrial Cancer

  • Havjin Jacob,
  • Julie A. Dybvik,
  • Sigmund Ytre-Hauge,
  • Kristine E. Fasmer,
  • Erling A. Hoivik,
  • Jone Trovik,
  • Camilla Krakstad and
  • Ingfrid S. Haldorsen

2 February 2021

Integrative tumor characterization linking radiomic profiles to corresponding gene expression profiles has the potential to identify specific genetic alterations based on non-invasive radiomic profiling in cancer. The aim of this study was to develop...