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31 Results Found

  • Article
  • Open Access
4 Citations
2,587 Views
18 Pages

Diversity of Cytauxzoon spp. (Piroplasmida: Theileriidae) in Wild Felids from Brazil and Argentina

  • Ana Cláudia Calchi,
  • Joares A. May-Júnior,
  • Vinícius Baggio-Souza,
  • Laura Berger,
  • Renata Fagundes-Moreira,
  • Rafaela Mallmann-Bohn,
  • Laíza de Queiroz Viana Braga,
  • Murillo Daparé Kirnew,
  • Matheus Folgearini Silveira and
  • Marcos Rogério André
  • + 9 authors

4 February 2025

Domestic and wild felids are frequently parasitized by apicomplexan protozoa in the genus Cytauxzoon. Expanding species diversity has recently been described within this genus, with potential implications for epidemiology and pathogenesis. In light o...

  • Article
  • Open Access
1,073 Views
13 Pages

First Detection of Cytauxzoon spp. DNA in Questing Ixodes ricinus Ticks

  • Marina L. Meli,
  • Theres Meili,
  • Benita Pineroli,
  • Eva Boenzli,
  • Ramon M. Eichenberger,
  • Barbara Willi and
  • Regina Hofmann-Lehmann

Feline cytauxzoonosis is an emerging tick-borne disease in Europe. While infections have been reported in different European countries, the tick vector remains unknown. This study investigated 665 ticks collected in 2019 (n = 160), 2022 (n = 7), and...

  • Case Report
  • Open Access
8 Citations
4,911 Views
13 Pages

Cytauxzoon sp. Infection and Coinfections in Three Domestic Cats in Central Italy

  • Maria Teresa Antognoni,
  • Francesca Rocconi,
  • Silvia Ravagnan,
  • Marta Vascellari,
  • Gioia Capelli,
  • Arianna Miglio and
  • Morena Di Tommaso

27 January 2022

Cytauxzoonosis is an emerging disease caused by a tick-transmitted haemoprotozoan affecting domestic and wild felids. The clinical and biomolecular findings of the infection due to Cytauxzoon sp. and concomitant coinfections are described in three ca...

  • Article
  • Open Access
28 Citations
4,091 Views
9 Pages

Cytauxzoon sp. and Hepatozoon spp. in Domestic Cats: A Preliminary Study in North-Eastern Italy

  • Marika Grillini,
  • Giulia Simonato,
  • Cinzia Tessarin,
  • Giorgia Dotto,
  • Donato Traversa,
  • Rudi Cassini,
  • Erica Marchiori and
  • Antonio Frangipane di Regalbono

18 September 2021

Knowledge on the presence of Cytauxzoon sp. and Hepatozoon spp. in Italy is scant and mostly limited to a few areas of Northern and Southern regions, respectively. The present study updated the current epidemiological scenario by investigating the oc...

  • Article
  • Open Access
2 Citations
3,090 Views
16 Pages

The Establishment of a Novel In Vitro System for Culturing Cytauxzoon felis

  • Pabasara Weerarathne,
  • Mason Reichard,
  • Craig Miller and
  • Ruth C. Scimeca

Cytauxzoonosis, a highly fatal tick-borne disease in domestic cats caused by Cytauxzoon felis, poses diagnostic and therapeutic challenges due to the inability to culture the parasite in vitro. This study aimed to artificially replicate C. felis infe...

  • Article
  • Open Access
10 Citations
5,745 Views
14 Pages

Prevalence of Cytauxzoon felis Infection-Carriers in Eastern Kansas Domestic Cats

  • Yvonne M. Wikander,
  • Tippawan Anantatat,
  • Qing Kang and
  • Kathryn E. Reif

20 October 2020

Cytauxzoon felis is a hemoprotozoal tick-transmitted pathogen of felids. Felids that survive acute disease often remain infected and serve as reservoirs for subsequent tick transmission to other susceptible felines. States adjacent to Kansas have ide...

  • Article
  • Open Access
5 Citations
6,221 Views
14 Pages

18 December 2020

Cytauxzoon felis, a tick-borne hemoprotozoal pathogen of felids, causes an acute, often-fatal disease in domestic cats. While public awareness of the disease has increased, few studies have evaluated the incidence of acute cytauxzoonosis cases and th...

  • Review
  • Open Access
19 Citations
11,495 Views
19 Pages

Cytauxzoon felis: An Overview

  • Yvonne M. Wikander and
  • Kathryn E. Reif

13 January 2023

Cytauxzoon felis is a tick-transmitted, obligate, hemoprotozoal, piroplasmid pathogen of felids and the causative agent of cytauxzoonosis. It has a complex life cycle which includes a tick as its definitive host and a felid as its intermediate host....

  • Article
  • Open Access
9 Citations
3,378 Views
15 Pages

The First Case of Cytauxzoon spp. in Russia: The Parasite Conquers Eurasia

  • Sergey V. Naidenko,
  • Mariya N. Erofeeva,
  • Pavel A. Sorokin,
  • Sergey O. Gershov,
  • Nadezhda P. Yakovenko,
  • Alena S. Botvinovskaya and
  • Galina S. Alekseeva

27 February 2022

Over the last two decades, Cytauxzoon spp. has been conquering Eurasia, although this fact has only been brought to light through recent more intensive research after the discovery of C. manul in Pallas’ cat. In Europe, Cytauxzoon was detected...

  • Editorial
  • Open Access
2 Citations
1,811 Views
3 Pages

Can Domestic Cats Act as Reservoirs of Cytauxzoon felis?

  • Adrian Alberto Díaz-Sánchez and
  • Alejandro Cabezas-Cruz

6 February 2023

Cytauxzoonosis is a worldwide tick-borne disease of domestic and wild felids, caused by infection of the haemoparasites belonging to the genus Cytauxzoon (Piroplasmida, Apicomplexa), which are apicomplexan protozoans closely related to those of the g...

  • Brief Report
  • Open Access
7 Citations
2,134 Views
8 Pages

Screening of Domestic Cats from North-Eastern Hungary for Hepatozoon felis and Cytauxzoon europaeus That Cause Infections in Local Wildcat Populations

  • Barbara Tuska-Szalay,
  • Sándor A. Boldogh,
  • Róbert Farkas,
  • Luca Rompos,
  • Nóra Takács,
  • Viktor Beresnyák,
  • Ádám Izsó,
  • Jenő Kontschán,
  • József Lanszki and
  • Sándor Hornok

Among vector-borne protozoa Hepatozoon felis and Cytauxzoon europaeus are considered emerging species in felids in Europe. To investigate the presence of these two protozoa 127 domestic cats and 4 wildcats were screened by PCRs targeting the 18S rRNA...

  • Article
  • Open Access
15 Citations
4,346 Views
17 Pages

Molecular Detection of Tick-Borne Agents in Cats from Southeastern and Northern Brazil

  • Marcos Rogério André,
  • Ana Cláudia Calchi,
  • Maria Eduarda Chiaradia Furquim,
  • Isabela de Andrade,
  • Paulo Vitor Cadina Arantes,
  • Lara Cristina de Melo Lopes,
  • Iuri Kauan Lins do Nascimento Demarchi,
  • Mayra Araguaia Pereira Figueiredo,
  • Cirilo Antonio de Paula Lima and
  • Rosangela Zacarias Machado

16 January 2022

Even though the epidemiology of tick-borne agents (TBA) in dogs has been extensively investigated around the world, the occurrence, vectors involved, and molecular identity of these agents in cats remains elusive in many regions. Among TBA, Ehrlichia...

  • Review
  • Open Access
18 Citations
7,813 Views
19 Pages

Cytauxzoonosis in North America

  • Mason V. Reichard,
  • Tiana L. Sanders,
  • Pabasara Weerarathne,
  • James H. Meinkoth,
  • Craig A. Miller,
  • Ruth C. Scimeca and
  • Consuelo Almazán

10 September 2021

Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids produced by infection of Cytauxzoon felis, an apicomplexan protozoan similar to Theileria spp. Transmitted by Amblyomma americanum, lone star tick, and Dermacentor variabili...

  • Article
  • Open Access
19 Citations
8,699 Views
21 Pages

Development of a Multiplex Droplet Digital PCR Assay for the Detection of Babesia, Bartonella, and Borrelia Species

  • Ricardo Maggi,
  • Edward B. Breitschwerdt,
  • Barbara Qurollo and
  • Jennifer C. Miller

11 November 2021

We describe the development, optimization, and validation of a multiplex droplet digital PCR (ddPCR) assay for the simultaneous detection of Babesia, Bartonella, and Borrelia spp. DNA from several sample matrices, including clinical blood samples fro...

  • Article
  • Open Access
2 Citations
4,523 Views
21 Pages

A Novel Vaccine Strategy to Prevent Cytauxzoonosis in Domestic Cats

  • Pabasara Weerarathne,
  • Rebekah Maker,
  • Chaoqun Huang,
  • Brianne Taylor,
  • Shannon R. Cowan,
  • Julia Hyatt,
  • Miruthula Tamil Selvan,
  • Shoroq Shatnawi,
  • Jennifer E. Thomas and
  • Craig A. Miller
  • + 4 authors

2 March 2023

Cytauxzoonosis is caused by Cytauxzoon felis (C. felis), a tick-borne parasite that causes severe disease in domestic cats in the United States. Currently, there is no vaccine to prevent this fatal disease, as traditional vaccine development strategi...

  • Article
  • Open Access
6 Citations
4,269 Views
14 Pages

N-Glycosylation in Piroplasmids: Diversity within Simplicity

  • Monica Florin-Christensen,
  • Anabel E. Rodriguez,
  • Carlos E. Suárez,
  • Massaro W. Ueti,
  • Fernando O. Delgado,
  • Ignacio Echaide and
  • Leonhard Schnittger

N-glycosylation has remained mostly unexplored in Piroplasmida, an order of tick-transmitted pathogens of veterinary and medical relevance. Analysis of 11 piroplasmid genomes revealed three distinct scenarios regarding N-glycosylation: Babesia sensu...

  • Article
  • Open Access
14 Citations
5,481 Views
12 Pages

Cysteine Proteinase C1A Paralog Profiles Correspond with Phylogenetic Lineages of Pathogenic Piroplasmids

  • Mariano E. Ascencio,
  • Monica Florin-Christensen,
  • Choukri B. Mamoun,
  • William Weir,
  • Brian Shiels and
  • Leonhard Schnittger

17 April 2018

Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition...

  • Article
  • Open Access
1 Citations
1,841 Views
19 Pages

Survey of Piroplasmids in Wild Mammals, Unconventional Pets, and Ticks from Goiás State, Midwestern Brazil

  • Raphaela Bueno Mendes Bittencourt,
  • Ana Cláudia Calchi,
  • Lucianne Cardoso Neves,
  • Nicolas Jalowitzki de Lima,
  • Gabriel Cândido dos Santos,
  • Ennya Rafaella Neves Cardoso,
  • Warley Vieira de Freitas Paula,
  • Luciana Batalha de Miranda Araújo,
  • Jessica Rocha Gonçalves and
  • Felipe da Silva Krawczak
  • + 4 authors

Tick-borne piroplasmids are apicomplexan protozoa that infect a wide range of vertebrate hosts, with significant implications for animal and human health. This study investigated the occurrence and genetic diversity of piroplasmids in wild mammals, u...

  • Article
  • Open Access
4 Citations
2,891 Views
15 Pages

A Serodiagnostic IgM ELISA to Detect Acute Cytauxzoonosis

  • Yun-Fan Kao,
  • Rebecca Spainhour,
  • Shannon R. Cowan,
  • Laura Nafe,
  • Adam Birkenheuer,
  • Mason V. Reichard and
  • Craig A. Miller

14 October 2022

Cytauxzoonosis is a tick-borne infectious disease affecting domestic cats with high mortality and limited treatment modalities. Because early diagnosis and therapeutic intervention are crucial to survival of infected cats, the objective of this study...

  • Article
  • Open Access
5 Citations
2,926 Views
12 Pages

Feline Vector-Borne Diseases and Their Possible Association with Hematological Abnormalities in Cats from Midwestern Brazil

  • Stephani Félix Carvalho,
  • Gracielle Teles Pádua,
  • Warley Vieira de Freitas Paula,
  • Mariana Avelar Tavares,
  • Lucianne Cardoso Neves,
  • Brenda Gomes Pereira,
  • Rayane Almeida Santos,
  • Gabriel Cândido dos Santos,
  • Ennya Rafaella Neves Cardoso and
  • Felipe da Silva Krawczak
  • + 4 authors

Among the parasitic and infectious diseases affecting cats, those caused by vector-borne pathogens deserve attention due to their ability to cause nonspecific clinical signs and clinicopathological abnormalities. We studied the presence of Cytauxzoon...

  • Article
  • Open Access
22 Citations
3,748 Views
16 Pages

Arthropod-Borne Pathogens in Stray Cats from Northern Italy: A Serological and Molecular Survey

  • Valentina Virginia Ebani,
  • Lisa Guardone,
  • Federica Marra,
  • Iolanda Altomonte,
  • Simona Nardoni and
  • Francesca Mancianti

8 December 2020

Cats may be affected by a wide range of arthropod-borne pathogens (ABPs) of medical and veterinary interest. Between February 2018 and October 2019, 85 blood samples were collected from stray cats from the Emilia Romagna region (northern Italy). Tick...

  • Article
  • Open Access
29 Citations
6,227 Views
16 Pages

Disease Surveillance during the Reintroduction of the Iberian Lynx (Lynx pardinus) in Southwestern Spain

  • Fernando Nájera,
  • Rebeca Grande-Gómez,
  • Jorge Peña,
  • Anastasio Vázquez,
  • María Jesús Palacios,
  • Carmen Rueda,
  • Ana Isabel Corona-Bravo,
  • Irene Zorrilla,
  • Luis Revuelta and
  • José Jiménez

19 February 2021

The restoration of Iberian lynx (Lynx pardinus) populations in Extremadura (Southwestern Spain) have been carried out since 2014. One of the measures to ensure the success of this program is to examine the effects that diseases may have on reintroduc...

  • Article
  • Open Access
5 Citations
3,550 Views
20 Pages

Parasitic Protozoa and Other Vector-Borne Pathogens in Captive Mammals from Brazil

  • Anisleidy Pérez Castillo,
  • Nicolas Colácio,
  • Pedro Henrique Cotrin Rodrigues,
  • João Victor Oliveira Miranda,
  • Paula Cristina Senra Lima,
  • Rafael Otávio Cançado Motta,
  • Herlandes Penha Tinoco,
  • Carlyle Mendes Coelho and
  • Júlia Angélica Gonçalves da Silveira

2 December 2024

In captive environments, mammals are frequently exposed to various parasitic protozoa and other vector-borne pathogens that can impact both animal health and public health. Monitoring these pathogens is essential for animal welfare and zoonotic disea...

  • Article
  • Open Access
5 Citations
2,437 Views
16 Pages

Piroplasm Infection in Domestic Cats in the Mountainous Region of Rio de Janeiro, Brazil

  • João Pedro Palmer,
  • Gilberto Gazêta,
  • Marcos André,
  • Aline Coelho,
  • Laís Corrêa,
  • José Damasceno,
  • Carolina Israel,
  • Rafael Pereira and
  • Alynne Barbosa

11 August 2022

Piroplasm infections in domestic cats have been reported with increasing frequency in numerous countries. However, in some states of Brazil, little information is available about the occurrence of these parasites. Blood samples were collected from 25...

  • Feature Paper
  • Article
  • Open Access
2 Citations
1,864 Views
16 Pages

12 July 2025

In Thailand, domestic cats are frequently exposed to vectors that transmit a variety of pathogens. In this study, the prevalence of vector-borne pathogens (VBPs) and their association with feline leukemia virus (FeLV) and feline immunodeficiency viru...

  • Article
  • Open Access
9 Citations
3,530 Views
15 Pages

Babesia microti Immunoreactive Rhoptry-Associated Protein-1 Paralogs Are Ancestral Members of the Piroplasmid-Confined RAP-1 Family

  • Reginaldo G. Bastos,
  • Jose Thekkiniath,
  • Choukri Ben Mamoun,
  • Lee Fuller,
  • Robert E. Molestina,
  • Monica Florin-Christensen,
  • Leonhard Schnittger,
  • Heba F. Alzan and
  • Carlos E. Suarez

26 October 2021

Babesia, Cytauxzoon and Theileria are tick-borne apicomplexan parasites of the order Piroplasmida, responsible for diseases in humans and animals. Members of the piroplasmid rhoptry-associated protein-1 (pRAP-1) family have a signature cysteine-rich...

  • Review
  • Open Access
48 Citations
11,291 Views
21 Pages

19 February 2021

Parasitic diseases caused by ticks constitute a barrier on global animal production, mainly in tropical and subtropical regions. As a country with a temperate and subtropical climate, Turkey has topography, climate, and pasture resources, and these r...

  • Article
  • Open Access
13 Citations
5,420 Views
19 Pages

Ticks and Tick-Borne Pathogens in Recreational Greenspaces in North Central Florida, USA

  • Chanakya R. Bhosale,
  • Kristen N. Wilson,
  • Kimberly J. Ledger,
  • Zoe S. White,
  • Rayann Dorleans,
  • Carrie E. De Jesus and
  • Samantha M. Wisely

Tick-borne infections are an increasing medical and veterinary concern in the southeastern United States, but there is limited understanding of how recreational greenspaces influence the hazard of pathogen transmission. This study aimed to estimate t...

  • Article
  • Open Access
29 Citations
5,026 Views
16 Pages

31 August 2021

Domestic felines’ re-emerging infectious and neglected zoonotic diseases are a significant focus of global “One Health” efforts. This study aimed to rapidly diagnose 14 pathogens, including zoonoses by using PCR primers in 167 client-owned symptomati...

  • Article
  • Open Access
2 Citations
1,789 Views
17 Pages

Using Digital PCR to Unravel the Occurrence of Piroplasmids, Bartonella spp., and Borrelia spp. in Wild Animals from Brazil

  • Ana Cláudia Calchi,
  • Anna Claudia Baumel Mongruel,
  • Fernanda Beatriz Pereira Cavalcanti,
  • Lilliane Bartone,
  • José Maurício Barbanti Duarte,
  • Emília Patrícia Medici,
  • Danilo Kluyber,
  • Mayara G. Caiaffa,
  • Mario Henrique Alves and
  • Marcos Rogério André
  • + 4 authors

Piroplasmids (Babesia spp., Rangelia spp., Theileria spp., Cytauxzoon spp.) are tick-borne apicomplexan protozoa that infect, depending on the species, erythrocytes and leucocytes in a wide variety of mammals and birds. The genera Bartonella and Borr...

  • Article
  • Open Access
7 Citations
2,569 Views
16 Pages

Development of Multiplex Assays for the Identification of Zoonotic Babesia Species

  • Ana Cláudia Calchi,
  • Charlotte O. Moore,
  • Lillianne Bartone,
  • Emily Kingston,
  • Marcos Rogério André,
  • Edward B. Breitschwerdt and
  • Ricardo G. Maggi

11 December 2024

More than one-hundred Babesia species that affect animals and humans have been described, eight of which have been associated with emerging and underdiagnosed zoonoses. Most diagnostic studies in humans have used serology or molecular assays based on...