HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0

Dear Colleagues,

The Special Issue "HIV-1 infection and immunometabolism: relevance to HIV pathogenesis and persistence" and "HIV-1 infection and immunometabolism: relevance to HIV pathogenesis and persistence 2.0" that was launched last two years, collected some interesting manuscripts regarding this topic. It is a great pleasure for me to introduce a third volume of this Special Issue that continues to be dedicated to the interplay between immunometabolism, HIV-1 pathogenesis and viral persistence. There is now an increasing body of evidence that dysfunctional immunometabolism represents a pivotal element to the biased immunity against HIV-1 infection, that leads to viral dissemination and establishment of virus reservoir. HIV-1 infection causes upregulated glycidic and lipidic metabolism and elevated oxidative stress in immune cells. How HIV-1 infection reprograms immunometabolism and the role of these metabolic alterations in the development and maintenance of HIV-1 latency have not been fully elucidated. The immunometabolic defects during HIV-1 infection, even under ART, may have a role also in non-AIDS defining cancers and neurocognitive diseases, representing a potential link between HIV-associated stimuli and age-related comorbidities, such as cardiovascular, bone and renal diseases, and frailty in HIV-positive individuals. Investigation of these topics will be important to more completely understand the role of immunometabolism in HIV-1 pathogenesis, and to have a clearer insight into how these processes interplay and affect HIV persistence.

This Special Issue will collect research or review articles addressing recent advances in the field of this topic. Also, novel approaches and technical advances, allowing for more precise measurements of metabolic activities in immune cells during HIV-1 infection, may be interesting in order to develop metabolic targeted therapies aiming at decreasing inflammation and HIV reservoir size in ART-treated HIV-infected people.

Dr. Sonia Moretti
Guest Editor

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