Novel Insights into Porcine Viral Diseases: Recombinant Strains and Immune Responses

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 490

Special Issue Editors


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Guest Editor
College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China
Interests: veterinary vaccines; veterinary diagnostics; veterinary immunity
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: veterinary viruses; pathogenesis; vaccine and diagnostics; swine viral diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Porcine viral diseases have posed a huge economic loss to the swine industry in China. Many important porcine viral pathogens, including African Swine Fever Virus (ASFV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), and Porcine Epidemic Diarrhea Virus (PEDV), have undergone genetic variations to escape host immunity.

The aim of this Special Issue is to offer a dedicated opportunity for collecting the newest contributions in the field of porcine viral pathogens which have undergone mutations, providing new insights and addressing research on unresolved issues. Porcine virus evolution, mutation and recombination, pathogenicity to pigs, escape from host immunity, and the efficacy of vaccines are just selection of topics relevant to research in the field, which can be contributed to this Special Issue. All researchers working in the field are cordially invited to contribute original research papers or propose reviews to this Special Issue of Viruses.

Prof. Dr. Kegong Tian
Prof. Dr. Xiangdong Li
Guest Editors

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Keywords

  • porcine viral diseases
  • epidemiology
  • pathogenesis
  • recombination
  • immune responses

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Published Papers (1 paper)

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Research

18 pages, 3490 KiB  
Article
Cinnamaldehyde Inhibits the Replication of Porcine Reproductive and Respiratory Syndrome Virus Type 2 In Vitro
by Junzhu Song, Jingyu Zhang, Jian Chen, Songbiao Chen, Zuhua Yu, Lei He, Ke Ding and Ying Wei
Viruses 2025, 17(4), 506; https://doi.org/10.3390/v17040506 - 31 Mar 2025
Viewed by 196
Abstract
Globally, the swine industry suffers significant economic losses due to the presence of porcine reproductive and respiratory syndrome virus (PRRSV). Unfortunately, existing vaccines fail to offer adequate protection against the various strains of PRRSV, and there are currently no specific treatments available for [...] Read more.
Globally, the swine industry suffers significant economic losses due to the presence of porcine reproductive and respiratory syndrome virus (PRRSV). Unfortunately, existing vaccines fail to offer adequate protection against the various strains of PRRSV, and there are currently no specific treatments available for this virus. In this study, we screened four natural products and identified cinnamaldehyde (CA) as an effective inhibitor of PRRSV infection in Marc-145 cells. CA could achieve an inhibition rate of up to 93% on PRRSV N protein at 160 μM. Mechanistically, CA exerted anti-PRRSV ability in different treatment modes. CA could directly interact with PRRSV particles. Cinnamaldehyde blocks the binding, entry, replication, and release of PRRSV. Furthermore, a significant reduction in dsRNA levels was observed in the CA-treated groups compared to the control groups. In conclusion, our research demonstrated that CA could inhibit essential stages of the PRRSV lifecycle: binding, entry, replication, and release. CA could directly interact with PRRSV. Additionally, CA disrupted the expression of dsRNA during viral replication, thereby suppressing in vitro PRRSV replication in Marc-145 cells. This study provides crucial perspectives on the potential application of CA for the prevention and treatment of PRRS. Full article
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