Tick-Borne Viruses 2026

Dear Colleagues,

Tick-borne viruses (TBVs) represent a significant and expanding public health threat, with increasing incidence and geographic range driven by complex ecological, environmental, and anthropogenic factors. These viruses, transmitted by hard and soft ticks, encompass diverse taxa, including flaviviruses, orthonairoviruses, and phenuiviruses, many of which cause severe and sometimes fatal disease in humans and domesticated animals. The dynamics of TBV transmission are intimately linked to tick ecology, host availability, and climatic variables, all of which are undergoing rapid change. The mechanisms of tick-borne transmission, including tick saliva-mediated host interactions, exosomes, and antiviral mechanisms, challenge our understanding of how TBVs survive. At the same time, advances in surveillance techniques, high-throughput processing, and data analysis are revealing novel viruses and shedding light on the evolutionary relationships and zoonotic potential of these agents.

This Special Issue brings together original research articles and reviews that span the molecular biology, transmission, vector–host interactions, ecology, and emerging control strategies for tick-borne viruses. Our aim is to provide a comprehensive update on the current state of the field and to highlight critical knowledge gaps that warrant future investigation.

Prof. Dr. Pat Nuttall
Guest Editor

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