Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: 2nd Edition
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 921
Special Issue Editor
Interests: eukaryotic translation mechanisms and their exploitation by viruses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Viruses depend on the translation apparatus of host cells for the synthesis of viral proteins. Infection is consequently influenced by competition between viral mechanisms that act to co-opt the cellular translation apparatus and cellular mechanisms that restrict viral access to it. Viral strategies include (a) synthesis of proteins that substitute for specific components of the translation apparatus, (b) modification of components of the host translation apparatus such as translation factors, ribosomes, or host mRNAs, thereby restricting cellular translation and the execution of cellular antiviral responses, and (c) exploitation of specialized elements in viral mRNAs to enable them to access the translation apparatus in these conditions. Viral infection imposes stresses on cells that activate signaling pathways and host innate immune defenses that may specifically silence translation of viral mRNAs or lead to a global shut-down of translation. Viruses have, in turn, evolved mechanisms to evade or subvert these host responses, thereby enabling viral translation to be maintained during infection.
This Special Issue will focus on recent advances in identifying viral effects on the cellular translation apparatus, in characterizing specialized viral translation mechanisms that function during infection, and in elucidating details of cellular mechanisms that restrict viral translation.
Dr. Christopher Hellen
Guest Editor
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Keywords
- virus–host interactions
- IRES elements
- RNA structure
- translation initiation
- translational control
- innate immune response
- RNA modification
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