Immune Mechanisms Against Respiratory Viral Pathogens
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 30 December 2025 | Viewed by 2
Special Issue Editors
Interests: influenza; SARS-CoV and Bacterial pneumonia
Special Issues, Collections and Topics in MDPI journals
Interests: respiratory diseases and pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The respiratory system is constantly exposed to various viral pathogens, leading to severe lung infections, which can often cause life-threatening complications. Acute respiratory viral infections continue to pose a global threat, contributing to high morbidity and mortality in all age groups. An overwhelming immune response is one of the key contributors to acute lung injury in respiratory viral infections, often due to an exacerbated cytokine and chemokine response, the disruption of epithelial–endothelial barrier functions, and the excessive influx and dysregulation of innate immune cell mechanisms at the receptor level and in intracellular signaling.
This Special Issue will focus on the mechanisms behind immune response-related signaling in respiratory viral infections, crosstalk between innate and adaptive immunity in viral lung infections, and the role of cellular players (such as neutrophils, monocytes/macrophages, NK cells, dendritic cells, and T/B lymphocytes). Submissions describing research conducted at the cellular level, preclinical small- and large-animal models, and clinical trials will be accepted. The immune response signaling mechanisms that act against viral replication and growth include TLR (Toll-like receptor) signaling, interferon-related signaling, pro-inflammatory cytokine-mediated interference pathways, mechanisms involving RIG-I-like receptor signaling, and the NOD-like receptor protein 3 (NLRP3) inflammasome pathway. We invite submissions exploring the activation of these immune activation pathways and their downstream signaling, as well as early signaling events during virus infection, including pattern recognition receptors and immune signal transduction and mechanisms underlying pro-inflammatory cytokine generation. Further studies focusing on blockers, antagonists, or other therapeutic interventions targeting inflammatory signaling pathways are also welcome.
Dr. Telugu Akula Narasaraju
Dr. Sunil More
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- respiratory viral infections
- innate and adaptive immunity
- host–pathogen interactions
- inflammatory response
- therapeutic interventions
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