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Viruses
Special Issues
Porcine Viruses 2025
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Porcine Viruses 2025

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 129

Special Issue Editors

Prof. Dr. Guoxin Li

E-Mail Website
Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: development of vaccines against animal viruses
Special Issues, Collections and Topics in MDPI journals
Dr. Lingxue Yu

E-Mail Website
Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
Interests: viruses; immunology; vaccines
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jin Cui

E-Mail Website
Guest Editor
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
Interests: porcine virus; immune evasion; pathogenesis; epidemiology; virus evolution; prevention and control；vaccine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Swine virus disease is a kind of disease that inflicts great harm on the pig industry. It is not only harmful to pigs, but also highly contagious. Once a pig is infected, an entire farm or even an entire area is at risk. In recent years, various emerging and re-emerging disease pathogens have gradually broken through the existing immune defense line, through continuous recombination and evolution, resulting in the inefficiency or even ineffectiveness of current immune prevention and control measures, bringing significant threats and serious economic losses to the global pig industry. For example, African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), and porcine pseudorabies virus (PRV) constantly mutate under multiple selection pressures, such as body immunity and vaccine immunity. As the frequency of international trade increases, viruses spread faster and wider. Similar virus strains in different regions recombine with each other, making the recombinant mutant strains break through the existing immune prevention and control measures, increasing the difficulty of disease prevention and control. Therefore, this Special Issue will focus on the epidemiological study of swine viruses, the pathogenesis and immune escape mechanisms of the viruses, and the development of new vaccines in addition to other related disease prevention and control issues. We welcome you to provide relevant research articles, comments, and original research.

Prof. Dr. Guoxin Li
Dr. Lingxue Yu
Prof. Dr. Jin Cui
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epidemiology
  • pathogenesis
  • immune evasion
  • virus evolution
  • vaccine

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Published Papers (1 paper)

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Research

19 pages, 4600 KiB  
Article
The Junction Between nsp1β and nsp2 in the Porcine Reproductive and Respiratory Syndrome Virus Genome Is a New Site for the Insertion and Expression of Foreign Genes
by Changguang Xiao, Yafang Lin, Hailong Zhang, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Zhiyong Ma and Jianchao Wei
Viruses 2025, 17(5), 656; https://doi.org/10.3390/v17050656 (registering DOI) - 30 Apr 2025
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is considered a promising viral vector for the expression and delivery of foreign genes for the development of a new generation of multi-valent vaccines against PRRSV and other porcine viruses, as well as for analyses of [...] Read more.
Porcine reproductive and respiratory syndrome virus (PRRSV) is considered a promising viral vector for the expression and delivery of foreign genes for the development of a new generation of multi-valent vaccines against PRRSV and other porcine viruses, as well as for analyses of the immune response against PRRSV and anti-PRRSV component screening. In the present study, the junction site between nsp1β and nsp2 in the PRRSV genome was tested for the insertion and expression of foreign genes. Three foreign genes, including eGFP, iLOV3, and TEVp, were inserted into the intergenic junction between nsp1β and nsp2 and expressed by the respective recombinant PRRSVs (rPRRSV-SH01-eGFP, rPRRSV-SH01-iLOV3, and rPRRSV-SH01-TEVp) in vitro in mammalian cells. Analysis of the growth kinetics of the rescued recombinant PRRSVs showed no significant differences between the recombinant PRRSVs and their parental viruses. The inserted genes were consistently present in the viral genome during serial passage in vitro (for at least 20 passages). In addition, rPRRSV-SH01-eGFP can be used as a reporter virus for rapid detection of neutralizing antibodies against PRRSV through a fluorescent focus unit reduction-based assay. These data demonstrate that the junction between nsp1β and nsp2 is a new site that is suitable for the insertion and expression of foreign genes, providing a new option to express and deliver foreign genes using PRRSV-based vectors for different purposes, such as the development of multi-valent vaccines against PRRSV and other porcine viruses. Full article
(This article belongs to the Special Issue Porcine Viruses 2025)
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