Special Issues

Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chronic Infection by Oncogenic Viruses: 2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 122 | Submission Open
Keywords: virus transmission; virus replication; virus pathogenesis; virus latency; virus– host interactions; antiviral immune responses; virus-induced cellular transformation; antiviral drugs and vaccines
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Food-Associated and Foodborne Viruses: A Food Safety Concern or Tool?
edited by , Daofeng Liu and
submission deadline 28 Feb 2026 | Viewed by 121 | Submission Open
Keywords: foodborne viruses; norovirus epidemiology; viral zoonoses; phage biocontrol; food viromics; virus detection technologies
(This special issue belongs to the Section General Virology)
Viruses of Plant Pathogens and Pests
edited by Alexander V. Karasev
submission deadline 28 Feb 2026 | Viewed by 102 | Submission Open
Keywords: plant virus; virus diversity; transmission; genetic diversity; evolution; virus– host interactions
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Mpox (Monkeypox): From Neglected Tropical Disease to Emerging Global Pathogen
edited by , and Patrick Katoto
submission deadline 1 Mar 2026 | 16 articles | Viewed by 31428 | Submission Open
Keywords: monkeypox; mpox; monkeypox virus; mpxv; poxvirus; Poxviridae; Africa; DR Congo; outbreak; epidemic; stillbirth; sexual transmission; vaccination; emerging infection
(This special issue belongs to the Section Human Virology and Viral Diseases)
Spumaretroviruses: Research and Applications
edited by , , , Martin Löchelt and Paul Lesbats
submission deadline 1 Mar 2026 | 2 articles | Viewed by 2870 | Submission Open
Keywords: ancient retroviruses; antivirals; complex retroviruses; endogenous elements; foamy viruses; foamy virus-host interactions; foamy virus prevalence; foamy virus vectors; immune responses; molecular biology and replication; natural infections; nonhuman primates and non-primates; restriction factors spumaretroviruses; structural biology; taxonomy; viral proteins; virus detection assays; zoonoses
(This special issue belongs to the Section Animal Viruses)
Nucleocytoviricota
edited by Natalya Yutin
submission deadline 1 Mar 2026 | Viewed by 142 | Submission Open
Keywords: Nucleocytoviricota; giant viruses; virophages; host– virus (-virophage) interactions; virion structure; viral ecology; diversity and classification; evolution of Nucleocytoviricota Planned Paper  Title: Unveiling Intra-Clonal Diversity of Monkeypox Virus from Brazil’ s First Outbreak Wave Abstract: Orthopoxvirus monkeypox (MPXV) is an emerging zoonotic pathogen responsible for mpox; a disease characterized by smallpox-like symptoms; typically mild but occasionally fatal. The largest recorded global outbreak began in May 2022; with over 162; 000 cases across 140 countries (WHO; September 2025). Herein; we have analyzed a skin lesion sample from a male patient (June 2022); molecularly diagnosed as MPXV. The virus was isolated; purified; and characterized ultrastructurally; phenotypically; and genomically. In this study; three viral clones were obtained following phenotypic evaluation of MPXV lysis plaque characteristics over a three-course infection in BSC-40 cells. Unlike the vaccinia virus Western Reserve (VACV-WR) strain; MPXV clones did not form comet-like structures; suggesting reduced EEV particle release; which is associated with viral dissemination. Whole-genome sequencing and assembly identified subtle differences among clones. Comparative genomic analyses; including synteny and SNP calling; revealed intra-clonal differences and divergence from clade I and II references; although the variety of mutations found did not reveal possible variations at the protein level. Altogether; these findings provide novel insights into the MPXV replication cycle in vitro and the genomic characteristics of a strain isolated in Brazil during the early mpox outbreak. Keywords: Monkeypox virus; clone; phenotypic characterization; genome; SNPs; 2022 outbreak; MPOX
(This special issue belongs to the Section General Virology)
Epidemiology, Pathogenesis and Immunity of Adenovirus
edited by Adriana Kajon and
submission deadline 6 Mar 2026 | 6 articles | Viewed by 6461 | Submission Open
Keywords: human adenovirus; viral infection; pathogenesis; epidemiology; immune response; diagnosis; therapeutics; vaccine development
(This special issue belongs to the Section Human Virology and Viral Diseases)
Biotechnological Applications of Phage and Phage-Derived Proteins 2025
edited by
submission deadline 16 Mar 2026 | 3 articles | Viewed by 7194 | Submission Open
Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic
(This special issue belongs to the Section Bacterial Viruses)
Herpesviruses and Associated Diseases, 2nd Edition
edited by
submission deadline 20 Mar 2026 | Viewed by 100 | Submission Open
Keywords: human herpesviruses; animal herpesviruses; viral latency and reactivation; immune evasion strategies; herpesvirus– host interactions; herpesvirus biology and pathogenesis; herpesvirus diagnosis; environmental factors; herpesvirus-associated diseases; prevention and treatment strategies; antiviral therapies; vaccine development
(This special issue belongs to the Section Human Virology and Viral Diseases)
Coronaviruses and Influenza Viruses: Evolution, Cross-Species Transmission, and Recombination
edited by
submission deadline 31 Mar 2026 | 5 articles | Viewed by 10797 | Submission Open
Keywords: coronaviruses; influenza viruses; highly pathogenic influenza viruses; species jump; avian coronaviruses; porcine coronaviruses; vaccines; diagnostic assays; one health; virus/host interaction.
(This special issue belongs to the Section Coronaviruses)
Host-Mediated Viral Mutations: APOBECs, ADARs, and Beyond
edited by
submission deadline 31 Mar 2026 | 4 articles | Viewed by 7128 | Submission Open
Keywords: cytosine and adenosine deamination; methylcytosine; epigenetics; mutagenesis; cancer; APOBEC antagonists; ADAR; DNA damage response; innate immunity; adaptive immunity; virus selection
(This special issue belongs to the Section Human Virology and Viral Diseases)
Hepatitis Viral Infections, Pathogenesis and Therapeutics (2nd Edition)
edited by
submission deadline 31 Mar 2026 | 3 articles | Viewed by 6532 | Submission Open
Keywords: hepatitis A virus (HAV); hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis D virus (HDV); hepatitis E virus (HEV); chronic liver disease; chronic hepatitis; liver cirrhosis; hepatocellular carcinoma (HCC); liver cancer; antiviral therapy
(This special issue belongs to the Section Human Virology and Viral Diseases)
Cascade of Care for HIV, Hepatitis and Sexually Transmitted Infections submission deadline 31 Mar 2026 | 6 articles | Viewed by 6074 | Submission Open
Keywords: HIV; AIDS; cascade; linkage; HCV; HBV; sexually transmitted infections
(This special issue belongs to the Section Human Virology and Viral Diseases)
Interferon Signaling in Viral Pathogenesis
edited by Lishan Su
submission deadline 31 Mar 2026 | 4 articles | Viewed by 5686 | Submission Open
Keywords: type I  interferons; virus replication; viral pathogenesis; autoimmune diseases; inflamation-induced cancer; immunotherapy
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Animal Herpesvirus 2025
edited by
submission deadline 31 Mar 2026 | 4 articles | Viewed by 4610 | Submission Open
Keywords: herpesviruses; innate immune responses; host adaptive immune responses; herpesvirus-host; interactions; susceptibility
(This special issue belongs to the Section Animal Viruses)
Herpesvirus Transcriptional Control
edited by
submission deadline 31 Mar 2026 | 3 articles | Viewed by 3710 | Submission Open
Keywords: herpes simplex virus; herpesvirus gene expression; viral latency and reactivation; virus– host interactions
(This special issue belongs to the Section Animal Viruses)
Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry
edited by
submission deadline 31 Mar 2026 | 3 articles | Viewed by 2841 | Submission Open
Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms
(This special issue belongs to the Section Animal Viruses)
HPV-Associated Cancers 2025
edited by Diane M. Harper
submission deadline 31 Mar 2026 | 1 articles | Viewed by 2782 | Submission Open
Keywords: HPV; cervical cancer; head and neck cancer; penile cancer; cancer prevention; targeted therapy; cancer stem cells; molecular study; carcinogenesis; immunotherapy
(This special issue belongs to the Section Human Virology and Viral Diseases)
Advancements in Immunotherapy for Human Papillomavirus
edited by Katharine A. Price
submission deadline 31 Mar 2026 | 1 articles | Viewed by 2736 | Submission Open
Keywords: human papillomavirus; cancer screening; vaccination; treatment; head-and-neck cancer; oropharyngeal cancer
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Tick-Borne Viruses 2026
edited by
submission deadline 31 Mar 2026 | 3 articles | Viewed by 2543 | Submission Open
Keywords: tick-borne viruses; vector-borne pathogens; virus– tick– host interactions; saliva-assisted transmission; tick exosomes; tick antiviral mechanisms; virus evolution; surveillance
(This special issue belongs to the Section General Virology)
Development of Diagnostics and Therapeutic Interventions for Viral Infections of the Central Nervous System
edited by Karin E. Peterson and Amanda E. Calvert
submission deadline 31 Mar 2026 | 1 articles | Viewed by 2146 | Submission Open
Keywords: encephalitis; arbovirus; diagnosis; treatment; neurovirology; antibody therapeutics; agnostic therapeutics; point of care diagnostics; rapid diagnostics
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Advances in HSV
edited by Susmit Suvas and James Chodosh
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1888 | Submission Open
Keywords: HSV-1; HSV-2; latency; herpes epithelial keratitis; herpes stromal keratitis; HSV vaccine; herpes simplex encephalitis
(This special issue belongs to the Section Human Virology and Viral Diseases)
Regulation of HIV-1 Transcription and Latency, 2nd Edition
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1594 | Submission Open
Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir
(This special issue belongs to the Section Human Virology and Viral Diseases)
Dengue, Zika and Yellow Fever Virus Replication
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1548 | Submission Open
Keywords: flavivirus; dengue; Zika; yellow fever; virus replication; virus entry; genome replication; host cell factors; replication structures
(This special issue belongs to the Section Invertebrate Viruses)
HIV and Viral Hepatitis Co-Infection submission deadline 31 Mar 2026 | 1 articles | Viewed by 1353 | Submission Open
Keywords: HIV; hepatitis A; hepatitis B; hepatitis C; hepatitis delta; hepatitis E; co-infection; antiviral therapy
(This special issue belongs to the Section Human Virology and Viral Diseases)
Novel Insights into Porcine Viral Diseases: Recombinant Strains and Immune Responses
edited by and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1326 | Submission Open
Keywords: porcine viral diseases; epidemiology; pathogenesis; recombination; immune responses
(This special issue belongs to the Section Animal Viruses)
Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1301 | Submission Open
Keywords: medicinal chemistry of anti-HCV; anti-HBV and anti-flavivirus agents; synthesis; structure activity relationships (SAR); antiviral drug discovery; HBV; HCV; Dengue (DENV); Yellow Fever (YFV); West Nile (WNV); Zika (ZIKV); mechanism of action; drug targets; in silico studies
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
HIV and Aging
edited by Eugenia Negredo
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1044 | Submission Open
Keywords: HIV and aging; accelerated and accentuated aging; immune senescence; inflammation; comorbidities; geriatric syndromes; neurocognitive function; functional status; antiretroviral therapy
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Virus Bioinformatics 2025
edited by and
submission deadline 31 Mar 2026 | Viewed by 925 | Submission Open
Keywords: virus bioinformatics; software; viral metagenomics and ecology; virus– host interactions; viral diversity and evolution; virus identification
(This special issue belongs to the Section General Virology)
Bacteriophages and Biofilms 2026 submission deadline 31 Mar 2026 | 1 articles | Viewed by 765 | Submission Open
Keywords: bacteriophages; phage therapy; biofilms; phage– biofilm interaction; depolymerases; antibiofilm agents; phage engineering; phage resistance; combination therapy; microbial ecology
(This special issue belongs to the Section Bacterial Viruses)
Epidemiology, Risk Analysis, Detection and Management of Lumpy Skin Disease in Europe
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 749 | Submission Open
Keywords: lumpy skin disease (LSD); lumpy skin disease virus (LSDV); vectors; pathogenesis; epidemiology; modelling; risk analysis; detection; management; cost– benefit analysis; Europe
(This special issue belongs to the Section Animal Viruses)
Lytic Cycle of Herpesviruses and the Associated Pathogenesis
edited by Junjie Zhang, and Tingting Li
submission deadline 31 Mar 2026 | Viewed by 509 | Submission Open
Keywords: herpesviruses; innate immune responses; life cycle; herpesvirus– host interactions; pathogenesis
(This special issue belongs to the Section Human Virology and Viral Diseases)
Advances in Plant Virus/Viroid Detection and Identification Methods, 2nd Edition
edited by Laura Tomassoli and
submission deadline 31 Mar 2026 | Viewed by 267 | Submission Open
Keywords: plant viruses and viroids diagnostics; high-throughput sequencing; bioinformatics; virus taxonomy; virus/viroid– plant– vector interactions; real-time PCR; digital droplet PCR; hyperspectral imaging; machine learning; artificial intelligence; biosensors
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Viral Non-Structural Proteins
edited by
submission deadline 31 Mar 2026 | Viewed by 261 | Submission Open
Keywords: viral genome; non-structural proteins; virus replication; vaccines; viral therapeutics
(This special issue belongs to the Section General Virology)
New Findings in Animal Biosecurity Related to Viral Diseases
edited by and Jean-Pierre Vaillancourt
submission deadline 31 Mar 2026 | Viewed by 253 | Submission Open
Keywords: viruses; animal; biosecurity; evaluation; communication; needs; cost– benefit analysis; behaviour change
(This special issue belongs to the Section Animal Viruses)
Chikungunya Virus in Viral Immunology and Vaccine Research
edited by Shuaiyao Lu and
submission deadline 31 Mar 2026 | Viewed by 214 | Submission Open
Keywords: Chikungunya virus; viral immunology; CHIKV vaccine development; virus– host interactions; innate immunity; adaptive immunity; neutralizing antibodies; viral pathogenesis; vaccine platforms; antivirals; Alpha virus
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Rabies Virus: Treatment and Prevention—2nd Edition submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open
Keywords: rabies; antiviral; treatment; prevention
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—a Persistent Threat to Public and Animal Health
edited by
submission deadline 31 Mar 2026 | Viewed by 134 | Submission Open
Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host
(This special issue belongs to the Section General Virology)
Antiviral Protease Inhibitors
edited by Xufang Deng and
submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open
Keywords: antiviral drug discovery; high-throughput screen; structure-guided drug design; artificial intelligence (AI)-based drug discovery; drug resistance; combination therapies; antiviral assay development; host-targeting antiviral
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Immune Evasion and Viral Carcinogenesis
edited by and Tuan L. Phan
submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open
Keywords: viral oncogenesis; viral carcinogenesis; immune evasion; immune surveillance; oncogenic viruses; immunosuppression; host-pathogen interactions
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
SARS-CoV-2 in Pregnancy and Reproduction, 2nd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 91 | Submission Open
Keywords: COVID-19; SARS-CoV-2; coronavirus; pregnancy; reproduction; vaccination; mutagenesis
(This special issue belongs to the Section Coronaviruses)
Polyomavirus
edited by and Patrick S. Moore
submission deadline 1 Apr 2026 | Viewed by 115 | Submission Open
Keywords: virus– host interactions; viral life cycle; viral replication; pathogenesis; phylogeny; structure; transcription; packaging; trafficking; persistence; re-arrangements; gene regulation; reactivation; miRNA; viral immune evasion; vaccines
(This special issue belongs to the Section Animal Viruses)
Human Leukocyte Antigen (HLA) in Viral Infections
edited by Nicholas Borcherding
submission deadline 5 Apr 2026 | Viewed by 401 | Submission Open
Keywords: HLA; viral infection; immune response; T cells; antigen presentation; viral evasion; immunogenetics; polymorphism; disease susceptibility; vaccine development
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Beyond Acute: Navigating Long COVID and Post-Viral Complications
edited by Maggie Bartlett, Janko Nikolich-Žugich, Rubeshan Perumal and Anders Vahlne
submission deadline 15 Apr 2026 | 4 articles | Viewed by 8402 | Submission Open
Keywords: long COVID; post-viral complications; dysregulated immune responses; neurological complications; respiratory complications; cardiovascular complications; pregnancy-related complications
(This special issue belongs to the Section Human Virology and Viral Diseases)
Broadly Protective Anti-Viral Vaccines 2025
edited by
submission deadline 15 Apr 2026 | 1 articles | Viewed by 2469 | Submission Open
Keywords: universal vaccines; structure-based rational design; cross-protection; broadly neutralizing antibody; T-cell epitopes; preventative and therapeutic vaccines; adaptive immunology; highly variable virus
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Swine Viruses: Immunology and Vaccinology
edited by and
submission deadline 15 Apr 2026 | 1 articles | Viewed by 1560 | Submission Open
Keywords: swine virology; swine immunology; vaccine development; vaccinology; viral pathogenesis; vaccine design; disease prevention; swine health
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Cross-Pathogen Insights into Infectious Diseases: From Biomarkers to Burden and Therapeutic Strategies of Viral Pathogens submission deadline 15 Apr 2026 | 1 articles | Viewed by 262 | Submission Open
Keywords: cross-pathogen perspective; biomarkers; viral sepsis; therapeutic landscape
(This special issue belongs to the Section General Virology)
Mechanisms of Ribozyviria Transmission in Animal and Vegetal Holobionts
edited by and Ferruccio Bonino
submission deadline 15 Apr 2026 | Viewed by 220 | Submission Open
Keywords: viroid-like RNAs; holobionts; RNA viruses; circular RNA genomes; satellite viruses; HBsAg (hepatitis b surface antigen)
(This special issue belongs to the Section General Virology)
Viral Infections in Hematopoietic Stem Cell Transplant and Cellular Therapy Recipients, 2nd Edition
edited by Sanjeet Singh Dadwal
submission deadline 15 Apr 2026 | Viewed by 159 | Submission Open
Keywords: HSCT; GVHD; HHV6; CMV; adenovirus; BK and JC virus (polyomaviruses); HIV
(This special issue belongs to the Section Human Virology and Viral Diseases)
HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7140 | Submission Open
Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities
(This special issue belongs to the Section Human Virology and Viral Diseases)
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