Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 270

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Guest Editor
Department of Pharmacy, Division of Pharmaceutical Chemistry, Panepistimiopolis Zografou-GR, 15771 Athens, Greece
Interests: medicinal chemistry; antiviral agents; anticancer agents; trypanocidal agents; anti-HBV drugs; anti-HCV drugs; anti-influenza A agents; anti-flavivirus agents
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Special Issue Information

Dear Colleagues,

Since the beginning of human civilization, viral infections have been part of human life and still represent one of the heaviest burdens for humans and society, with a huge devastating socioeconomic impact. The global burden of viral hepatitis remains substantial despite advances in antiviral therapy and effective vaccines. Mortality related to hepatitis B virus and hepatitis C virus infections is among the top four global infectious diseases, together with human immunodeficiency virus infection, malaria, and tuberculosis. According to the World Health Organization (WHO), for viral-infection-related diseases such as hepatitis B, the achievement of a suitable treatment still has a long way to go. On the other hand, the flaviviruses, Dengue (DENV), Yellow fever (YFV), Zika (ZIKV) and West Nile (WNV) are high-priority targets for drug discovery as they are re-emerging global pathogens with no clinically approved specific therapy (according to the WHO). WNV and YFV are among the most dangerous flaviviruses, having mortality rates up to 30%. Moreover, the emergence of drug resistance that threatens the efficacy of successful therapies used today against HCV makes the discovery and development of antiviral agents an unmet global need. Urged by this global crisis, the field has been involved in an unprecedented endeavour to enhance established antiviral strategies and develop novel and innovative approaches for new classes of antiviral agents targeting different and critical for the virus life cycle pathways, including viral and host factors and new antiviral modalities.

In this Special Issue entitled: “Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition”, we are inviting the submission of original research articles, letters, and/or reviews from academia, research institutes, not-for-profit organizations, or industries working over the identification, synthesis, and evaluation of direct-acting anti-HCV, anti-HBV, and anti-flavivirus agents or host-targeting agents which inhibit viral replication or pathogenesis (HCV, HBV, and flaviviruses). Furthermore, papers on mechanistic studies of new small organic molecules, metal complexes, and natural products, as well as studies on drug resistance, in silico designs of anti-HCV, anti-HBV, and anti-Flavivirus agents, or HCV, HBV, and flavivirus target validation studies are also welcome for submissions.

Dr. Grigoris Zoidis
Guest Editor

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Keywords

  • medicinal chemistry of anti-HCV, anti-HBV and anti-flavivirus agents
  • synthesis
  • structure activity relationships (SAR)
  • antiviral drug discovery
  • HBV
  • HCV
  • Dengue (DENV)
  • Yellow Fever (YFV)
  • West Nile (WNV)
  • Zika (ZIKV)
  • mechanism of action
  • drug targets
  • in silico studies

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Published Papers (1 paper)

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Research

14 pages, 997 KiB  
Article
Evaluation of Treatment Response in Chronic Hepatitis C Patients Receiving Sofosbuvir/Velpatasvir/Voxilaprevir: A Multicenter Real-World Experience from Türkiye
by Umut Devrim Binay, Faruk Karakeçili, Bilgehan Aygen, Ayşin Kılınç Toker, İlhami Çelik, Neşe Demirtürk, Tuğçe Şimşek Bozok, Leyla Dursun, Fethiye Akgül, Güle Çınar, Özgür Günal, Ali Asan, Eyüp Arslan, Fatma Yılmaz Karadağ, Orçun Barkay, İrem Akdemir, Funda Şimşek, Emine Türkoğlu Yılmaz, Zeynep Ravza Eğilmez, Süda Tekin and The Viral Hepatitis Study Group of the Turkish Society of Clinical Microbiology and Infectious Diseases (KLİMİK)add Show full author list remove Hide full author list
Viruses 2025, 17(7), 931; https://doi.org/10.3390/v17070931 - 30 Jun 2025
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Abstract
The combination of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) is recommended as a salvage therapy for treatment-experienced chronic hepatitis C (CHC) patients. However, it is used in our country for treatment-naïve and treatment-experienced patients. This study aims to present real-world data from Türkiye on CHC patients treated [...] Read more.
The combination of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) is recommended as a salvage therapy for treatment-experienced chronic hepatitis C (CHC) patients. However, it is used in our country for treatment-naïve and treatment-experienced patients. This study aims to present real-world data from Türkiye on CHC patients treated with SOF/VEL/VOX. The present study was conducted by the Viral Hepatitis Study Group of the Turkish Society of Clinical Microbiology and Infectious Diseases (KLİMİK). It was a multicenter, retrospective, observational study. The data were collected from patients receiving SOF/VEL/VOX therapy at 12 medical centers in Türkiye between 1 June 2022 and 31 December 2024. The patients had received the treatment for 8 to 12 weeks. Of the 139 patients enrolled, 63.3% (n = 88) were male, with a mean age of 54.4 years. Most patients were non-cirrhotic (94.2%, n = 131) and treatment-naïve (92%, n = 128); 49.6% (n = 69) were infected with genotype 1b. Early virologic response (EVR) could be assessed in 126 patients, with an EVR rate of 82.5% (n = 104). End-of-treatment data were available for 113 patients, all achieving an end-of-treatment response. Among the 80 patients for whom week-12 post-treatment data were available, 97.5% sustained virologic response at week 12 (SVR12). Significant improvements were observed in AST, ALT, and platelet levels, along with reductions in APRI and FIB-4 scores (p = 0.001).” No serious adverse events leading to treatment discontinuation were reported. Mild adverse events included pruritus (2.1%, n = 3), fatigue (2.1%, n = 3), and nausea (1.4%, n = 2). The SOF/VEL/VOX combination is a highly effective and well-tolerated treatment option in treatment-naïve CHC patients, achieving an SVR12 rate of 97.5%. Full article
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