Dengue, Zika and Yellow Fever Virus Replication

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Invertebrate Viruses".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 857

Special Issue Editor


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Guest Editor
Centro de Investigacion y de Estudios Avanzadosdisabled, Mexico City, Mexico
Interests: flaviviridae; dengue; zika; yellow fever virus; viral multiplication

Special Issue Information

Dear Colleagues,

Members of the Flaviviridae family, including Dengue virus (DENV), Zika virus (ZIKV), and Yellow Fever virus (YFV), are mosquito-borne viruses that have caused significant burdens on public health in tropic and subtropic regions of the world. Although numerous antiviral compounds and inhibitory factors have been identified thus far, there are currently no specific treatment strategies or commercially available antiviral products for combating these flaviviral infections. In terms of virus replication, we understand that these mosquito-borne viruses have a cytoplasmic replication cycle; however, several lines of evidences suggest that nucleus and several other organelles play important roles during viral replication. Therefore, further research studies elucidating their replicative cycle and replication complexes formation are necessary for the development of antivirals targeting these flaviviruses. In this Special Issue, we will focus on general topics and new insights into mosquito-borne virus replication. There are no limitations on the types of contributions; original articles, brief communications, case reports, and reviews are welcome. The scope includes, but is not limited to, virus replication, virus entry, genome replication, host cell factors, replication structures, and infection models.

Prof. Dr. Rosa M. Del Angel
Guest Editor

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Keywords

  • flavivirus
  • dengue, Zika
  • yellow fever
  • virus replication
  • virus entry
  • genome replication
  • host cell factors
  • replication structures

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Published Papers (1 paper)

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Review

21 pages, 1963 KB  
Review
Lipids, Tetraspanins, and Exosomes: Cell Factors in Orthoflavivirus Replication and Propagation
by Magda L. Benitez-Vega, Carlos D. Cordero-Rivera, Jose De Jesus Bravo-Silva, Ricardo Jimenez-Camacho, Carlos Noe Farfan-Morales, Jonathan Hernández-Castillo, Marcos Pérez-García and Rosa M. del Ángel
Viruses 2025, 17(10), 1321; https://doi.org/10.3390/v17101321 - 29 Sep 2025
Viewed by 320
Abstract
The cellular membrane is a dynamic structure composed of lipids and proteins organized into specialized domains that facilitate interactions between extracellular molecules and the intracellular environment. Tetraspanins are a family of transmembrane proteins involved in diverse cellular processes, including membrane stabilization and fusion, [...] Read more.
The cellular membrane is a dynamic structure composed of lipids and proteins organized into specialized domains that facilitate interactions between extracellular molecules and the intracellular environment. Tetraspanins are a family of transmembrane proteins involved in diverse cellular processes, including membrane stabilization and fusion, endocytosis, extracellular vesicle formation, and the organization of proteins and lipids at specific membrane sites known as Tetraspanin-Enriched Microdomains (TEMs). These lipid–protein interactions play a critical role in the replicative cycle of Orthoflavivirus, including dengue, Zika, and West Nile, by facilitating viral entry, replication, assembly, and egress. In addition, tetraspanins also regulate the biogenesis and function of extracellular vesicles, contributing to viral dissemination, persistent infection, and immune evasion. This review summarizes the current knowledge on the structural and functional aspects of tetraspanins, their interplay with lipids, and their emerging roles in the Orthoflavivirus replicative cycle. We also discuss how these insights may inform the development of antiviral strategies targeting membrane organization and virus–host interactions. Full article
(This article belongs to the Special Issue Dengue, Zika and Yellow Fever Virus Replication)
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