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Open AccessShort Communication

Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice

1
Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, Korea
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Department of Tourism Food Service Cuisine, Hallym Polytechnic University, Gangwon 200-711, Korea
3
Department of Food Science and Technology, Seowon University, Cheongju, Chungbuk 361-742, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(4), 5907-5915; https://doi.org/10.3390/ijms15045907
Received: 16 December 2013 / Revised: 21 February 2014 / Accepted: 20 March 2014 / Published: 8 April 2014
(This article belongs to the Section Biochemistry)
In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceolata (FCL). Another 374 genes were up regulated and 527 genes down regulated without feeding the sample. The genes were not affected by the FCL sample. It was interesting that among those genes, Chytochrome P450, Dmbt1, LOC76487, and thyroid hormones, etc., were mostly up or down regulated. These genes are more related to lipid synthesis. We could conclude that the FCL possibly controlled the gene expression levels related to lipid synthesis, which resulted in reducing obesity. However, more detailed protein expression experiments should be carried out. View Full-Text
Keywords: fermented Codonopsis lanceolata; microarray; gene expression; obesity fermented Codonopsis lanceolata; microarray; gene expression; obesity
MDPI and ACS Style

Choi, W.Y.; Kim, J.S.; Park, S.J.; Ma, C.J.; Lee, H.Y. Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice. Int. J. Mol. Sci. 2014, 15, 5907-5915.

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