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26 Results Found

  • Article
  • Open Access
1 Citations
1,517 Views
21 Pages

29 August 2024

Species delimitation of Culicoides complex species can be challenging. Among species within the Culicoides variipennis complex, C. sonorensis is considered the primary vector of bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHD...

  • Article
  • Open Access
12 Citations
4,641 Views
15 Pages

22 April 2019

Epizootic hemorrhagic disease virus (EHDV), an Orbivirus transmitted by Culicoides spp. vectors, is represented by seven serotypes and numerous strains worldwide. While studies comparing vector competence between serotypes exist, studies between vira...

  • Article
  • Open Access
12 Citations
3,390 Views
19 Pages

Exposure of Culicoides sonorensis to Enzootic Strains of Bluetongue Virus Demonstrates Temperature- and Virus-Specific Effects on Virogenesis

  • Jennifer Kopanke,
  • Justin Lee,
  • Mark Stenglein,
  • Molly Carpenter,
  • Lee W. Cohnstaedt,
  • William C. Wilson and
  • Christie Mayo

28 May 2021

Bluetongue virus (BTV) is a segmented RNA virus transmitted by Culicoides midges. Climatic factors, animal movement, vector species, and viral mutation and reassortment may all play a role in the occurrence of BTV outbreaks among susceptible ruminant...

  • Article
  • Open Access
18 Citations
5,873 Views
15 Pages

EHDV-2 Infection Prevalence Varies in Culicoides sonorensis after Feeding on Infected White-Tailed Deer over the Course of Viremia

  • Sandra Y. Mendiola,
  • Mary K. Mills,
  • Elin Maki,
  • Barbara S. Drolet,
  • William C. Wilson,
  • Roy Berghaus,
  • David E. Stallknecht,
  • Jonathan Breitenbach,
  • D. Scott McVey and
  • Mark G. Ruder

23 April 2019

Epizootic hemorrhagic disease viruses (EHDVs) are arboviral pathogens of white-tailed deer and other wild and domestic ruminants in North America. Transmitted by various species of Culicoides, EHDVs circulate wherever competent vectors and susceptibl...

  • Article
  • Open Access
22 Citations
8,909 Views
17 Pages

Venereal Transmission of Vesicular Stomatitis Virus by Culicoides sonorensis Midges

  • Paula Rozo-Lopez,
  • Berlin Londono-Renteria and
  • Barbara S. Drolet

Culicoides sonorensis biting midges are well-known agricultural pests and transmission vectors of arboviruses such as vesicular stomatitis virus (VSV). The epidemiology of VSV is complex and encompasses a broad range of vertebrate hosts, multiple rou...

  • Article
  • Open Access
45 Citations
5,957 Views
11 Pages

2 February 2021

Oropouche virus (OROV), a vector-borne Orthobunyavirus circulating in South and Central America, causes a febrile illness with high rates of morbidity but with no documented fatalities. Oropouche virus is transmitted by numerous vectors, including mu...

  • Article
  • Open Access
3 Citations
2,248 Views
13 Pages

Vesicular Stomatitis Virus Elicits Early Transcriptome Response in Culicoides sonorensis Cells

  • Stacey L. P. Scroggs,
  • Edward J. Bird,
  • David C. Molik and
  • Dana Nayduch

18 October 2023

Viruses that are transmitted by arthropods, or arboviruses, have evolved to successfully navigate both the invertebrate and vertebrate hosts, including their immune systems. Biting midges transmit several arboviruses including vesicular stomatitis vi...

  • Feature Paper
  • Article
  • Open Access
2,133 Views
15 Pages

microRNA Expression Dynamics in Culicoides sonorensis Biting Midges Following Blood-Feeding

  • Mary Katherine Mills,
  • Paula Rozo-Lopez,
  • William Bart Bryant and
  • Barbara S. Drolet

6 July 2023

Culicoides sonorensis midges vector multiple livestock arboviruses, resulting in significant economic losses worldwide. Due to the tight association between virus transmission, blood feeding, and egg development, understanding midge physiology is par...

  • Article
  • Open Access
7 Citations
2,481 Views
19 Pages

Evaluating Temperature Effects on Bluetongue Virus Serotype 10 and 17 Coinfection in Culicoides sonorensis

  • Molly Carpenter,
  • Jennifer Kopanke,
  • Justin Lee,
  • Case Rodgers,
  • Kirsten Reed,
  • Tyler J. Sherman,
  • Barbara Graham,
  • Lee W. Cohnstaedt,
  • William C. Wilson and
  • Christie Mayo
  • + 1 author

Bluetongue virus (BTV) is a segmented, double-stranded RNA virus transmitted by Culicoides midges that infects ruminants. As global temperatures increase and geographical ranges of midges expand, there is increased potential for BTV outbreaks from in...

  • Article
  • Open Access
7 Citations
3,556 Views
13 Pages

Comparison of Endemic and Epidemic Vesicular Stomatitis Virus Lineages in Culicoides sonorensis Midges

  • Paula Rozo-Lopez,
  • Steven J. Pauszek,
  • Lauro Velazquez-Salinas,
  • Luis L. Rodriguez,
  • Yoonseong Park and
  • Barbara S. Drolet

3 June 2022

Vesicular stomatitis virus (VSV) primarily infects livestock and is transmitted by direct contact and vectored by Culicoides midges (Diptera: Ceratopogonidae). Endemic to Central and South America, specific VSV lineages spread northward out of endemi...

  • Article
  • Open Access
1 Citations
2,930 Views
17 Pages

In Situ Hybridization (RNAscope) Detection of Bluetongue Virus Serotypes 10 and 17 in Experimentally Co-Infected Culicoides sonorensis

  • Molly Carpenter,
  • AnaMario Benavides Obon,
  • Jennifer Kopanke,
  • Justin Lee,
  • Kirsten Reed,
  • Tyler Sherman,
  • Case Rodgers,
  • Mark Stenglein,
  • Emily McDermott and
  • Christie Mayo

30 September 2023

Bluetongue virus (BTV) is a segmented, double-stranded RNA virus transmitted by Culicoides biting midges. Infection of domestic and wild ruminants with BTV can result in a devastating disease and significant economic losses. As a virus with a segment...

  • Article
  • Open Access
9 Citations
4,224 Views
15 Pages

9 April 2022

Culicoides midges play an important role in vesicular stomatitis virus (VSV) transmission to US livestock. After VSV-blood feeding, blood digestion followed by oviposition occurs while ingested virus particles replicate and disseminate to salivary gl...

  • Article
  • Open Access
13 Citations
4,079 Views
14 Pages

Culicoides sonorensis biting midges are biological vectors of vesicular stomatitis virus (VSV) in the U.S. Yet, little is known regarding the amount of ingested virus required to infect midges, nor how their feeding behavior or age affects viral repl...

  • Article
  • Open Access
1 Citations
1,997 Views
14 Pages

5 January 2024

Vesicular stomatitis virus (VSV) is an arthropod-borne virus affecting livestock. In the United States, sporadic outbreaks result in significant economic losses. During epizootics, Culicoides biting midges are biological vectors and key to the geogra...

  • Article
  • Open Access
10 Citations
3,848 Views
17 Pages

Identification of a BTV-Strain-Specific Single Gene That Increases Culicoides Vector Infection Rate

  • Honorata M. Ropiak,
  • Simon King,
  • Marc Guimerà Busquets,
  • Kerry Newbrook,
  • Gillian D. Pullinger,
  • Hannah Brown,
  • John Flannery,
  • Simon Gubbins,
  • Carrie Batten and
  • Karin E. Darpel
  • + 1 author

7 September 2021

Since the 2000s, the distribution of bluetongue virus (BTV) has changed, leading to numerous epidemics and economic losses in Europe. Previously, we found a BTV-4 field strain with a higher infection rate of a Culicoides vector than a BTV-1 field str...

  • Article
  • Open Access
6 Citations
4,667 Views
16 Pages

Transcriptome Response of Female Culicoides sonorensis Biting Midges (Diptera: Ceratopogonidae) to Early Infection with Epizootic Hemorrhagic Disease Virus (EHDV-2)

  • Dana Nayduch,
  • Vijay Shankar,
  • Mary K. Mills,
  • Tanner Robl,
  • Barbara S. Drolet,
  • Mark G. Ruder,
  • Erin D. Scully and
  • Christopher A. Saski

24 May 2019

Female Culicoides sonorensis biting midges are vectors of epizootic hemorrhagic disease virus (EHDV), which causes morbidity and mortality in wild and domesticated ruminants. The aims in this study were to identify key changes in female midge transcr...

  • Article
  • Open Access
8 Citations
8,387 Views
16 Pages

Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8

  • Eva Veronesi,
  • Karin Darpel,
  • Simon Gubbins,
  • Carrie Batten,
  • Kyriaki Nomikou,
  • Peter Mertens and
  • Simon Carpenter

Bluetongue virus (BTV) causes an economically important disease, bluetongue (BT), in susceptible ruminants and is transmitted primarily by species of Culicoides biting midges (Diptera: Ceratopogonidae). Since 2006, northern Europe has experienced mul...

  • Article
  • Open Access
15 Citations
4,211 Views
12 Pages

Detection of Vesicular Stomatitis Virus Indiana from Insects Collected during the 2020 Outbreak in Kansas, USA

  • Bethany L. McGregor,
  • Paula Rozo-Lopez,
  • Travis M. Davis and
  • Barbara S. Drolet

2 September 2021

Vesicular stomatitis (VS) is a reportable viral disease which affects horses, cattle, and pigs in the Americas. Outbreaks of vesicular stomatitis virus New Jersey serotype (VSV-NJ) in the United States typically occur on a 5–10-year cycle, usually af...

  • Article
  • Open Access
6 Citations
4,147 Views
12 Pages

3 August 2023

Culicoides biting midges (Diptera: Ceratopogonidae) are hematophagous flies that transmit several viruses of veterinary concern to livestock. Understanding blood feeding behaviors is integral towards identification of putative vector species and prev...

  • Review
  • Open Access
19 Citations
4,526 Views
20 Pages

Biting midges of the genus Culicoides occur almost globally and can regionally and seasonally reach high abundances. Most species are hematophagous, feeding on all groups of vertebrates, including humans. In addition to being nuisance pests, they are...

  • Article
  • Open Access
9 Citations
8,199 Views
14 Pages

Cytopathogenesis of Vesicular Stomatitis Virus Is Regulated by the PSAP Motif of M Protein in a Species-Dependent Manner

  • Takashi Irie,
  • Yuliang Liu,
  • Barbara S. Drolet,
  • Elena Carnero,
  • Adolfo García-Sastre and
  • Ronald N. Harty

19 September 2012

Vesicular stomatitis virus (VSV) is an important vector-borne pathogen of bovine and equine species, causing a reportable vesicular disease. The matrix (M) protein of VSV is multifunctional and plays a key role in cytopathogenesis, apoptosis, host pr...

  • Article
  • Open Access
5 Citations
3,111 Views
10 Pages

Using Zoos as Sentinels for Re-Emerging Arboviruses: Vector Surveillance during an Outbreak of Epizootic Hemorrhagic Disease at the Minnesota Zoo

  • Bethany L. McGregor,
  • Lindsey M. Reister-Hendricks,
  • Cale Nordmeyer,
  • Seth Stapleton,
  • Travis M. Davis and
  • Barbara S. Drolet

14 January 2023

Vector-borne disease prevalence is increasing at a time when surveillance capacity in the United States is decreasing. One way to address this surveillance deficiency is to utilize established infrastructure, such as zoological parks, to investigate...

  • Article
  • Open Access
3 Citations
1,931 Views
18 Pages

Assessing Reassortment between Bluetongue Virus Serotypes 10 and 17 at Different Coinfection Ratios in Culicoides sonorenesis

  • Molly Carpenter,
  • Jennifer Kopanke,
  • Justin Lee,
  • Case Rodgers,
  • Kirsten Reed,
  • Tyler J. Sherman,
  • Barbara Graham,
  • Mark Stenglein and
  • Christie Mayo

2 February 2024

Bluetongue virus (BTV) is a segmented, double-stranded RNA orbivirus listed by the World Organization for Animal Health and transmitted by Culicoides biting midges. Segmented viruses can reassort, which facilitates rapid and important genotypic chang...

  • Article
  • Open Access
20 Citations
3,945 Views
12 Pages

Vector Competence of Florida Culicoides insignis (Diptera: Ceratopogonidae) for Epizootic Hemorrhagic Disease Virus Serotype-2

  • Bethany L. McGregor,
  • Dinesh Erram,
  • Barry W. Alto,
  • John A. Lednicky,
  • Samantha M. Wisely and
  • Nathan D. Burkett-Cadena

5 March 2021

Epizootic hemorrhagic disease virus (EHDV; family Reoviridae, genus Orbivirus) is an arthropod-borne virus of ungulates, primarily white-tailed deer in North America. Culicoides sonorensis, the only confirmed North American vector of EHDV, is rarely...

  • Article
  • Open Access
1,746 Views
16 Pages

Increased Virulence of Culicoides Midge Cell-Derived Bluetongue Virus in IFNAR Mice

  • Barbara S. Drolet,
  • Lindsey Reister-Hendricks,
  • Christie Mayo,
  • Case Rodgers,
  • David C. Molik and
  • David Scott McVey

17 September 2024

Bluetongue (BT) is a Culicoides midge-borne hemorrhagic disease affecting cervids and ruminant livestock species, resulting in significant economic losses from animal production and trade restrictions. Experimental animal infections using the α...

  • Article
  • Open Access
12 Citations
3,926 Views
16 Pages

18 September 2020

Bluetongue virus (BTV) is an arbovirus that has been associated with dramatic epizootics in both wild and domestic ruminants in recent decades. As a segmented, double-stranded RNA virus, BTV can evolve via several mechanisms due to its genomic struct...